CAS 58002-62-3

kainic acid monohydrate

Description:

Kainic acid monohydrate is a naturally occurring amino acid derivative, primarily known for its role as a neurotoxin and its use in neuroscience research. It is derived from the red alga *Digenea simplex* and is classified as a glutamate analog, which means it can interact with glutamate receptors in the brain. The substance is characterized by its crystalline structure and is typically found as a white to off-white powder. Kainic acid monohydrate is soluble in water and exhibits a relatively high melting point. Its chemical formula reflects the presence of a carboxylic acid group, contributing to its acidic properties. The compound is often utilized in experimental settings to induce excitotoxicity in neuronal studies, helping researchers understand various neurological conditions. Additionally, it has been investigated for its potential therapeutic applications, although its neurotoxic effects necessitate careful handling and usage. Overall, kainic acid monohydrate is significant in both biochemical research and pharmacological studies.

Formula: C₁₀H₁₇NO₅

InChI: InChI=1/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1

InChI key: FZNZRJRSYLQHLT-SLGZUKMRSA-N

SMILES: CC(=C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O.O

Synonyms:

• (-)-Kainic acid Monohydrat
• (3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-yl-L-proline hydrate (1:1)
• Kainic Acid 2-Carboxy-3-Carboxymethyl-4-Isopropenylpyrrolidine
• 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE
• Kainic acid monohydrate,2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine
• (2S,3S,4S)-3-(carboxyMethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid hydrate
• [2S-(2A,3BETA,4BETA)]-2-CAROXY-4-(1-METHYLETHENYL)-3-PYRROLIDINEACETIC ACID, MONOHYDRATE
• (?)-(α)-Kainic Acid hydrate
• (2S,3S,4S)-2-CARBOXY-4-ISOPROPENYL-3-PYRROLIDINEACETIC ACID
• KAINIC ACID MONOHYDRATE
• 3-Pyrrolidineaceticacid, 2-carboxy-4-(1-Methylethenyl)-, hydrate (1:1), (2S,3S,4S)-
• KAINIC ACID HYDRATE
• KAINIC ACID MONOHYDRATE, ISOLATED FROM D
• [2S-(2alpha,3beta,4beta)]-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid monohydrate
• kainic acid monohydrate from digenea simplex
• 2-CARBOXYL-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE MONOHYDRATE
• KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE USP/EP/BP
• (-)-KAINIC ACID, MONOHYDRATE
• ([2S-(2a,34]-2-Caroxy-4-(1-methylethenyl)-3-pyrrolidineacetic Acid

(-)-(α)-Kainic Acid (hydrate)

CAS: 58002-62-3

(-)-(α)-Kainic Acid (hydrate) is a potent excitotoxic agent that can induce seizures.

Formula: C₁₀H₁₇NO₅

Color and Shape: Solid

Molecular weight: 231.25

Ref: TM-T37557

Kainic acid monohydrate

CAS: 58002-62-3

Formula: C₁₀H₁₅NO₄·H₂O

Molecular weight: 231.25

Ref: 7W-GL0701

Kainic acid (hydrate)

CAS: 58002-62-3

Kainic acid (hydrate)

Purity: 98%

Molecular weight: 231.25g/mol

Ref: 54-OR1075833

Kainic acid monohydrate

CAS: 58002-62-3

Formula: C₁₀H₁₇NO₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 231.2457

Ref: IN-DA00352K

Kainic acid monohydrate

CAS: 58002-62-3

Agonist of kainate receptors, a subclass of ionotropic glutamate receptors with neuroexcitatory action. At high concentrations, it can induce seizures and act as neurotoxin, causing neuron death due to overstimulation.

Formula: C₁₀H₁₅NO₄·H₂O

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 231.25 g/mol

Ref: 3D-FK46986

Kainic acid hydrate

CAS: 58002-62-3

Purity: 98%

Molecular weight: 231.111

Ref: 10-F865954

(-)-Alpha-Kainic Acid Monohydrate

Controlled Product

CAS: 58002-62-3

Applications (-)-α-Kainic Acid Monohydrate is the monohydrated form of (-)-α-Kainic Acid (K135010); a naturally occurring neuroexcitatory chemical that is a selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.
References Wacker, D.A., et al.: Synlett, 503 (1997); Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)

Formula: C₁₀H₁₅NO₄·H₂O

Color and Shape: Neat

Molecular weight: 231.246

Ref: TR-K445000