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CAS 585543-15-3

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Losmapimod

Description:
Losmapimod is a small molecule inhibitor primarily known for its role as a selective inhibitor of p38 mitogen-activated protein kinase (MAPK). This compound has garnered attention in the field of pharmacology for its potential therapeutic applications, particularly in inflammatory diseases and conditions associated with chronic pain. Losmapimod exhibits a moderate to high degree of solubility in organic solvents, which is typical for many small molecule inhibitors. Its chemical structure features a pyridinyl moiety, contributing to its biological activity. The compound has been studied in various preclinical and clinical settings, demonstrating efficacy in modulating inflammatory responses. Additionally, Losmapimod's pharmacokinetic profile suggests it has a favorable absorption and distribution in biological systems, although its metabolism and excretion pathways are essential for understanding its overall safety and efficacy. As with many investigational drugs, ongoing research continues to elucidate its full therapeutic potential and mechanism of action in various disease states.
Formula:C22H26FN3O2
InChI:InChI=1S/C22H26FN3O2/c1-13-17(9-15(10-18(13)23)21(28)26-16-6-7-16)19-8-5-14(11-24-19)20(27)25-12-22(2,3)4/h5,8-11,16H,6-7,12H2,1-4H3,(H,25,27)(H,26,28)
InChI key:InChIKey=KKYABQBFGDZVNQ-UHFFFAOYSA-N
SMILES:CC=1C(=CC(C(NC2CC2)=O)=CC1F)C3=CC=C(C(NCC(C)(C)C)=O)C=N3
Synonyms:
  • 3-Pyridinecarboxamide, 6-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-
  • 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)nicotinamide
  • 6-[5-[(Cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide
  • Gsk-Ahab
  • Gw 856553
  • Gw 856553X
  • Gw856553
  • Losmapimod
  • Sb 856553
Found 7 products.