CAS 58-94-6
:chlorothiazide
Description:
Chlorothiazide is a thiazide diuretic commonly used in the treatment of hypertension and edema associated with heart failure or renal disorders. Its chemical formula is C7H6ClN3O4S, and it features a sulfonamide group, which is characteristic of thiazide diuretics. Chlorothiazide works by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron, leading to increased excretion of sodium and water, thereby reducing blood volume and lowering blood pressure. The substance is typically administered orally and is known for its relatively rapid onset of action. Chlorothiazide may also have effects on electrolyte balance, particularly potassium, which can lead to hypokalemia if not monitored. It is important to consider potential side effects, including dizziness, gastrointestinal disturbances, and allergic reactions. As with any medication, its use should be guided by a healthcare professional, taking into account individual patient factors and potential drug interactions.
Formula:C7H6ClN3O4S2
InChI:InChI=1/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H2,9,12,13)(H,10,11,14,15)
InChI key:InChIKey=JBMKAUGHUNFTOL-UHFFFAOYSA-N
SMILES:O=S1(=O)C=2C(=CC(Cl)=C(S(N)(=O)=O)C2)NC=N1
Synonyms:- 2-Chloro-1,2,4-Benzothiadiazine-7-Sulphonamide 1,1-Dioxide
- 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide
- 6-Chloro-1-Hydroxy-1Lambda~4~,2,4-Benzothiadiazine-7-Sulfonamide 1-Oxide
- 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
- 6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
- 6-Chloro-7-sulfamyl-1,2,4-benzothiadiazine 1,1-dioxide
- 6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
- Alurene
- Chlorosal
- Chlorothiazid
- Chlorthiazide
- Chlorurit
- Chlotride
- Clorotiazida
- Clotride
- Diuresal
- Diuril
- Diuril Boluses
- Diurilix
- Diurite
- Diutrid
- Flumen
- Minzil
- Neo-Dema
- Nsc 25693
- Salisan
- Salunil
- Saluretil
- Saluric
- Thiazide
- Urinex
- Warduzide
- Yadalan
- Chlorothiazide
- Chlortiazid
- Chlrosal
- Aldoclor
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Chlorothiazide
CAS:Formula:C7H6ClN3O4S2Purity:>97.0%(HPLC)(T)Color and Shape:White to Almost white powder to crystalMolecular weight:295.71Chlorothiazide
CAS:Sulfonamides used as drugsFormula:C7H6ClN3O4S2Color and Shape:White PowderMolecular weight:294.94883Chlorothiazide
CAS:Formula:C7H6ClN3O4S2Purity:≥ 97.0%Color and Shape:White to off-white powder or crystalsMolecular weight:295.72Chlorothiazide
CAS:Chlorothiazide (Diuril) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.Formula:C7H6ClN3O4S2Purity:98.46% - 98.91%Color and Shape:White SolidMolecular weight:295.72Chlorothiazide 100 µg/mL in Acetonitrile
CAS:Formula:C7H6ClN3O4S2Color and Shape:Single SolutionMolecular weight:295.72Chlorothiazide
CAS:Controlled ProductImpurity Hydrochlorothiazide EP Impurity A
Applications Diuretic; antihypertensive. Hydrochlorothiazide EP Impurity A.
References Brittain, H.G., et al.: Anal. Profiles Drug Subs., 18, 33 (1989), Yoshida, F., et al.: J. Med. Chem., 43, 2575 (2000), Luan, F., et al.: Chem. Res. Toxicol., 18, 198 (2005), Si, H., et al.: Bioorg. Med. Chem., 14, 4834 (2006),Formula:C7H6ClN3O4S2Color and Shape:NeatMolecular weight:295.72Chlorothiazide
CAS:Controlled ProductChlorothiazide is a diuretic that is a thiazide. It is used in combination preparations to treat high blood pressure (hypertension) and congestive heart failure. Chlorothiazide is also used to reduce the amount of fluid in the body (edema) and as an adjuvant therapy for kidney disease. This drug has been shown to be safe at therapeutic doses, although it may have some toxic effects on liver function. The toxicity studies on chlorothiazide have demonstrated no carcinogenic effects in either animals or humans, but there are reports of some skin cancer cases among people who have taken this drug for many years.Formula:C7H6ClN3O4S2Purity:Min. 95%Color and Shape:White/Off-White SolidMolecular weight:295.73 g/molChlorothiazide in Methanol
CAS:MethanolFormula:C7H6ClN3O4S2Color and Shape:SolidMolecular weight:295.76-chloro-1,1-dioxo-2H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide
CAS:Purity:>97.0%(HPLC)(T)Molecular weight:295.7099915
