CAS 58-54-8

Ethacrynic acid

Description:

Ethacrynic acid is a synthetic organic compound classified as a loop diuretic, primarily used in the treatment of edema associated with congestive heart failure, liver cirrhosis, and renal disease. It is characterized by its chemical formula C13H12ClO4S and a molecular weight of approximately 299.75 g/mol. Ethacrynic acid is a white to off-white crystalline powder that is soluble in water and organic solvents like ethanol and methanol. Its mechanism of action involves inhibiting the sodium-potassium-chloride co-transporter in the renal tubules, leading to increased excretion of sodium, chloride, and water. This diuretic effect helps reduce fluid overload in patients. Ethacrynic acid may also have potential side effects, including electrolyte imbalances, dehydration, and ototoxicity, particularly when used in high doses or in patients with pre-existing conditions. Due to its unique structure, it is distinct from other loop diuretics, such as furosemide, and is often used in patients who are allergic to sulfonamide derivatives.

Formula: C₁₃H₁₂Cl₂O₄

InChI: InChI=1/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)

InChI key: InChIKey=AVOLMBLBETYQHX-UHFFFAOYSA-N

SMILES: C(C(CC)=C)(=O)C1=C(Cl)C(Cl)=C(OCC(O)=O)C=C1

Synonyms:

• (2,3-Dichloro-4-(2-Methylene-1-Oxobutyl)Phenoxy)-Acetic Acid
• (4-(2-Methylenebutyryl)-2,3-Dichlorophenoxy)Acetic Acid
• 2,3-Dichloro-4-(2-Methylenebutyryl)Phenoxyacetic Acid
• 2,3-Dichloro-4-(2-ethyl-1-oxo-2-propenyl)-phenoxyacetic acid
• 2-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid
• 2-[2,3-Dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
• 4-(2-Methylenebutyryl)Phenoxyacetic Acid
• Acetic acid, 2-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]-
• Acetic acid, [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]-
• Acetic acid, [2,3-dichloro-4-(2-methylenebutyryl)phenoxy]-
• Acide Etacrynique
• Acido Etacrinico
• Crinuril
• Crinuryl
• Dethacrynic acid
• Edecril
• Edecrin
• Edecrina
• Endecril
• Etacrinic Acid
• Etacrynic acid
• Etacrynsaure
• Etakrinic Acid
• Ethacrynic
• Hidromedin
• Hydromedin
• Mingit
• Mk-595
• Nsc 624008
• Nsc 85791
• Otacril
• Redmax
• Reomax
• Taladren
• Uregit
• [2,3-Dichloro-4-(2-methylenebutyryl)phenoxy]acetic acid
• [[2,3-Dichloro-4-[2-(methylene)butanoyl]phenyl]oxy]acetic acid
• (2,3-dichloro-4-(2-methylenebutyryl)phenoxy)-aceticaci
• (4-(2-methylenebutyryl)-2,3-dichlorophenoxy)aceticacid
• (2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy)-aceticaci
• (2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy)aceticacid
• kyselina4-(2-(1-butenyl)karbonyl)-2,3-dichlorfenoxyoctova
• ETHACRYNIC ACID
• kyselinaethakrynova
• etakrinicacid
• [2,3-Dichloro-4-(2-methylene-1-oxobutyl)phe-noxy]aceticacid
• methylenebutyrylphenoxyaceticacid

Ethacrynic acid

CAS: 58-54-8

Diuretic that acts by inhibiting sodium-potassium-chloride cotransport

Formula: C₁₃H₁₂Cl₂O₄

Molecular weight: 303.14

Ref: 02-J63684

Etacrynic Acid

CAS: 58-54-8

Color and Shape: Neat

Ref: 61-FOR1207.00

ETACRYNIC ACID CRS

CAS: 58-54-8

ETACRYNIC ACID CRS

Formula: C₁₃H₁₂Cl₂O₄

Color and Shape: Powder

Molecular weight: 303.138

Ref: 41-E1800000

ETACRYNIC ACID FOR SYSTEM SUITABILITY CRS

CAS: 58-54-8

ETACRYNIC ACID FOR SYSTEM SUITABILITY CRS

Formula: C₁₃H₁₂Cl₂O₄

Color and Shape: Powder

Molecular weight: 303.138

Ref: 41-Y0001263

Ethacrynic Acid

CAS: 58-54-8

Carboxylic acids with additional oxygen function and th

Formula: C₁₃H₁₂Cl₂O₄

Color and Shape: White Off-White Powder

Molecular weight: 303.14

Ref: 45-1256004

Ethacrynic Acid

CAS: 58-54-8

Formula: C₁₃H₁₂Cl₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 303.14

Ref: 4Z-E-291

Etacrynic Acid

Controlled Product

CAS: 58-54-8

Formula: C₁₃H₁₂Cl₂O₄

Color and Shape: Neat

Molecular weight: 303.14

Ref: 86-MM1207.00

Ethacrynic acid

CAS: 58-54-8

Color and Shape: Neat

Ref: 04-CA13219300

Ethacrynic acid

CAS: 58-54-8

Ethacrynic acid (Edecrin) 是谷胱甘肽 S-转移酶抑制剂，也是NF-κB 信号传导途径的有效抑制剂，并且还调节白三烯的形成。它还可抑制 L 型电压依赖性和储存操作的钙通道，从而导致气道平滑肌细胞松弛。它是利尿剂，具有抗炎特性，可减轻类维生素 A 诱导的小鼠耳部水肿。

Formula: C₁₃H₁₂Cl₂O₄

Purity: 98.61% - 99.85%

Color and Shape: Crystals Physical Description White Solid (Ntp 1992)

Molecular weight: 303.14

Ref: TM-T4564

Ethacrynic Acid

Controlled Product

CAS: 58-54-8

Applications Ethacrynic Acid is a diuretic used to treat high blood pressure and swelling caused by congestive heart failure, liver failure and kidney failure.
References Beyer, et al.: J. Pharmacol. Exp. Ther., 147, 1 (1965); Kim., et al.: Am. J. Cardiol., 27, 407 (1971); Williamson, H.E., et al.: J. Clin. Pharmacol., 17, 663 (1977);

Formula: C₁₃H₁₂Cl₂O₄

Color and Shape: Neat

Molecular weight: 303.14

Ref: TR-E676000

Ethacrynic acid

Controlled Product

CAS: 58-54-8

Ethacrynic acid is a non-competitive, reversible inhibitor of the Na+/K+-ATPase. It has been shown to be effective against cancer tissues and infectious diseases such as malaria, tuberculosis, and leishmaniasis. Ethacrynic acid inhibits 2,4-dichlorobenzoic acid (2,4-DCBA)-induced tumor growth in mice by inducing apoptosis in human leukemia cells. Ethacrynic acid also inhibits mitochondrial membrane potential and cellular physiology by decreasing the activity of enzymes which are involved in energy metabolism.

Formula: C₁₃H₁₂Cl₂O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 303.14 g/mol

Ref: 3D-FE22848

ETHACRYNIC ACID

CAS: 58-54-8

Purity: 95%

Molecular weight: 303.1400146

Ref: 10-F822272

Ethacrynic acid

CAS: 58-54-8

Formula: C₁₃H₁₂Cl₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 303.1380

Ref: IN-DA0186KQ

Etacrynic acid

CAS: 58-54-8

Etacrynic acid

Formula: C₁₃H₁₂Cl₂O₄

Purity: 99.2%

Color and Shape: Off-White

Molecular weight: 302.01126

Ref: 47-143