CAS 58-40-2

Promazine

Description:

Promazine is an antipsychotic medication belonging to the phenothiazine class, primarily used to manage psychotic disorders and severe anxiety. It exhibits sedative and antiemetic properties, making it effective in treating nausea and vomiting as well. The chemical formula for promazine is C17H20N2S, and it features a thiazine ring, which is characteristic of phenothiazines. Promazine acts primarily as a dopamine antagonist, blocking dopamine receptors in the brain, which helps alleviate symptoms of psychosis. It also has antihistaminic properties, contributing to its sedative effects. The substance is typically administered orally or via injection, and its pharmacokinetics involve metabolism in the liver, with excretion primarily through urine. Common side effects may include sedation, dry mouth, and potential extrapyramidal symptoms, although these are generally less pronounced compared to other antipsychotics. Due to its sedative effects, caution is advised when used in conjunction with other central nervous system depressants. Overall, promazine is a valuable medication in psychiatric treatment, though it requires careful monitoring for side effects and interactions.

Formula: C₁₇H₂₀N₂S

InChI: InChI=1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3

InChI key: InChIKey=ZGUGWUXLJSTTMA-UHFFFAOYSA-N

SMILES: C(CCN(C)C)N1C=2C(SC=3C1=CC=CC3)=CC=CC2

Synonyms:

• 10-[3-(Dimethylamino)propyl]phenothiazine
• 3276Rp
• A 145
• Ampazine
• Berophen
• Esparin
• N,N-Dimethyl-10H-phenothiazine-10-propanamine
• N-(3-Dimethylaminopropyl)phenothiazine
• Neo-Hibernex
• Nsc 31447
• Phenothiazine, 10-[3-(dimethylamino)propyl]-
• Prazin
• Prazine
• Promazin
• Promazina
• Promazine
• Protactyl
• Romtiazin
• Rp 3276
• Sinophenin
• Tomil
• Verophen
• Wy 1094

Promazine Dimer Hydrochloride

Controlled Product

CAS: 58-40-2

Stability Hygroscopic
Applications Promazine Dimer Hydrochloride is an impurity of Promazine(P756300). Promazine is an antipsychotic and a tranquilizer.
References Banci, L., et al.: Biochemistry, 38, 3205 (1999), Lawal, O., et al.: Food Chemi., 87, 205 (2004), Shleev, S., et al.: Bioorg. Chem., 35, 35 (2007),

Formula: C₃₁H₃₁N₃S₂·ClH

Color and Shape: Neat

Molecular weight: 546.19

Ref: TR-P756305

Promazine

CAS: 58-40-2

Formula: C₁₇H₂₀N₂S

Molecular weight: 284.42

Ref: ST-EA-CP-P136000

Promazine

Controlled Product

CAS: 58-40-2

Formula: C₁₇H₂₀N₂S

Color and Shape: Neat

Molecular weight: 284.419

Ref: TR-P756320