CAS 59831-65-1

Halopemide

Description:

Halopemide is a chemical compound classified as a benzamide derivative, primarily known for its application in the field of pharmacology. It is recognized for its potential use as an antipsychotic agent, exhibiting properties that may influence neurotransmitter systems in the brain, particularly those involving dopamine and serotonin. The molecular structure of Halopemide includes a halogenated aromatic ring, which contributes to its biological activity. It is typically characterized by its moderate solubility in organic solvents and limited solubility in water, which can affect its bioavailability and pharmacokinetics. The compound has been studied for its effects on various neurological conditions, although its clinical use may be limited compared to other antipsychotics. Safety and efficacy profiles are essential considerations in its application, and ongoing research may further elucidate its therapeutic potential and mechanisms of action. As with any pharmaceutical compound, proper handling and adherence to safety guidelines are crucial due to potential side effects and interactions with other medications.

Formula: C₂₁H₂₂ClFN₄O₂

InChI: InChI=1/C21H22ClFN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)

InChI key: NBHPRWLFLUBAIE-UHFFFAOYSA-N

SMILES: c1cc(ccc1C(=O)NCCN1CCC(CC1)n1c2ccc(cc2nc1O)Cl)F

Synonyms:

• 59831-65-1
• N-[2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-4-fluorobenzamide
• N-{2-[4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl}-4-fluorobenzamide

Halopemide

CAS: 59831-65-1

Halopemide

Formula: C₂₁H₂₂ClFN₄O₂

Purity: 96.5%

Molecular weight: 416.88

Ref: 54-BUP14311

N-[2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-4-fluorobenzamide

CAS: 59831-65-1

Formula: C₂₁H₂₂ClFN₄O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 416.8764

Ref: IN-DA00EBLO

Halopemide

Controlled Product

CAS: 59831-65-1

Applications Halopemide acts as a small molecule inhibitor for phospholipase D (PLD), an important phosphlipid metabolism regulator which may be useful in the therapeutic treatment of Alzheimer’s Disease and other brain disorders.
References Lindsley, C. et al.: Neuropsychopharm., 37, 301 (2012);

Formula: C₂₁H₂₂ClFN₄O₂

Color and Shape: Neat

Molecular weight: 416.876

Ref: TR-H103695

Halopemide

CAS: 59831-65-1

Halopemide is a potent inhibitor of PLD (IC50 = 220 and 310 nM for human PLD1 and PLD2).

Formula: C₂₁H₂₂ClFN₄O₂

Purity: 96.57%

Color and Shape: Solid

Molecular weight: 416.876

Ref: TM-T15461