KU 55933

CAS: 587871-26-9

Ref. 3D-BK43330

Product Information

• Name: KU 55933
• Synonyms: 2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one, 4H-Pyran-4-one, 2-(4-morpholinyl)-6-(1-thianthrenyl)-, Ku-55933
• CAS: 587871-26-9

Description

Inhibitor of ataxia telangiectasia mutated (ATM) kinase and AKT kinase with anti-cancer activity. ATM is a nuclear protein kinase and a signal transducer sensing DNA damage as well as controlling double strand DNA break (DSB) repair. It is a radiotherapy and chemotherapy sensitizer, especially in tumors sensitive to DNA alkylating agents (such as temozolomide). Moreover, KU 55933 inhibits phosphorylation of cytoplasmic AKT kinase, downregulates synthesis of cyclin D1 and induces cell cycle arrest in G1 phase.

• Brand: Biosynth

Chemical properties

• Molecular weight: 395.06499
• Formula: C₂₁H₁₇NO₃S₂
• Purity: Min. 95%
• Color/Form: White To Off-White Solid
• InChI: InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
• InChI key: InChIKey=XRKYMMUGXMWDAO-UHFFFAOYSA-N
• SMILES: O=c1cc(-c2cccc3c2Sc2ccccc2S3)oc(N2CCOCC2)c1