CAS 5786-21-0
:Clozapine
Description:
Clozapine is an atypical antipsychotic medication primarily used to treat schizophrenia, particularly in patients who are resistant to other treatments. It is known for its unique mechanism of action, which involves antagonism of various neurotransmitter receptors, including dopamine D4 and serotonin 5-HT2A receptors, contributing to its efficacy in alleviating psychotic symptoms. Clozapine is characterized by its relatively low propensity to cause extrapyramidal side effects compared to typical antipsychotics, making it a valuable option for treatment-resistant cases. However, it is associated with a risk of agranulocytosis, a potentially severe decrease in white blood cell count, necessitating regular blood monitoring. The substance is typically administered orally and has a complex pharmacokinetic profile, with a long half-life and extensive metabolism primarily in the liver. Clozapine's chemical structure includes a dibenzodiazepine core, which is integral to its pharmacological properties. Overall, while effective, its use requires careful management due to the associated risks and side effects.
Formula:C18H19ClN4
InChI:InChI=1/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChI key:InChIKey=QZUDBNBUXVUHMW-UHFFFAOYSA-N
SMILES:CN1CCN(C=2C=3C(NC=4C(N2)=CC(Cl)=CC4)=CC=CC3)CC1
Synonyms:- 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
- 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
- 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
- Apo-Clozapine
- Asaleptin
- Azaleptin
- Azaleptine
- Brn 0764984
- Ccris 9171
- Clorazil
- Cloril
- Clozapex
- Clozapin
- Clozapina
- Clozapina [INN-Spanish]
- Clozapinum
- Clozapinum [INN-Latin]
- Clozaril
- Fazaclo
- Fazaclo ODT
- Hf-1854
- Hsdb 6478
- Iprox
- Klozapol
- Leponex
- Lx 100-129
- Sizopin
- Unii-J60Ar2Ikic
- W-801
- Clozapine
- e)(1,4)diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(
- CLOZAPINE ATYPICAL NEUROLEPTIC
- LIPONEX
- Lepotex
- COLZARIL
- 8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(e)(1,4)diazepine
- See more synonyms
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Clozapine
CAS:Formula:C18H19ClN4Purity:>98.0%(GC)(T)Color and Shape:Light yellow to Amber to Dark green powder to crystalMolecular weight:326.83Clozapine, 97%
CAS:Potent, selective muscarinic antagonist
Formula:C18H19Cl4Purity:97%Molecular weight:326.83Clozapine
CAS:ClozapineFormula:C18H19ClN4Purity:99.9%Color and Shape:Off-WhiteMolecular weight:326.12982CLOZAPINE FOR PEAK IDENTIFICATION CRS
CAS:CLOZAPINE FOR PEAK IDENTIFICATION CRSFormula:C18H19ClN4Molecular weight:326.8233Clozapine
CAS:Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structureFormula:C18H19ClN4Color and Shape:Yellow PowderMolecular weight:326.12982Clozapine Resolution Mixture
CAS:Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structureColor and Shape:Yellow Crystalline PowderMolecular weight:203.09061Clozapine
CAS:Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent.Formula:C18H19ClN4Purity:99.91% - 99.93%Color and Shape:Yellow Crystals From Acetone-Petroleum Ether SolidMolecular weight:326.82Ref: TM-T0455
1g425.00€10mg34.00€25mg49.00€50mg66.00€100mg90.00€200mg161.00€500mg286.00€1mL*10mM (DMSO)44.00€Clozapine
CAS:Formula:C18H19Cl4Purity:≤ 0.3%Color and Shape:Yellow crystalline powderMolecular weight:326.83Clozapine-d4 (4-methylpiperazinyl-2,2,6,6-d4)
CAS:Purity:99 atom % DColor and Shape:Yellow SolidMolecular weight:330.85
