CAS 59865-13-3

Cyclosporine A

Description:

Cyclosporine A is a cyclic polypeptide composed of 11 amino acids, primarily known for its immunosuppressive properties. It is produced by the fungus Tolypocladium inflatum and is widely used in clinical settings, particularly in organ transplantation and autoimmune diseases, to prevent organ rejection and manage conditions like rheumatoid arthritis. The substance functions by inhibiting the activation of T-lymphocytes, thereby reducing the immune response. Cyclosporine A is lipophilic, which affects its absorption and distribution in the body; it is typically administered orally or intravenously. Its pharmacokinetics can be influenced by various factors, including food intake and concurrent medications, necessitating careful monitoring of blood levels to avoid toxicity. Adverse effects may include nephrotoxicity, hypertension, and increased susceptibility to infections. Due to its complex interactions and side effects, cyclosporine A requires careful management and dosage adjustments based on individual patient response and clinical context.

Formula: C₆₂H₁₁₁N₁₁O₁₂

InChI: InChI=1/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

Synonyms:

• Cyclosporina
• Cyclosporine
• Cyclosporin
• Restasis
• cyclosporin A
• Antibiotic S 7481F1
• 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• 1: PN: US6686454 SEQID: 1 claimed protein
• 7: PN: WO0002548 PAGE: 30 claimed protein
• Arpimune ME
• Cicloral
• Cicloral (antibiotic)
• Ciclosporin
• Cipol N
• Consupren
• Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
• Debio088
• Equoral
• Gengraf
• Neoplanta
• Neoral
• Nsc 290193
• Ol 27-400
• Papilock Mini
• Ramihyphin A
• Sandimmun
• Sandimmune
• Sandimmune Neoral
• Sang-35
• SangCyA
• Sdz-Oxl 400
• Sigmasporin Microoral
• S-Neoral
• Zinograf ME

Cyclosporin A

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Formula: C₆₂H₁₁₁N₁₁O₁₂

Color and Shape: Neat

Molecular weight: 1202.61

Ref: TR-C988900

Cyclosporin A-d4 (Major)

Controlled Product

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Formula: C₆₂H₁₀₇D₄N₁₁O₁₂

Color and Shape: Neat

Molecular weight: 1206.66

Ref: TR-C988902

Cyclosporin A-13C2,d4 (Major)

Controlled Product

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Formula: C₂C₆₀D₄H₁₀₇N₁₁O₁₂

Color and Shape: Neat

Molecular weight: 1208.62

Ref: TR-C988901

Cyclosporin A

CAS: 59865-13-3

Binds cyclophilin D and inhibits calcineurin; immunosuppressant

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purity: Min. 98.5 Area-%

Color and Shape: White Powder

Molecular weight: 1,202.61 g/mol

Ref: 3D-FC20749

Cyclosporin A - Bio-X ™

CAS: 59865-13-3

Cyclosporin A (CsA) is a cyclic undecapeptide that is extracted from the fungus Tolypocladium inflatum. CsA is used as an immunosuppressive drug to prevent rejection of transplanted organs and to treat autoimmune diseases such as rheumatoid arthritis and psoriasis. CsA works by binding to a protein called cyclophilin D, which is a component of the enzyme calcineurin. Calcineurin is an important enzyme involved in the activation of immune cells, and by binding to cyclophilin D, CsA inhibits its activity. This leads to the inhibition of T-cell activation and the suppression of the immune response. Cyclosporin A has has been rpeorted to exhibit some nephrotoxicity, hypertension and also increases the risk of infections and tumors when used in transplantation

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 1,202.61 g/mol

Ref: 3D-BC164336

Everolimus, Cyclosporine and Tacrolimus Mix Standard

Controlled Product

CAS: 104987-11-3, 159351-69-6, 59865-13-3

Formula: MixtureVisitourWebsite

Color and Shape: Mixture

Molecular weight: Mixture - Visit our Website

Ref: TR-E608165