CAS 587871-26-9

2-morpholin-4-yl-6-thianthren-1-yl-4H-pyran-4-one

Description:

2-Morpholin-4-yl-6-thianthren-1-yl-4H-pyran-4-one is a synthetic organic compound characterized by its unique molecular structure, which includes a pyran ring fused with a thianthrene moiety and a morpholine substituent. This compound typically exhibits properties such as moderate solubility in polar solvents and potential bioactivity, making it of interest in medicinal chemistry and drug development. The presence of the morpholine group may contribute to its pharmacological properties, potentially enhancing its interaction with biological targets. Additionally, the thianthrene component may impart specific electronic and steric characteristics, influencing its reactivity and stability. The compound's CAS number, 587871-26-9, allows for its identification in chemical databases and literature. Overall, 2-morpholin-4-yl-6-thianthren-1-yl-4H-pyran-4-one represents a class of compounds that may exhibit diverse applications in pharmaceuticals, particularly in the development of novel therapeutic agents. Further studies would be necessary to fully elucidate its biological activity and potential uses.

Formula: C₂₁H₁₇NO₃S₂

InChI: InChI=1/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2

SMILES: c1ccc2c(c1)Sc1cccc(c3cc(=O)cc(N4CCOCC4)o3)c1S2

Synonyms:

• 4H-Pyran-4-one, 2-(4-morpholinyl)-6-(1-thianthrenyl)-
• Ku-55933
• 2-(Morpholin-4-yl)-6-(thianthren-1-yl)-4H-pyran-4-one

KU-55933 (ATM Kinase Inhibitor)

CAS: 587871-26-9

Formula: C₂₁H₁₇NO₃S₂

Purity: 96%

Color and Shape: Solid

Molecular weight: 395.4946

Ref: IN-DA00E9P5

Ku-55933

CAS: 587871-26-9

Ku-55933

Purity: 97%

Molecular weight: 395.49g/mol

Ref: 54-BI12165

KU-55933

CAS: 587871-26-9

KU-55933

Purity: ≥95%

Molecular weight: 395.49g/mol

Ref: 54-BUP06384

KU-55933

CAS: 587871-26-9

Formula: C₂₁H₁₇NO₃S₂

Molecular weight: 395.49

Ref: 4Z-K-031029

KU-55933

CAS: 587871-26-9

KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.

Formula: C₂₁H₁₇NO₃S₂

Purity: 97.21% - >99.99%

Color and Shape: Solid

Molecular weight: 395.49

Ref: TM-T2685

KU 55933

Controlled Product

CAS: 587871-26-9

Applications KU 55933 is an ATM kinase inhibitor, which provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism, ultimately inhibiting calpain and cathepsin D.
References Chwastek, J.; Jantas, D.; Lason, W.: Int. J. Biochem. Cell Biol., 87, 38 (2017)

Formula: C₂₁H₁₇NO₃S₂

Color and Shape: Neat

Molecular weight: 395.49

Ref: TR-K660438

KU 55933

CAS: 587871-26-9

Inhibitor of ataxia telangiectasia mutated (ATM) kinase and AKT kinase with anti-cancer activity. ATM is a nuclear protein kinase and a signal transducer sensing DNA damage as well as controlling double strand DNA break (DSB) repair. It is a radiotherapy and chemotherapy sensitizer, especially in tumors sensitive to DNA alkylating agents (such as temozolomide). Moreover, KU 55933 inhibits phosphorylation of cytoplasmic AKT kinase, downregulates synthesis of cyclin D1 and induces cell cycle arrest in G1 phase.

Formula: C₂₁H₁₇NO₃S₂

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 395.06499

Ref: 3D-BK43330