CAS 58-28-6
:Desipramine hydrochloride
Description:
Desipramine hydrochloride is a tricyclic antidepressant primarily used in the treatment of major depressive disorder and certain anxiety disorders. It functions by inhibiting the reuptake of norepinephrine and, to a lesser extent, serotonin, thereby increasing the levels of these neurotransmitters in the synaptic cleft. This mechanism contributes to its antidepressant effects. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for oral administration in tablet form or as an injectable solution. Desipramine hydrochloride has a relatively long half-life, allowing for once-daily dosing in many cases. Common side effects may include dry mouth, constipation, urinary retention, and sedation, while more serious risks involve cardiovascular issues and potential for overdose. Due to its side effect profile, it is generally prescribed with caution, particularly in patients with pre-existing heart conditions. As with all medications, it is essential for patients to consult healthcare professionals for personalized advice and monitoring during treatment.
Formula:C18H23ClN2
InChI:InChI=1/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H
InChI key:InChIKey=XAEWZDYWZHIUCT-UHFFFAOYSA-N
SMILES:C(CCNC)N1C=2C(CCC=3C1=CC=CC3)=CC=CC2.Cl
Synonyms:- 10,11-Dihydro-5-(3-(methylamino)propyl)-5H-dibenz(b,f)azepine hydrochloride
- 10,11-Dihydro-5-(3-(methylamino)propyl)-5H-dibenz(b,f)azepine monohydrochloride
- 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine hydrochloride (1:1)
- 5-[3-(Methylamino)propyl]-5H-dibenz[b,f]azepine hydrochloride
- 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(methylamino)propyl)-, hydrochloride
- 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(methylamino)propyl)-, monohydrochloride
- 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N-methyl-, monohydrochloride
- 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-, hydrochloride (1:1)
- DMI hydrochloride
- Demethylimipramine hydrochloride
- Desimipramine, hydrochloride
- Desipramine HCl
- Desipramine hydrochloride [USAN:JAN]
- Desipramine monohydrochloride
- Desmethylimipramine chloride
- Desmethylimipramine hydrochloride
- Desmethylimipramine monohydrochloride
- Despramine Hydrochloride
- Ex 4355
- G 35020
- GMI
- Imipraminedemethyl hydrochloride
- Jb 8181
- N-(gamma-Methylaminopropyl)iminodibenzyl hydrochloride
- N-(γ-Methylaminopropyl)iminodibenzyl hydrochloride
- Norpolake
- Norpramin
- Nortimil
- Nortrimil
- Nsc 114901
- Pertofran
- Pertofrane
- Pertofrin
- Petilil
- Petylyl
- Rmi 9,384A
- Unii-1Y58Do4My1
- Desipramine hydrochloride
- n-(gamma-methylaminopropyl)iminodibenzylhydrochloride
- demethylimipraminehydrochloride
- Desipramine solution hydrochloride
- f)azepine,10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(monohydrochlor
- 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methyl-propan-1-amine
- Desipramine Hydrochloride (125 mg)I0E2831.000mg/mg(dr)
- Desipramine hydrochloride solution
- desmethylimipraminehydrochloride
- dmihydrochloride
- 5H-Dibenzb,fazepine-5-propanamine, 10,11-dihydro-N-methyl-, monohydrochloride
- imipraminedemethylhydrochloride
- g35020
- ex4355
- 10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(b,f)azepinehydrochloride
- 3-(5,6-dihydrobenzo[b][1
- 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methyl-amine
- 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine hydrochloride
- 10,11-Dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine
- 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methyl-propan-1-amine hydrochloride
- jb8181
- 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine
- Desipramine Hydrochloride (125 mg)
- [3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]methylamine hydrochloride
- 10,11-DIHYDRO-N-METHYL-5-H-DIBENZ-[B,F]AZEPINE HYDROCHLORIDE
- f)azepine,10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(hydrochlorid
- DESIPRAMINEHYDROCHLORIDE,USP
- DESIPRAMINE HYDROCHLORIDE METHANOL*SOLUT ION
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Desipramine hydrochloride
CAS:Desipramine hydrochlorideFormula:C18H23ClN2Color and Shape:Off-WhiteMolecular weight:302.8416DESIPRAMINE HYDROCHLORIDE CRS
CAS:DESIPRAMINE HYDROCHLORIDE CRSFormula:C18H23ClN2Color and Shape:Added ModifiedMolecular weight:302.8416Desipramine Hydrochloride
CAS:Antidepressants, tranquilizers and other psychotherapeutic agents, nesoiFormula:C18H22N2·HClColor and Shape:White Off-White PowderMolecular weight:302.15498Desipramine Hydrochloride
CAS:Desipramine HydrochlorideFormula:C18H23ClN2Purity:>98%Color and Shape:SolidMolecular weight:302.84Desipramine hydrochloride
CAS:Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine.Formula:C18H23ClN2Purity:99.58% - 99.96%Color and Shape:Gray SolidMolecular weight:302.84Desipramine hydrochloride
CAS:Formula:C18H22N2·HClPurity:≥ 97.0%Color and Shape:White to off-white powderMolecular weight:302.84Desipramine hydrochloride
CAS:Desipramine hydrochlorideFormula:C18H23ClN2Purity:≥98%Color and Shape:SolidMolecular weight:302.842Desipramine HCl (N-Desmethyl Imipramine HCl, N-Desmethyl Clomipramine HCl EP Impurity B HCl, Norimipramine HCl)
CAS:Formula:C18H22N2·HClMolecular weight:266.39 36.46Desipramine Hydrochloride
CAS:Controlled ProductFormula:C18H22N2·ClHColor and Shape:NeatMolecular weight:302.84Desipramine Hydrochloride
CAS:Formula:C18H22N2·HClPurity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:302.85Desipramine hydrochloride (Standard)
CAS:Desipramine hydrochloride (Standard) is a reference standard for research and analysis in studies involving Desipramine hydrochloride. Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically.Formula:C18H23ClN2Color and Shape:SolidMolecular weight:302.84Desipramine Hydrochloride
CAS:Controlled ProductApplications Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.
References Checkley, S.A, et al.: Br. J. Psychiatry, 138. 248 (1981), Zhu, M.Y., et al.: J. Neurochem., 70, 1547 (1998), Okugawa, G., et al.: J. Neuroindocrinol., 11, 887 (1999), Torres, G.E., et al.: Nat. Rev. Neurosci., 4, 13 (2003),Formula:C18H22N2·ClHColor and Shape:NeatMolecular weight:302.84
