CAS 58-46-8

(±)-Tetrabenazine

Description:

(±)-Tetrabenazine is a chemical compound primarily used as a medication for the treatment of movement disorders, particularly in conditions like Huntington's disease and tardive dyskinesia. It is classified as a monoamine depleting agent, specifically targeting the depletion of neurotransmitters such as dopamine. The compound has a complex structure featuring a tetrabenazine core, which contributes to its pharmacological activity. It is known for its ability to reduce involuntary movements by modulating dopaminergic activity in the brain. The substance is typically administered in its hydrochloride salt form and is characterized by its relatively low solubility in water, which influences its bioavailability. Side effects may include sedation, depression, and gastrointestinal disturbances, necessitating careful monitoring during treatment. Due to its effects on neurotransmitter levels, (±)-Tetrabenazine is classified as a controlled substance in some jurisdictions, reflecting its potential for misuse and the need for regulated use in clinical settings.

Formula: C₁₉H₂₇NO₃

InChI: InChI=1/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/s2

InChI key: InChIKey=MKJIEFSOBYUXJB-VTLFJGNJNA-N

SMILES: O(C)C=1C=C2[C@]3(N(C[C@H](CC(C)C)C(=O)C3)CCC2=CC1OC)[H]

Synonyms:

• 2-Oxo-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine
• 2H-Benzo[A]Quinolizin-2-One, 1,3,4,6,7,11B-Hexahydro-9,10-Dimethoxy-3-(2-Methylpropyl)-, (3R,11Br)-Rel-
• 2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-
• 2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, cis-
• 2H-benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-
• 3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
• 9,10-Dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isochinolin-2-on
• 9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
• Nsc 169886
• Nsc 172187
• Ro 1-9569
• Rubigen
• Tetrabenazin
• Tetrabenazina
• Xenazine
• cis-2-Oxo-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine

Tetrabenazine

CAS: 58-46-8

Formula: C₁₉H₂₇NO₃

Purity: >99.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 317.43

Ref: 3B-T2839

Tetrabenazine ((3RS,11bRS)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one)

CAS: 58-46-8

Drugs primarily affecting the central nervous system, not elsewhere specified or included

Formula: C₁₉H₂₇NO₃

Color and Shape: White Crystalline Powder

Molecular weight: 317.19909

Ref: 45-1649801

Tetrabenazine

CAS: 58-46-8

Tetrabenazine

Formula: C₁₉H₂₇NO₃

Purity: 99%

Molecular weight: 317.42

Ref: 54-OR1028221

Tetrabenazine

CAS: 58-46-8

Tetrabenazine

Formula: C₁₉H₂₇NO₃

Purity: ≥98%

Molecular weight: 317.42

Ref: 54-BUP15812

Tetrabenazine

CAS: 58-46-8

Tetrabenazine (Ro 1-9569) is a drug formerly used as an antipsychotic and treatment of various movement disorders.

Formula: C₁₉H₂₇NO₃

Purity: 98% - 99.91%

Color and Shape: Solid

Molecular weight: 317.42

Ref: TM-T0719

TETRABENAZINE

CAS: 58-46-8

Formula: C₁₉H₂₇NO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 317.4226

Ref: IN-DA003UMF

Tetrabenazine

CAS: 58-46-8

Formula: C₁₉H₂₇NO₃

Color and Shape: White To Off-White Solid

Molecular weight: 317.43

Ref: 4Z-T-781

Tetrabenazine

CAS: 58-46-8

Formula: C₁₉H₂₇NO₃

Molecular weight: 317.42

Ref: 7W-GK0293

Tetrabenazine-d7

CAS: 58-46-8

Formula: C₁₉H₂₀D₇NO₃

Color and Shape: White To Off-White Solid

Molecular weight: 324.47

Ref: 4Z-T-782

Tetrabenazine

CAS: 58-46-8

Formula: C₁₉H₂₇NO₃

Color and Shape: Neat

Molecular weight: 317.42

Ref: 86-MM1633.01

Tetrabenazine

CAS: 58-46-8

Formula: C₁₉H₂₇NO₃

Molecular weight: 317.43

Ref: ST-EA-CP-T104000

Tetrabenazine - Bio-X ™

Controlled Product

CAS: 58-46-8

Tetrabenazine is a drug that has been used for the treatment of Parkinson's disease. It acts by inhibiting dopamine release and reducing the activity of nerve cells in the brain. Tetrabenazine Bio-X is used to treat dyskinesias, that are abnormal and involuntary muscle movements by inhibiting the monoamine transporter (VMAT2). Tetrabenazine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use."

Formula: C₁₉H₂₇NO₃

Purity: Min. 99 Area-%

Color and Shape: White Powder

Molecular weight: 317.42 g/mol

Ref: 3D-BT164463

Tetrabenazine

CAS: 58-46-8

Ref: BE-RMCT107000

3-ISOBUTYL-9,10-DIMETHOXY-3,4,6,7-TETRAHYDRO-1H-PYRIDO[2,1-A]ISOQUINOLIN-2(11BH)-ONE

CAS: 58-46-8

Formula: C₁₉H₂₇NO₃

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 317.429

Ref: 10-F301460

Tetrabenazine

Controlled Product

CAS: 58-46-8

Applications Dopamine depleting agent. An antidyskinetic; antipsychotic.
References Schwartz, et al.: Biochem. Pharmacol., 15, 645 (1966), Janovic, J., et al.: Ann. Neurol., 11, 41 (1982), Janovic, J., et al.: Neurology, 38, 391 (1988),

Formula: C₁₉H₂₇NO₃

Color and Shape: Neat

Molecular weight: 317.42

Ref: TR-T284000

Tetrabenazine

Controlled Product

CAS: 58-46-8

Tetrabenazine is a drug that has been used for the treatment of Parkinson's disease. It acts by inhibiting dopamine release and reducing the activity of nerve cells in the brain. Tetrabenazine Bio-X is used to treat dyskinesias, that are abnormal and involuntary muscle movements by inhibiting the monoamine transporter (VMAT2).

Formula: C₁₉H₂₇NO₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 317.42 g/mol

Ref: 3D-FT28060