CAS 58-73-1

Diphenhydramine

Description:

Diphenhydramine is an antihistamine commonly used to relieve symptoms of allergy, hay fever, and the common cold. It is classified as a first-generation H1 receptor antagonist, which means it blocks the action of histamine, a substance in the body that causes allergic symptoms. Chemically, diphenhydramine is characterized by its structure, which includes two phenyl rings connected by an ethylamine chain. This structure contributes to its ability to cross the blood-brain barrier, leading to sedative effects, which is why it is also used as a short-term treatment for insomnia. Diphenhydramine has a relatively low solubility in water but is soluble in organic solvents. Its pharmacological effects can include drowsiness, dry mouth, dizziness, and in some cases, paradoxical reactions such as excitability, especially in children. Due to its sedative properties, caution is advised when operating machinery or driving after consumption. Additionally, it may interact with other medications, so it is important to consult healthcare professionals before use.

Formula: C₁₇H₂₁NO

InChI: InChI=1/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3

InChI key: InChIKey=ZZVUWRFHKOJYTH-UHFFFAOYSA-N

SMILES: C(OCCN(C)C)(C1=CC=CC=C1)C2=CC=CC=C2

Synonyms:

• 2-(Benzhydryloxy)-N,N-dimethylethanamine
• 2-(Benzhydryloxy)-N,N-dimethylethylamine
• 2-(Diphenylmethoxy)-N,N-dimethylethanamine
• 2-(Diphenylmethoxy)-N,N-dimethylethylamine
• 2-Benzhydryloxyethyldimethylamine
• Benzhydramine
• DPH
• Difenhidramina
• Dimedrol base
• Diphenhydramin
• Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-
• Ethylamine, 2-(diphenylmethoxy)-N,N-dimethyl-
• Far 90X2
• N,N-Dimethyl-2-(diphenylmethoxy)ethylamine
• N-[2-(Diphenylmethoxy)ethyl]-N,N-dimethylamine
• Nsc 665800
• O-Benzhydryldimethylaminoethanol
• Probedryl
• Restamin
• α-(2-Dimethylaminoethoxy)diphenylmethane
• β-Dimethylaminoethanol diphenylmethyl ether
• β-Dimethylaminoethyl benzhydryl ether
• β-Dimethylaminoethylbenzhydrylether
• Diphenylhydramine
• Allergeval
• 2-(Diphenylmethoxy)-N,N-dimethylethanam-ine
• Allergical
• Aleryl
• Allergival
• Allergan B
• 2-(diphenylmethoxy)-n,n-dimethyl-ethanamin
• DIPHENHYDRAMINE BASE
• 2-(Benzohydryloxy)-N,N-dimethylethylamine
• AURORA KA-7664
• 2-(diphenylmethoxy)-n,n-dimethyl-ethylamin
• Alledryl
• DIPHENHYDRAMINE

Diphenhydramine Hydrochloride

CAS: 147-24-0, 58-73-1

Formula: C₁₇H₂₁NO·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White powder to crystal

Molecular weight: 291.82

Ref: 3B-D0423

Diphenhydramine

CAS: 147-24-0, 58-73-1

Formula: C₁₇H₂₁NO

Purity: >98.0%(GC)(T)

Color and Shape: Colorless to Yellow clear liquid

Molecular weight: 255.36

Ref: 3B-D4744

Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-

CAS: 58-73-1

Formula: C₁₇H₂₁NO

Purity: 98%

Color and Shape: Liquid

Molecular weight: 255.3547

Ref: IN-DA00IABH

Diphenhydramine

CAS: 58-73-1

Diphenhydramine

Purity: >98.0%

Molecular weight: 255.36g/mol

Ref: 54-OR1028917

Diphenhydramine

CAS: 58-73-1

Diphenhydramine

Purity: ≥98%

Molecular weight: 255.35g/mol

Ref: 54-BUP17662

Orphenadrine EP Impurity D (Diphenhydramine)

CAS: 58-73-1

Formula: C₁₇H₂₁NO

Color and Shape: Yellow Liquid

Molecular weight: 255.36

Ref: 4Z-O-0515

Diphenhydramine

CAS: 58-73-1

Formula: C₁₇H₂₁NO

Color and Shape: Neat

Molecular weight: 255.361

Ref: 04-C12880900

Diphenhydramine

CAS: 58-73-1

Diphenhydramine (Syntedril): first-gen antihistamine for allergies, antiemetic, antitussive, anticholinergic, sedative, treats drug-induced parkinsonism.

Formula: C₁₇H₂₁NO

Purity: 98.07%

Color and Shape: Solid

Molecular weight: 255.35

Ref: TM-T21419

Diphenhydramine

Controlled Product

CAS: 58-73-1

Applications Diphenhydramine can be used for improving dry skin with itching.
References Takeshima, H., et.al.: Jpn. Kokai Tokkyo Koho, 12, (2021);

Formula: C₁₇H₂₁NO

Color and Shape: Neat

Molecular weight: 255.361

Ref: TR-D487128

2-(Benzhydryloxy)-N,N-dimethylethanamine

CAS: 58-73-1

Formula: C₁₇H₂₁NO

Purity: 95%

Color and Shape: Liquid

Molecular weight: 255.361

Ref: 10-F240774

Diphenhydramine

Controlled Product

CAS: 58-73-1

Diphenhydramine is a drug that belongs to the class of antihistamines, and is used to treat allergic symptoms such as hay fever, urticaria, and other allergic reactions. It has been shown to inhibit the production of hydrogen fluoride in analytical methods for measuring this compound. Diphenhydramine is also known to have potential interactions with other drugs, including α1-adrenergic antagonists (i.e., h1-antagonists), cyclic peptides, and surfactants. In addition, it has been shown to bind to the α1 subunit of G protein receptors within the gastrointestinal tract in a reaction mechanism that is not yet fully understood. This binding inhibits the response of these receptors to certain stimuli from neurotransmitters and hormones, which can lead to bowel disease.

Formula: C₉H₁₈CINO

Purity: Min. 95%

Molecular weight: 295.16 g/mol

Ref: 3D-FD37055