CAS 59198-70-8

Diflucortolone valerate

Description:

Diflucortolone valerate is a synthetic corticosteroid used primarily for its anti-inflammatory and immunosuppressive properties. It is characterized by its ability to reduce inflammation and alleviate symptoms associated with various dermatological conditions, such as eczema and psoriasis. The compound is typically formulated as a topical ointment or cream, allowing for localized treatment with minimal systemic absorption. Its mechanism of action involves the inhibition of inflammatory mediators and modulation of immune responses. Diflucortolone valerate is known for its potency, which is generally classified as a mid-strength corticosteroid, making it effective for moderate to severe inflammatory skin disorders. Additionally, it has a favorable safety profile when used as directed, although potential side effects may include skin irritation or atrophy with prolonged use. The chemical structure includes a valerate ester, contributing to its pharmacokinetic properties and enhancing its therapeutic efficacy. Overall, Diflucortolone valerate is a valuable option in dermatological therapy, providing relief from inflammation while minimizing adverse effects when used appropriately.

Formula: C₂₇H₃₆F₂O₅

InChI: InChI=1S/C27H36F2O5/c1-5-6-7-23(33)34-14-21(31)24-15(2)10-17-18-12-20(28)19-11-16(30)8-9-26(19,4)27(18,29)22(32)13-25(17,24)3/h8-9,11,15,17-18,20,22,24,32H,5-7,10,12-14H2,1-4H3/t15-,17+,18+,20+,22+,24-,25+,26+,27+/m1/s1

InChI key: InChIKey=HHJIUUAMYGBVSD-YTFFSALGSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@@H](C(COC(CCCC)=O)=O)[C@H](C)C3)[H])(C[C@H](F)C=4[C@]2(C)C=CC(=O)C4)[H]

Synonyms:

• (6Alpha,11Beta,16Alpha)-6,9-Difluoro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl Pentanoate
• (6alpha,11beta,16alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl valerate
• (6α,11β,16α)-6,9-Difluoro-11-hydroxy-16-methyl-21-[(1-oxopentyl)oxy]pregna-1,4-diene-3,20-dione
• 59198-70-8
• Afusona
• Diflucortolone 21-valerate
• Diflucortolone valerate (JAN)
• Neriforte
• Nerisona
• Nerisone
• Nerisone Forte
• Pentanoic Acid, (6Alpha,11Beta,16Alpha)-6,9-Difluoro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl Ester
• Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11-hydroxy-16-methyl-21-[(1-oxopentyl)oxy]-, (6α,11β,16α)-
• Temetex
• Texmeten
• Travazol
• Youtolon[Tatsumi]

Diflucortolone valerate

CAS: 59198-70-8

Diflucortolone valerate

Formula: C₂₇H₃₆F₂O₅

Purity: 98.8%

Color and Shape: White. To. Off-White

Molecular weight: 478.25308

Ref: 47-401

Diflucortolone Valerate

CAS: 59198-70-8

Diflucortolone Valerate

Formula: C₂₇H₃₆F₂O₅

Purity: 97%

Molecular weight: 478.57

Ref: 54-PC108676

Diflucortolone 21-valerate

CAS: 59198-70-8

Formula: C₂₇H₃₆F₂O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 478.5685

Ref: IN-DA00JNWY

Diflucortolone valerate

CAS: 59198-70-8

Diflucortolone valerate

Formula: C₂₇H₃₆F₂O₅

Purity: ≥98%

Molecular weight: 478.57

Ref: 54-BUP13293

Diflucortolone Valerate

Controlled Product

CAS: 59198-70-8

Formula: C₂₇H₃₆F₂O₅

Color and Shape: Neat

Molecular weight: 478.57

Ref: 86-MM0600.00

Diflucortolone valerate (Standard)

CAS: 59198-70-8

Diflucortolone valerate (Standard) is the standard substance of Diflucortolone valerate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Diflucortolone valerate (Diflucortolone 21-valerate) is a corticosteroid esterified with valeric acid. It helps to reduce itching, redness, and swelling.

Formula: C₂₇H₃₆F₂O₅

Color and Shape: Solid

Molecular weight: 478.57

Ref: TM-TMSM-0968

Diflucortolone Valerate

CAS: 59198-70-8

Color and Shape: Neat

Ref: 61-FOR0600.00

Diflucortolone valerate

CAS: 59198-70-8

Diflucortolone valerate (Diflucortolone 21-valerate) is a corticosteroid esterified with valeric acid. It helps to reduce itching, redness, and swelling.

Formula: C₂₇H₃₆F₂O₅

Purity: 99.05%

Color and Shape: Solid

Molecular weight: 478.57

Ref: TM-T5000

Difluocortolone Valerate

CAS: 59198-70-8

Formula: C₂₇H₃₆F₂O₅

Molecular weight: 478.58

Ref: 4Z-F-071004

Diflucortolone 21-Valerate

Controlled Product

CAS: 59198-70-8

Applications The 9α-fluoro derivative of Fluocortolone (F500500). Anti-inflammmatory.
References Kieslich, et al.: Arzneim.-Forsch., 26, 1462 (1976),

Formula: C₂₇H₃₆F₂O₅

Color and Shape: Neat

Molecular weight: 478.57

Ref: TR-D445620

Diflucortolone valerate

Controlled Product

CAS: 59198-70-8

Diflucortolone valerate is a corticosteroid that is used to treat inflammatory skin diseases. It is a prodrug that is hydrolyzed in vivo to diflucortolone, its active form. Diflucortolone valerate has been shown to be effective against alopecia areata and mycological skin infections. The optimum concentration of this drug for treating these conditions is 0.5% or less, with side effects such as erythema, scaling, and burning at the application site occurring at higher concentrations. Diflucortolone valerate also has broad-spectrum antimicrobial activity against bacteria and fungi, including methicillin-resistant Staphylococcus aureus (MRSA) isolates.

Formula: C₂₇H₃₆F₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 478.57 g/mol

Ref: 3D-FD65004

Diflucortolone Valerate

CAS: 59198-70-8

Formula: C₂₇H₃₆F₂O₅

Molecular weight: 478.58

Ref: ST-EA-CP-D115001

Diflucortolone valerate impurity standard

CAS: 59198-70-8

Diflucortolone valerate impurity standard

Color and Shape: Off White Solid

Ref: 47-397

Diflucortolone Valerate RS

CAS: 59198-70-8

Color and Shape: White

Ref: 2K-1068500021