CAS 58-28-6: Desipramine hydrochloride
Description:Desipramine hydrochloride is a tricyclic antidepressant primarily used in the treatment of major depressive disorder and certain anxiety disorders. It functions by inhibiting the reuptake of norepinephrine and, to a lesser extent, serotonin, thereby increasing the levels of these neurotransmitters in the synaptic cleft. This mechanism contributes to its antidepressant effects. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for oral administration in tablet form or as an injectable solution. Desipramine hydrochloride has a relatively long half-life, allowing for once-daily dosing in many cases. Common side effects may include dry mouth, constipation, urinary retention, and sedation, while more serious risks involve cardiovascular issues and potential for overdose. Due to its side effect profile, it is generally prescribed with caution, particularly in patients with pre-existing heart conditions. As with all medications, it is essential for patients to consult healthcare professionals for personalized advice and monitoring during treatment.
Formula:C18H22N2·ClH
InChI:InChI=1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H
InChI key:InChIKey=XAEWZDYWZHIUCT-UHFFFAOYSA-N
SMILES:Cl.C=1C=CC2=C(C1)N(C=3C=CC=CC3CC2)CCCNC
- Synonyms:
- 10,11-Dihydro-5-(3-(methylamino)propyl)-5H-dibenz(b,f)azepine hydrochloride
- 10,11-Dihydro-5-(3-(methylamino)propyl)-5H-dibenz(b,f)azepine monohydrochloride
- 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine hydrochloride (1:1)
- 5-[3-(Methylamino)propyl]-5H-dibenz[b,f]azepine hydrochloride
- 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(methylamino)propyl)-, hydrochloride
- 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(methylamino)propyl)-, monohydrochloride
- 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N-methyl-, monohydrochloride
- 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-, hydrochloride (1:1)
- DMI hydrochloride
- Demethylimipramine hydrochloride
- See more synonyms
- Desimipramine, hydrochloride
- Desipramine HCl
- Desipramine hydrochloride [USAN:JAN]
- Desipramine monohydrochloride
- Desmethylimipramine chloride
- Desmethylimipramine hydrochloride
- Desmethylimipramine monohydrochloride
- Despramine Hydrochloride
- Ex 4355
- G 35020
- GMI
- Imipraminedemethyl hydrochloride
- Jb 8181
- N-(gamma-Methylaminopropyl)iminodibenzyl hydrochloride
- N-(γ-Methylaminopropyl)iminodibenzyl hydrochloride
- Norpolake
- Norpramin
- Nortimil
- Nortrimil
- Nsc 114901
- Pertofran
- Pertofrane
- Pertofrin
- Petilil
- Petylyl
- Rmi 9,384A
- Unii-1Y58Do4My1
- Desipramine hydrochloride
