CAS 5909-24-0

Ethyl 4-chloro-2-(methylthio)-5-pyrimidinecarboxylate

Description:

Ethyl 4-chloro-2-(methylthio)-5-pyrimidinecarboxylate, with the CAS number 5909-24-0, is a chemical compound that belongs to the class of pyrimidine derivatives. It features a pyrimidine ring substituted with a chloro group at the 4-position and a methylthio group at the 2-position, along with an ethyl ester functional group at the carboxylic acid position. This compound is typically characterized by its moderate to low solubility in water, while being more soluble in organic solvents such as ethanol and dichloromethane. Its structure suggests potential biological activity, making it of interest in pharmaceutical research. The presence of the chloro and methylthio substituents can influence its reactivity and interaction with biological targets. Ethyl 4-chloro-2-(methylthio)-5-pyrimidinecarboxylate may be synthesized through various organic reactions, and its derivatives could exhibit diverse pharmacological properties, including antimicrobial or anti-inflammatory activities. Proper handling and storage are essential due to its chemical nature, and safety data sheets should be consulted for specific safety guidelines.

Formula: C₈H₉ClN₂O₂S

InChI: InChI=1S/C8H9ClN2O2S/c1-3-13-7(12)5-4-10-8(14-2)11-6(5)9/h4H,3H2,1-2H3

InChI key: InChIKey=SNNHLSHDDGJVDM-UHFFFAOYSA-N

SMILES: C(OCC)(=O)C=1C(Cl)=NC(SC)=NC1

Synonyms:

• 2-Methylthio-4-chloro-5-ethoxycarbonylpyrimidine
• 4-Chloro-2-(methylthio)-5-pyrimidinecarboxylic acid ethyl ester
• 4-Chloro-2-(methylthio)pyrimidin-5-carboxylic acid ethyl ester
• 4-Chloro-2-Methylthio-5-Pyrimidnecarboxylat
• 4-Chloro-2-methane-sulfanylpyrimidine-5-carboxylic Acid Ethyl Ester
• 4-Chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester
• 4-Chloro-2-methanethiopyrimidine-5-carboxylic acid ethyl ester
• 4-Chloro-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester
• 4-Chloro-2-methylsulfanylpyrimidine-5-carboxylic acid ethyl ester
• 4-Chloro-2-methylthio-5-carbethoxypyrimidine
• 4-Chloro-5-Ethoxycarbonyl-2-Methylthiopyrimidine
• 4-Chloro-5-carbethoxy-2-methylthiopyrimidine
• 5-Pyrimidinecarboxylic acid, 4-chloro-2-(methylthio)-, ethyl ester
• Ethyl 4-Chloro-2-(Methylsulfanyl)Pyrimidine-5-Carboxylate
• Ethyl 4-Chloro2-methylthiopyrimidine-5-carboxylate
• Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate
• Ethyl 4-chloro-2-methylsulfanyl-5-pyrimidinecarboxylate
• Ethyl 4-chloro-2-methylthio-5-pyrimidine carboxylate
• Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate
• NSC 123534

Ethyl 4-Chloro-2-(methylthio)pyrimidine-5-carboxylate

CAS: 5909-24-0

Formula: C₈H₉ClN₂O₂S

Purity: >97.0%(GC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 232.68

Ref: 3B-E0841

Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate, 98%

CAS: 5909-24-0

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₈H₉ClN₂O₂S

Purity: 98%

Color and Shape: White to cream, powder

Molecular weight: 232.68

Ref: 02-B22429

Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate

CAS: 5909-24-0

Formula: C₈H₉ClN₂O₂S

Purity: 96%

Color and Shape: Solid

Molecular weight: 232.6873

Ref: IN-DA00371D

Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate

CAS: 5909-24-0

Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate

Formula: C₈H₉ClN₂O₂S

Purity: 98%

Color and Shape: colourless to faint yellow crystalline solid

Molecular weight: 232.69g/mol

Ref: 54-OR6605

Avanafil Impurity 61

CAS: 5909-24-0

Formula: C₈H₉ClN₂O₂S

Molecular weight: 232.68

Ref: 4Z-A-2967

Ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate

CAS: 5909-24-0

Formula: C₈H₉ClN₂O₂S

Purity: 96%

Color and Shape: Solid

Molecular weight: 232.68

Ref: 10-F005213

Ethyl 4-Chloro-2-methylthiopyrimidine-5-carboxylate

Controlled Product

CAS: 5909-24-0

Applications A pyrimidine derivative as inhibitor of Streptococcus faecium, Lactobacillus casei, and Pediococcus cerevisiae.
References Coats, E.A., et al.: Eur. J. Med. Chem., 14, 261 (1979),

Formula: C₈H₉ClN₂O₂S

Color and Shape: Neat

Molecular weight: 232.69

Ref: TR-E902000

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate

CAS: 5909-24-0

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate is a potent inhibitor of tyrosine kinases. It has been shown to inhibit the growth of cancer cells in vitro and in vivo. This drug has also been shown to be effective against various types of human cancer cell lines, such as human leukemia cells and myeloma cells. Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate inhibits the production of proteins vital for cell division by binding to tyrosine kinase. This binding prevents the formation of an enzyme complex with other enzymes that are required for protein synthesis, thereby inhibiting protein synthesis and cell division. The compound has also been shown to be a highly selective inhibitor of amines, which may contribute to its pharmacological effects.

Formula: C₈H₉ClN₂O₂S

Purity: Min. 95%

Molecular weight: 232.69 g/mol

Ref: 3D-FE15899

Avanafil Impurity 61

CAS: 5909-24-0

Formula: C₈H₉ClN₂O₂S

Molecular weight: 232.68

Ref: ST-EA-CP-A84036