CAS 57982-77-1

Buserelin

Description:

Buserelin is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH), primarily used in medical applications related to hormone regulation. It functions as a potent agonist of GnRH receptors, leading to the stimulation of the pituitary gland and subsequent release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This action can be utilized in various therapeutic contexts, including the treatment of hormone-sensitive cancers, such as prostate cancer, and in assisted reproductive technologies. Buserelin is characterized by its ability to downregulate GnRH receptors with continuous administration, resulting in decreased levels of sex hormones. The substance is typically administered via injection and has a relatively short half-life, necessitating careful dosing regimens. Its chemical structure includes a specific sequence of amino acids that confer its biological activity, and it is classified as a peptide hormone. As with any medication, potential side effects may include hormonal imbalances and reactions at the injection site, highlighting the importance of medical supervision during its use.

Formula: C₆₀H₈₆N₁₆O₁₃

InChI: InChI=1/C60H86N16O13/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65)/t40-,41-,42-,43-,44-,45-,46-,47+,48-/m0/s1

Synonyms:

• 5-oxoprolylhistidyltryptophylseryltyrosyl-O-tert-butylserylleucyl-N~5~-(diaminomethylidene)ornithyl-N-ethylprolinamide
• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-N~5~-(diaminomethylidene)-L-ornithyl-N-ethyl-L-prolinamide
• [D-Ser(tert-butyl)6,des-Gly-NH210]-LH-RH ethylamide
• [D-Ser6(t-Bu),de-Gly10-NH2]-LH-RH ethylamide
• 1-9-(D-Ser(t-butyl))6-LH-releasing hormone ethylamide
• 1-9-Luteinizing hormone-releasing factor (swine), 6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-
• Buserelina
• Busereline
• Etilamide
• Hoe 766
• Hoe 766A
• Ici 123215
• Luteinizing hormone-releasing factor (pig), 6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-
• Receptal

(Des-Gly¹⁰,D-Ser(tBu)⁶,Pro-NHEt⁹)-LHRH

CAS: 57982-77-1

Buserelin is a longer acting synthetic peptide analog of the naturally occurring gonadotropin-releasing hormone (GnRH/LHRH). Substitution of glycine in position 6 by D-serine and that of glycinamide in position 10 by ethylamide, leads to a nonapeptide with a significantly enhanced LHRH effect. The effects of buserelin on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) release are approximately 20 to 170 times higher than those of natural LHRH. CAS Number (buserelin acetate): 68630-75-1.

Formula: C₆₀H₈₆N₁₆O₁₃

Purity: 98.0%

Color and Shape: White

Molecular weight: 1239.44

Ref: 01-4028150

Buserelin-d7 Tritrifluoroacetate

CAS: 57982-77-1

Formula: C₆₀H₇₉D₇N₁₆O₁₃·3C₂HF₃O₂

Molecular weight: 1246.49 3*114.02

Ref: 4Z-PB-102

Buserelin

CAS: 57982-77-1

Formula: C₆₀H₈₆N₁₆O₁₃

Purity: ≥ 97.0%

Color and Shape: White powder

Molecular weight: 1239.42

Ref: 7W-GP3966

Buserelin Ditrifluoroacetate

CAS: 57982-77-1

Formula: C₆₀H₈₆N₁₆O₁₃·2C₂HF₃O₂

Color and Shape: Off-White Solid

Molecular weight: 1239.45 2*114.02

Ref: 4Z-PB-101

Buserelin Acetate

CAS: 57982-77-1

Formula: C₆₀H₈₆N₁₆O₁₃

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 1239.43

Ref: BP-BPPG012

Buserelin

CAS: 57982-77-1

Buserelin

Color and Shape: White Lyophilised Powder

Molecular weight: 1,239.42g/mol

Ref: 54-BITH3005

(Des-Gly10,D-Ser(tBu)6,Pro-NHEt 9)-LHRH acetate salt

CAS: 57982-77-1

This drug is used for the treatment of endometriosis. It belongs to the class of drugs called GnRH analogues and acts by binding to receptors in the pituitary gland that control hormone production. The receptor is then activated, which leads to a decrease in the production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This results in a reduction in estrogen levels, which decreases uterine growth and thickening. The drug is used for short periods of time, usually 3-6 months, before taking a break for 1-2 months.
Estradiol benzoate is an estrogen medication that can be taken orally or via injection. It has been shown to have more beneficial effects on endometriosis than estradiol because it can improve symptoms such as pain and heavy menstrual bleeding. Estradiol benzoate may also be effective at treating autoimmune diseases because it has anti-inflammatory properties.
The mechanism of

Formula: C₆₀H₈₆N₁₆O₁₃

Purity: Min. 95%

Molecular weight: 1,239.42 g/mol

Ref: 3D-FD109219