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CAS 58-93-5

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Hydrochlorothiazide

Description:
Hydrochlorothiazide is a thiazide diuretic commonly used in the treatment of hypertension and edema associated with heart failure, liver cirrhosis, and renal disorders. Its chemical formula is C7H8ClN3O4S, and it features a sulfonamide group, which is integral to its mechanism of action. Hydrochlorothiazide works by inhibiting the sodium-chloride symporter in the distal convoluted tubule of the nephron, leading to increased excretion of sodium and water, thereby reducing blood volume and lowering blood pressure. The substance is typically administered orally and is known for its relatively rapid onset of action. Hydrochlorothiazide is characterized by its moderate solubility in water and is often formulated in combination with other antihypertensive agents to enhance therapeutic efficacy. Common side effects may include electrolyte imbalances, particularly hypokalemia, and it may also affect glucose metabolism. As with any medication, it is essential to use hydrochlorothiazide under medical supervision to monitor for potential adverse effects and interactions with other drugs.
Formula:C7H8ClN3O4S2
InChI:InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
InChI key:InChIKey=JZUFKLXOESDKRF-UHFFFAOYSA-N
SMILES:O=S1(=O)C=2C(=CC(Cl)=C(S(N)(=O)=O)C2)NCN1
Synonyms:
  • 3,4-Dihydrochlorothiazide
  • 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 6-Chloro-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • 6-Chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • 6-Chloro-7-sulfamoyl-3,4-dihydrobenzo-1,2,4-thiadiazine-1,1-dioxide
  • Acuretic
  • Apo-Hydro
  • Apresazide
  • Aquarius
  • Aquazide
  • See more synonyms
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