CAS 58-05-9
:Leucovorin
Description:
Leucovorin, also known as folinic acid, is a reduced form of folic acid that plays a crucial role in various biochemical processes, particularly in the synthesis of nucleic acids and amino acids. It is commonly used in medical settings as a rescue agent following methotrexate therapy, as it can help mitigate the drug's toxic effects on healthy cells by providing a source of active folate. Leucovorin is a white to off-white crystalline powder that is soluble in water, making it suitable for intravenous or oral administration. Its chemical structure includes a pteridine ring, a para-aminobenzoic acid moiety, and a glutamic acid residue, which contribute to its biological activity. Leucovorin is also utilized in combination with fluorouracil to enhance its efficacy in treating certain cancers. Due to its role in cellular metabolism, it is essential for proper DNA synthesis and repair, making it vital in both therapeutic and physiological contexts.
Formula:C20H23N7O7
InChI:InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1
InChI key:InChIKey=VVIAGPKUTFNRDU-ABLWVSNPSA-N
SMILES:C(=O)N1C2=C(NCC1CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)NC(N)=NC2=O
Synonyms:- (6R,S)-5-Formyltetrahydrofolate
- 10-Formyl-7,8-dihydrofolic acid
- 5-Formyl-5,6,7,8-tetrahydrofolic acid
- 5-Formyltetrahydrofolic Acid
- 5-Formyltetrahydrofolsaure
- 5-Formyltetrahydropteroylglutamic acid
- <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
- <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
- Acide 5-Formyltetrahydrofolique
- Acido 5-Formiltetrahidrofolico
- CF
- Folinic acid
- Folinic acid-SF
- Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-
- Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, L-
- Kunyrin
- L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
- Leucal
- Leucoverin
- Leucovorin
- Levoleucovorin
- N-[4-[[(2-Amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
- N5-Formyl-5,6,7,8-tetrahydrofolic acid
- N5-Formyltetrahydrofolic acid
- N<sup>5</sup>-Formyl-5,6,7,8-tetrahydrofolic acid
- N<sup>5</sup>-Formyl-THF
- N<sup>5</sup>-Formyltetrahydrofolic acid
- Welcovorin
- l-Leucovorin
- N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
- N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
- 5-formyltetrahydrofolate
- L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
- N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid
- N-[4-[[(2-Amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
- N5-formyl-5,6,7,8-tetrahydrofolate
- N5-formyl-tetrahydrofolate
- See more synonyms
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(2S)-2-[[4-[(2-Amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
CAS:Formula:C20H23N7O7Purity:98%Color and Shape:SolidMolecular weight:473.4393Folinic Acid
CAS:Applications Folinic Acid is used in combination with 5-fluorouracil in the treatment of colorectal cancers. It also functions as a useful antidotal therapy medication for decreasing the toxic effect of methotrexate overdosing.
References He, J., et al.: Cancer Sci., 111, 253 (2020); Labriet, A., et al.: Pharmacogenomics, 20, 1179 (2019); Pannu, A. K.: Curr. Drug Metab., 20, 714 (2019)Formula:C20H23N7O7Color and Shape:NeatMolecular weight:473.45Folinic acid
CAS:Folinic acid (Leucovorin) is a biofolic acid that can be used in the treatment of methotrexate, often in combination with Methotrexate (MTX) to reduce MTX-Formula:C20H23N7O7Purity:99.76%Color and Shape:SolidMolecular weight:473.4393Folinic acid
CAS:Folinic acid is a vitamin-B9 that is used as a cofactor for enzymes involved in the synthesis of DNA and RNA. It is also used to diagnose various infectious diseases, with high values found in patients with cancer or autoimmune diseases. Folinic acid has been shown to have dose-dependent effects on mammalian cells, exhibiting toxicities at higher concentrations. Folinic acid can be used to repair damaged DNA by acting as a glycosidase that breaks down the glycosidic bond between the base and sugar.Formula:C20H23N7O7Purity:(%) Min. 97%Color and Shape:White PowderMolecular weight:473.44 g/mol(2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid
CAS:Purity:>98%Molecular weight:473.4460144
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