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CAS 593-84-0

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Guanidine thiocyanate

Description:
Guanidine thiocyanate is a colorless, hygroscopic solid with the chemical formula CH5N3S. It is primarily known for its role as a chaotropic agent, which disrupts hydrogen bonding in water and proteins, making it useful in molecular biology, particularly in the extraction of nucleic acids. The substance is soluble in water and has a relatively high solubility in organic solvents, which enhances its utility in various biochemical applications. Guanidine thiocyanate is also characterized by its ability to denature proteins, facilitating the release of nucleic acids from cellular structures. It has a relatively low toxicity but should be handled with care due to its potential irritant properties. In laboratory settings, it is often used in conjunction with phenol and chloroform for RNA and DNA isolation. Its stability under a range of conditions makes it a valuable reagent in research and diagnostic applications. Proper storage in a cool, dry place is recommended to maintain its efficacy.
Formula:CH5N3·CHNS
InChI:InChI=1S/CH5N3.CHNS/c2-1(3)4;2-1-3/h(H5,2,3,4);3H
InChI key:InChIKey=ZJYYHGLJYGJLLN-UHFFFAOYSA-N
SMILES:C(#N)S.C(=N)(N)N
Synonyms:
  • 2-(Cyanosulfanyl)Guanidine
  • Buffer AVL
  • Buffer ML
  • Buffer MTL
  • Buffer RLT
  • GTC
  • Guanidine Thiocyanate (1:1)
  • Guanidine isothiocyanate
  • Guanidine, monothiocyanate
  • Guanidinium Isothiocyanate
  • See more synonyms
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