CAS 59-01-8: Kanamycin A

Description: Kanamycin A is an aminoglycoside antibiotic that is primarily used to treat bacterial infections, particularly those caused by Gram-negative bacteria. It is derived from the bacterium *Micromonospora kanamycetica*. Kanamycin A exhibits a broad spectrum of antibacterial activity and works by inhibiting protein synthesis in bacteria, leading to cell death. The compound is characterized by its complex structure, which includes multiple amino sugars and a 2-deoxystreptamine core. It is typically administered via injection or intravenously due to its poor absorption in the gastrointestinal tract. Kanamycin A is known for its potential nephrotoxicity and ototoxicity, necessitating careful monitoring of kidney function and hearing in patients receiving treatment. Additionally, resistance to kanamycin can develop, often through enzymatic modification by bacteria. Its use is generally reserved for specific infections, particularly in cases where other antibiotics are ineffective or contraindicated. Overall, kanamycin A remains an important tool in the antibiotic arsenal, particularly in treating multidrug-resistant infections.

Formula: C₁₈H₃₆N₄O₁₁

InChI: InChI=1S/C18H36N4O11/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17/h4-18,23-29H,1-3,19-22H2/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-/m1/s1

InChI key: InChIKey=SBUJHOSQTJFQJX-NOAMYHISSA-N

SMILES: OCC1OC(OC2C(O)C(OC3OC(CN)C(O)C(O)C3O)C(N)CC2N)C(O)C(N)C1O

Synonyms:

• (1S,2R,3R,4S,6R)-4,6-diamino-3-[(6-amino-6-deoxy-alpha-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
• 4))-2-Deoxy-Y-Alpha-D-Glucopyranosyl-(
• 4,6-Diamino-2-Hydroxy-1,3-Cyclohexane3,6’Diamino-3,6'-Dideoxydi-Alpha-D-Gluc
• 4,6-Diamino-2-Hydroxy-1,3-Cyclohexane3,6’Diamino-3,6’-Dideoxydi-Alpha-D-Glucos
• 4,6-Diamino-2-hydroxy-1,3-cyclohexane 3,6'-diamino-3,6'-dideoxydi-α-D-glucoside
• 4,6-Diamino-2-hydroxy-1,3-cyclohexane 3,6′-diamino-3,6′-dideoxydi-α-<span class="text-smallcaps">D</span>-glucoside
• 4,6-Diamino-3-[(6-Amino-6-Deoxyhexopyranosyl)Oxy]-2-Hydroxycyclohexyl 3-Amino-3-Deoxyhexopyranoside
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-
• D-Deoxydi
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-
• D-Streptamine,O-3-Amino-3-Deoxy-Alpha-D-Glucopyranosyl-(1.Fwdarw.6)-O-[6-Amin
• KM
• Kanacin
• Kanamicina
• Kanamycin A
• Kanamycin Base
• Kanamycine
• O-3-Amino-3-deoxy-α-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)]-2-deoxy-<smallcap>D</span>-streptamine
• O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine

Kanamycin Monosulfate

CAS: 25389-94-0 59-01-88063-07-8

• Formula: C₁₈H₃₆N₄O₁₁·H₂SO₄
• Purity: >94.0%(N)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 582.58

KanamycinA

CAS: 59-01-8

• Formula: C₁₈H₃₆N₄O₁₁
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 484.4986

Kanamycin A

CAS: 59-01-8

Kanamycin A (KanamycinA) is an aminoglycoside antibiotic with antibacterial and antiviral activity that inhibits bacterial …

• Formula: C₁₈H₃₆N₄O₁₁
• Purity: 99.59%
• Color and Shape: Crystals From Methanol + Ethanol Solid
• Molecular weight: 484.5

Kanamycin A

CAS: 59-01-8

• Purity: ≥98%
• Molecular weight: 484.5g/mol

Amikacin EP Impurity D

CAS: 59-01-8

• Formula: C₁₈H₃₆N₄O₁₁
• Color and Shape: White To Off-White Solid
• Molecular weight: 484.50

Kanamycin A

CAS: 59-01-8

Inhibitor of protein synthesis; aminoglycoside

• Formula: C₁₈H₃₆N₄O₁₁
• Purity: Min. 95%
• Color and Shape: White Clear Liquid
• Molecular weight: 484.5 g/mol