CAS 58579-51-4

Anagrelide hydrochloride

Description:

Anagrelide hydrochloride is a synthetic compound primarily used as a medication to treat essential thrombocythemia, a condition characterized by elevated platelet counts. It functions as a selective inhibitor of platelet aggregation and is known to reduce platelet production by acting on megakaryocytes in the bone marrow. The substance is a white to off-white crystalline powder, soluble in water and methanol, which facilitates its administration in a clinical setting. Anagrelide hydrochloride has a molecular formula that reflects its complex structure, and it is typically administered orally. Its pharmacokinetics involve rapid absorption, with peak plasma concentrations occurring within a few hours post-administration. The drug is metabolized primarily in the liver, and its elimination half-life allows for once or twice daily dosing. Common side effects may include headache, diarrhea, and palpitations, necessitating monitoring of patients for potential adverse reactions. Overall, Anagrelide hydrochloride represents a targeted therapeutic approach in managing disorders associated with high platelet counts.

Formula: C₁₀H₇Cl₂N₃O·ClH

InChI: InChI=1S/C10H7Cl2N3O.ClH/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7;/h1-2H,3-4H2,(H,13,14,16);1H

InChI key: InChIKey=TVWRQCIPWUCNMI-UHFFFAOYSA-N

SMILES: ClC1=C2C(NC=3N(C2)CC(=O)N3)=CC=C1Cl.Cl

Synonyms:

• 6,7-Dichloro-1,5-dihydroimidazo(2,1-b)-quinazolin-2(3H)-one monohydrochloride
• 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one Hydrochloride
• 6,7-dichloro-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one hydrochloride (1:1)
• Agrelin
• Agrylin
• Anagrelide hcl
• Bl 4162A
• Bmy 26538-01
• Imidazo[2,1-b]quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-, hydrochloride (1:1)
• Imidazo[2,1-b]quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-, monohydrochloride
• Anagrelide hydrochloride

Anagrelide hydrochloride

CAS: 58579-51-4

Formula: C₁₀H₈Cl₃N₃O

Purity: 99%

Color and Shape: Solid

Molecular weight: 292.5490

Ref: IN-DA00IAES

6,7-Dichloro-5,10-Dihydroimidazo[2,1-B]Quinazolin-2(3H)-One Hydrochloride

CAS: 58579-51-4

6,7-Dichloro-5,10-Dihydroimidazo[2,1-B]Quinazolin-2(3H)-One Hydrochloride

Formula: C₁₀H₈Cl₃N₃O

Purity: 99%

Molecular weight: 292.55

Ref: 54-OR1026209

Anagrelide HCl

CAS: 58579-51-4

Formula: C₁₀H₇Cl₂N₃O·HCl

Molecular weight: 256.09 36.46

Ref: 4Z-A-10317

Anagrelide hydrochloride

CAS: 58579-51-4

Anagrelide hydrochloride

Formula: C₁₀H₇Cl₂N₃O·HCl

Purity: ≥98%

Molecular weight: 292.55

Ref: 54-BUP10164

Anagrelide hydrochloride hydrate

CAS: 58579-51-4

Formula: C₁₀H₇Cl₂N₃O

Molecular weight: 256.09

Ref: 7W-GP7368

Anagrelide Hydrochloride

Controlled Product

CAS: 58579-51-4

Formula: C₁₀H₇Cl₂N₃O·ClH

Color and Shape: Neat

Molecular weight: 292.55

Ref: 86-MM3250.00

Anagrelide HCl

CAS: 58579-51-4

6,7-Dichloro-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one hydrochloride

Formula: C₁₀H₈Cl₃N₃O

Purity: 99%

Molecular weight: 292.55

Ref: IN-DG114292

Anagrelide hydrochloride

CAS: 58579-51-4

Anagrelide hydrochloride (BL4162A) serves as a treatment for essential thrombocytosis.

Formula: C₁₀H₇Cl₂N₃O·HCl

Purity: 99.58%

Color and Shape: White Solid

Molecular weight: 292.55

Ref: TM-T6390

Anagrelide Hydrochloride

CAS: 58579-51-4

Formula: C₁₀H₇Cl₂N₃OHCl

Molecular weight: 256.09 : 36.46

Ref: ST-EA-CP-A76019

Anagrelide Hydrochloride

Controlled Product

CAS: 58579-51-4

Applications Anagrelide Hydrochloride is a phosphodiesterase inhibitor with antiplatelet activity. Used as an antithrombocythemic. Potent PDE3 inhibitor.
References Fleming, J.S., et al.: Thromb. Res., 15, 373 (1979), Seiler, S., et al.: J. Pharmacol. Exp. Ther., 243, 767 (1984), Silverstein, M. N., et al.: N. Engl. J. Med., 318, 1292 (1988), Spencer, C.M., et al.: Drugs, 47, 809 (1994),

Formula: C₁₀H₇Cl₂N₃O·ClH

Color and Shape: Neat

Molecular weight: 292.55

Ref: TR-A637300

Anagrelide hydrochloride

CAS: 58579-51-4

Phosphodiesterase-III inhibitor; thrombocytopenic

Formula: C₁₀H₇Cl₂N₃O•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 292.55 g/mol

Ref: 3D-FD11668

Anagrelide HCl - Bio-X ™

CAS: 58579-51-4

Anagrelide is a thrombocytopenic drug that is used to treat thrombocythemia and related conditions. This drug works by decreasing the platelet count by suppressing transcription factors that are necessary for the maturation of platelets. This drug is also a phosphodiesterase III inhibitor.

Formula: C₁₀H₇Cl₂N₃O•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 292.55 g/mol

Ref: 3D-BD164174

6,7-Dichloro-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one hydrochloride

CAS: 58579-51-4

Formula: C₁₀H₈Cl₃N₃O

Purity: 95.0%

Molecular weight: 292.54

Ref: 10-F379100