CAS 594839-88-0

Tafamidis

Description:

Tafamidis is a small molecule drug primarily used in the treatment of transthyretin amyloidosis (ATTR), a condition characterized by the accumulation of misfolded transthyretin protein in tissues. It functions as a stabilizer of the tetrameric form of transthyretin, thereby preventing its dissociation into monomers that can misfold and aggregate. Tafamidis is known for its high selectivity and affinity for the transthyretin protein, which contributes to its therapeutic efficacy. The substance is typically administered orally and has been shown to slow the progression of the disease and improve quality of life in affected patients. In terms of its chemical properties, tafamidis has a molecular formula that reflects its complex structure, which includes aromatic rings and various functional groups that contribute to its pharmacological activity. The drug is generally well-tolerated, with a safety profile that has been established through clinical trials. Overall, tafamidis represents a significant advancement in the management of ATTR, offering hope for patients with this challenging condition.

Formula: C₁₄H₇Cl₂NO₃

InChI: InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19)

InChI key: InChIKey=TXEIIPDJKFWEEC-UHFFFAOYSA-N

SMILES: ClC=1C=C(C=2OC=3C(N2)=CC=C(C(O)=O)C3)C=C(Cl)C1

Synonyms:

• 6-Benzoxazolecarboxylic acid, 2-(3,5-dichlorophenyl)-
• 2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid
• 6-Benzoxazolecarboxylic acid, 2-(3,5-dichlorophenyl)-
• 2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid
• Tafamidis
• Vyndamax
• Fx 1006
• FX-1006A;FX1006A;FX 1006A
• Fx-1006A
• Tafamidis free acid, 2-(3,5-dichlorophenyl)-6-benzoxazole carboxylic acid
• Fx1006A
• PF-06291826(Tafamidis)
• Tafamidis(Fx 1006)
• Tafamidis free acid
• Fx 1006A

Tafamidis

CAS: 594839-88-0

Tafamidis

Purity: ≥98%

Molecular weight: 308.12g/mol

Ref: 54-BUP13265

Tafamidis

CAS: 594839-88-0

Formula: C₁₄H₇Cl₂NO₃

Color and Shape: Off-White Solid

Molecular weight: 308.11

Ref: 4Z-T-302001

Tafamidis-d3

CAS: 594839-88-0

Formula: C₁₄H₄D₃Cl₂NO₃

Color and Shape: White To Off-White Solid

Molecular weight: 311.13

Ref: 4Z-T-302003

Tafamidis

CAS: 594839-88-0

Color and Shape: Neat

Ref: 86-MM3971.00

Tafamidis

CAS: 594839-88-0

Tafamidis stabilizes TTR, preventing amyloid buildup; binds with negative cooperativity (Kd1: 3 nM, Kd2: 278 nM); treats familial amyloid polyneuropathy.

Formula: C₁₄H₇Cl₂NO₃

Purity: 99.34% - 99.65%

Color and Shape: Solid

Molecular weight: 308.12

Ref: TM-T4565

2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid

CAS: 594839-88-0

2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid (XZP) is a diagnostic agent used in the diagnosis of certain diseases. XZP binds to the matrix metalloproteinases and inhibits their activity, which has been shown to reduce the effects of these enzymes on collagen fibers. This inhibition can be demonstrated using a titration calorimetry technique. The drug is also a potential therapeutic agent for congestive heart failure, as it can stimulate cardiac natriuretic peptide levels and reduce transthyretin levels. XZP has also been shown to be an effective adjunct therapy in vancomycin therapy for treatment of tubulointerstitial injury in rats.

Formula: C₁₄H₇Cl₂NO₃

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 308.12 g/mol

Ref: 3D-FD27988