CAS 58-05-9

Leucovorin

Description:

Leucovorin, also known as folinic acid, is a reduced form of folic acid that plays a crucial role in various biochemical processes, particularly in the synthesis of nucleic acids and amino acids. It is commonly used in medical settings as a rescue agent following methotrexate therapy, as it can help mitigate the drug's toxic effects on healthy cells by providing a source of active folate. Leucovorin is a white to off-white crystalline powder that is soluble in water, making it suitable for intravenous or oral administration. Its chemical structure includes a pteridine ring, a para-aminobenzoic acid moiety, and a glutamic acid residue, which contribute to its biological activity. Leucovorin is also utilized in combination with fluorouracil to enhance its efficacy in treating certain cancers. Due to its role in cellular metabolism, it is essential for proper DNA synthesis and repair, making it vital in both therapeutic and physiological contexts.

Formula: C₂₀H₂₃N₇O₇

InChI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1

InChI key: InChIKey=VVIAGPKUTFNRDU-ABLWVSNPSA-N

SMILES: C(=O)N1C2=C(NCC1CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)NC(N)=NC2=O

Synonyms:

• (6R,S)-5-Formyltetrahydrofolate
• 10-Formyl-7,8-dihydrofolic acid
• 5-Formyl-5,6,7,8-tetrahydrofolic acid
• 5-Formyltetrahydrofolic Acid
• 5-Formyltetrahydrofolsaure
• 5-Formyltetrahydropteroylglutamic acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Acide 5-Formyltetrahydrofolique
• Acido 5-Formiltetrahidrofolico
• CF
• Folinic acid
• Folinic acid-SF
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, L-
• Kunyrin
• L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Leucal
• Leucoverin
• Leucovorin
• Levoleucovorin
• N-[4-[[(2-Amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N5-Formyl-5,6,7,8-tetrahydrofolic acid
• N5-Formyltetrahydrofolic acid
• N⁵-Formyl-5,6,7,8-tetrahydrofolic acid
• N⁵-Formyl-THF
• N⁵-Formyltetrahydrofolic acid
• Welcovorin
• l-Leucovorin
• N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
• N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
• 5-formyltetrahydrofolate
• L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid
• N-[4-[[(2-Amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
• N5-formyl-5,6,7,8-tetrahydrofolate
• N5-formyl-tetrahydrofolate

Calcium Folinate

CAS: 1492-18-8, 2060570-47-8, 58-05-9, 6035-45-6

Formula: C₂₀H₂₁CaN₇O₇

Purity: >98.0%(T)(HPLC)

Color and Shape: Light orange to Yellow to Green powder to crystaline

Molecular weight: 511.51

Ref: 3B-C2235

(2S)-2-[[4-[(2-Amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

CAS: 58-05-9

Formula: C₂₀H₂₃N₇O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 473.4393

Ref: IN-DA003A0Z

Folinic acid

CAS: 58-05-9

Folinic acid

Purity: ≥98%

Molecular weight: 473.44g/mol

Ref: 54-BUP11034

Folinic Acid

CAS: 58-05-9

Folinic Acid

Purity: 98%

Molecular weight: 473.44g/mol

Ref: 54-OR1027762

Folinic Acid

CAS: 58-05-9

Applications Folinic Acid is used in combination with 5-fluorouracil in the treatment of colorectal cancers. It also functions as a useful antidotal therapy medication for decreasing the toxic effect of methotrexate overdosing.
References He, J., et al.: Cancer Sci., 111, 253 (2020); Labriet, A., et al.: Pharmacogenomics, 20, 1179 (2019); Pannu, A. K.: Curr. Drug Metab., 20, 714 (2019)

Formula: C₂₀H₂₃N₇O₇

Color and Shape: Neat

Molecular weight: 473.45

Ref: TR-F680340

Folinic acid

CAS: 58-05-9

Folinic acid (Leucovorin) is a biofolic acid that can be used in the treatment of methotrexate, often in combination with Methotrexate (MTX) to reduce MTX-

Formula: C₂₀H₂₃N₇O₇

Purity: 99.76%

Color and Shape: Crystals From Water With 3 Mol Of Water Of Crystallization Solid

Molecular weight: 473.44

Ref: TM-T24403

Folinic acid

CAS: 58-05-9

Folinic acid is a vitamin-B9 that is used as a cofactor for enzymes involved in the synthesis of DNA and RNA. It is also used to diagnose various infectious diseases, with high values found in patients with cancer or autoimmune diseases. Folinic acid has been shown to have dose-dependent effects on mammalian cells, exhibiting toxicities at higher concentrations. Folinic acid can be used to repair damaged DNA by acting as a glycosidase that breaks down the glycosidic bond between the base and sugar.

Formula: C₂₀H₂₃N₇O₇

Purity: (%) Min. 97%

Color and Shape: White Powder

Molecular weight: 473.44 g/mol

Ref: 3D-FF156776