CAS 585543-15-3

Losmapimod

Description:

Losmapimod is a small molecule inhibitor primarily known for its role as a selective inhibitor of p38 mitogen-activated protein kinase (MAPK). This compound has garnered attention in the field of pharmacology for its potential therapeutic applications, particularly in inflammatory diseases and conditions associated with chronic pain. Losmapimod exhibits a moderate to high degree of solubility in organic solvents, which is typical for many small molecule inhibitors. Its chemical structure features a pyridinyl moiety, contributing to its biological activity. The compound has been studied in various preclinical and clinical settings, demonstrating efficacy in modulating inflammatory responses. Additionally, Losmapimod's pharmacokinetic profile suggests it has a favorable absorption and distribution in biological systems, although its metabolism and excretion pathways are essential for understanding its overall safety and efficacy. As with many investigational drugs, ongoing research continues to elucidate its full therapeutic potential and mechanism of action in various disease states.

Formula: C₂₂H₂₆FN₃O₂

InChI: InChI=1S/C22H26FN3O2/c1-13-17(9-15(10-18(13)23)21(28)26-16-6-7-16)19-8-5-14(11-24-19)20(27)25-12-22(2,3)4/h5,8-11,16H,6-7,12H2,1-4H3,(H,25,27)(H,26,28)

InChI key: InChIKey=KKYABQBFGDZVNQ-UHFFFAOYSA-N

SMILES: CC=1C(=CC(C(NC2CC2)=O)=CC1F)C3=CC=C(C(NCC(C)(C)C)=O)C=N3

Synonyms:

• 3-Pyridinecarboxamide, 6-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-
• 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)nicotinamide
• 6-[5-[(Cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide
• Gsk-Ahab
• Gw 856553
• Gw 856553X
• Gw856553
• Losmapimod
• Sb 856553

Losmapimod (GW856553X)

CAS: 585543-15-3

Formula: C₂₂H₂₆FN₃O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 383.4591

Ref: IN-DA00ECDY

Losmapimod

CAS: 585543-15-3

Losmapimod

Purity: ≥98%

Molecular weight: 383.46g/mol

Ref: 54-BUP09862

Losmapimod

CAS: 585543-15-3

Losmapimod

Formula: C₂₂H₂₆FN₃O₂

Purity: 99.99% (Typical Value in Batch COA)

Color and Shape: white solid

Molecular weight: 383.46g/mol

Ref: 54-BISN0173

Losmapimod

CAS: 585543-15-3

Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).

Formula: C₂₂H₂₆FN₃O₂

Purity: 98.35% - 99.89%

Color and Shape: Solid

Molecular weight: 383.46

Ref: TM-T2277

Losmapimod

Controlled Product

CAS: 585543-15-3

Formula: C₂₂H₂₆FN₃O₂

Color and Shape: Neat

Molecular weight: 383.459

Ref: TR-L471000

Losmapimod-d6

Controlled Product

CAS: 585543-15-3

Formula: C₂₂H₂₀D₆FN₃O₂

Color and Shape: Neat

Molecular weight: 389.5

Ref: TR-L471002