CAS 58-94-6

chlorothiazide

Description:

Chlorothiazide is a thiazide diuretic commonly used in the treatment of hypertension and edema associated with heart failure or renal disorders. Its chemical formula is C7H6ClN3O4S, and it features a sulfonamide group, which is characteristic of thiazide diuretics. Chlorothiazide works by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron, leading to increased excretion of sodium and water, thereby reducing blood volume and lowering blood pressure. The substance is typically administered orally and is known for its relatively rapid onset of action. Chlorothiazide may also have effects on electrolyte balance, particularly potassium, which can lead to hypokalemia if not monitored. It is important to consider potential side effects, including dizziness, gastrointestinal disturbances, and allergic reactions. As with any medication, its use should be guided by a healthcare professional, taking into account individual patient factors and potential drug interactions.

Formula: C₇H₆ClN₃O₄S₂

InChI: InChI=1/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H2,9,12,13)(H,10,11,14,15)

InChI key: InChIKey=JBMKAUGHUNFTOL-UHFFFAOYSA-N

SMILES: O=S1(=O)C=2C(=CC(Cl)=C(S(N)(=O)=O)C2)NC=N1

Synonyms:

• 2-Chloro-1,2,4-Benzothiadiazine-7-Sulphonamide 1,1-Dioxide
• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide
• 6-Chloro-1-Hydroxy-1Lambda~4~,2,4-Benzothiadiazine-7-Sulfonamide 1-Oxide
• 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
• 6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
• 6-Chloro-7-sulfamyl-1,2,4-benzothiadiazine 1,1-dioxide
• 6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• Alurene
• Chlorosal
• Chlorothiazid
• Chlorthiazide
• Chlorurit
• Chlotride
• Clorotiazida
• Clotride
• Diuresal
• Diuril
• Diuril Boluses
• Diurilix
• Diurite
• Diutrid
• Flumen
• Minzil
• Neo-Dema
• Nsc 25693
• Salisan
• Salunil
• Saluretil
• Saluric
• Thiazide
• Urinex
• Warduzide
• Yadalan
• Chlorothiazide
• Chlortiazid
• Chlrosal
• Aldoclor

Chlorothiazide

CAS: 58-94-6

Formula: C₇H₆ClN₃O₄S₂

Purity: >97.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 295.71

Ref: 3B-C2259

Chlorothiazide

CAS: 58-94-6

Color and Shape: Neat

Ref: 61-FOR0011.03

CHLOROTHIAZIDE CRS

CAS: 58-94-6

CHLOROTHIAZIDE CRS

Formula: C₇H₆ClN₃O₄S₂

Molecular weight: 295.7232

Ref: 41-C1700000

Chlorothiazide

CAS: 58-94-6

Chlorothiazide

Color and Shape: White. To. Off-White

Ref: 47-76

Chlorothiazide

CAS: 58-94-6

Sulfonamides used as drugs

Formula: C₇H₆ClN₃O₄S₂

Color and Shape: White Powder

Molecular weight: 294.94883

Ref: 45-1121005

Chlorothiazide (Hydrochlorothiazide EP Impurity A)

CAS: 58-94-6

Formula: C₇H₆ClN₃O₄S₂

Molecular weight: 295.71

Ref: 4Z-C-449001

Chlorothiazide

CAS: 58-94-6

Chlorothiazide (Diuril) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.

Formula: C₇H₆ClN₃O₄S₂

Purity: 98.46% - 98.91%

Color and Shape: Crystals Physical Description Crystals; White Powder (Ntp 1992)

Molecular weight: 295.72

Ref: TM-T0677

Chlorothiazide

CAS: 58-94-6

Formula: C₇H₆ClN₃O₄S₂

Purity: ≥ 97.0%

Color and Shape: White to off-white powder or crystals

Molecular weight: 295.72

Ref: 7W-GK7819

Chlorothiazide

Controlled Product

CAS: 58-94-6

Formula: C₇H₆ClN₃O₄S₂

Color and Shape: Neat

Molecular weight: 295.72

Ref: 86-MM0011.03

Chlorothiazide

CAS: 58-94-6

Formula: C₇H₆ClN₃O₄S₂

Color and Shape: Neat

Molecular weight: 295.72

Ref: 04-C11510700

Chlorothiazide 100 µg/mL in Acetonitrile

CAS: 58-94-6

Formula: C₇H₆ClN₃O₄S₂

Color and Shape: Single Solution

Molecular weight: 295.72

Ref: 04-A11510700AL-100

Chlorothiazide

Controlled Product

CAS: 58-94-6

Impurity Hydrochlorothiazide EP Impurity A
Applications Diuretic; antihypertensive. Hydrochlorothiazide EP Impurity A.
References Brittain, H.G., et al.: Anal. Profiles Drug Subs., 18, 33 (1989), Yoshida, F., et al.: J. Med. Chem., 43, 2575 (2000), Luan, F., et al.: Chem. Res. Toxicol., 18, 198 (2005), Si, H., et al.: Bioorg. Med. Chem., 14, 4834 (2006),

Formula: C₇H₆ClN₃O₄S₂

Color and Shape: White To Off-White

Molecular weight: 295.72

Ref: TR-C380000

Hydrochlorothiazide EP Impurity A

CAS: 58-94-6

Formula: C₇H₆ClN₃O₄S₂

Molecular weight: 295.71

Ref: ST-EA-CP-H3001

Chlorothiazide

Controlled Product

CAS: 58-94-6

Chlorothiazide is a diuretic that is a thiazide. It is used in combination preparations to treat high blood pressure (hypertension) and congestive heart failure. Chlorothiazide is also used to reduce the amount of fluid in the body (edema) and as an adjuvant therapy for kidney disease. This drug has been shown to be safe at therapeutic doses, although it may have some toxic effects on liver function. The toxicity studies on chlorothiazide have demonstrated no carcinogenic effects in either animals or humans, but there are reports of some skin cancer cases among people who have taken this drug for many years.

Formula: C₇H₆ClN₃O₄S₂

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 295.73 g/mol

Ref: 3D-FC20399

6-chloro-1,1-dioxo-2H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide

CAS: 58-94-6

Purity: 95%

Molecular weight: 295.7099915

Ref: 10-F814386

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide

CAS: 58-94-6

Formula: C₇H₆ClN₃O₄S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 295.7232

Ref: IN-DA00IABK