CAS 59865-16-6

Isocyclosporin A

Description:

Isocyclosporin A is a cyclic peptide and a derivative of cyclosporin A, which is known for its immunosuppressive properties. It is primarily characterized by its unique cyclic structure, consisting of 11 amino acids linked in a specific sequence that contributes to its biological activity. Isocyclosporin A exhibits a high degree of lipophilicity, which influences its solubility and permeability across biological membranes. This compound is notable for its ability to inhibit T-cell activation and proliferation, making it valuable in transplant medicine and autoimmune disease treatment. The mechanism of action involves binding to cyclophilin, leading to the inhibition of calcineurin, a critical enzyme in T-cell signaling pathways. Additionally, Isocyclosporin A may have varying pharmacokinetic properties compared to its parent compound, affecting its therapeutic efficacy and safety profile. As with many immunosuppressants, careful monitoring is essential to manage potential side effects, including increased susceptibility to infections and organ toxicity. Overall, Isocyclosporin A represents an important compound in the field of immunology and pharmacology.

Formula: C₆₂H₁₁₁N₁₁O₁₂

InChI: InChI=1/C62H111N11O12/c1-25-27-28-40(15)52-50(63-18)56(78)66-43(26-2)58(80)68(19)33-48(74)69(20)44(29-34(3)4)55(77)67-49(38(11)12)61(83)70(21)45(30-35(5)6)54(76)64-41(16)53(75)65-42(17)57(79)71(22)46(31-36(7)8)59(81)72(23)47(32-37(9)10)60(82)73(24)51(39(13)14)62(84)85-52/h25,27,34-47,49-52,63H,26,28-33H2,1-24H3,(H,64,76)(H,65,75)(H,66,78)(H,67,77)/b27-25-

SMILES: C/C=C\CC(C)C1C(C(=NC(CC)C(=O)N(C)CC(=O)N(C)C(CC(C)C)C(=NC(C(C)C)C(=O)N(C)C(CC(C)C)C(=NC(C)C(=NC(C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(C(C)C)C(=O)O1)O)O)O)O)NC

Synonyms:

• 30-ethyl-4,7,10,12,15,19,25,28-octamethyl-33-(methylamino)-3,21-bis(1-methylethyl)-34-[(3Z)-1-methylpent-3-en-1-yl]-6,9,18,24-tetrakis(2-methylpropyl)-1-oxa-4,7,10,13,16,19,22,25,28,31-decaazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone

Ciclosporin EP Impurity C (Iso Cyclosporin A)

CAS: 59865-16-6

Formula: C₆₂H₁₁₁N₁₁O₁₂

Color and Shape: Off-White Solid

Molecular weight: 1202.64

Ref: 4Z-PC-547

Iso Cyclosporin A

Controlled Product

CAS: 59865-16-6

Stability Hygroscopic
Applications Cyclosporin A (C988900) impurity.
References Oliyai, R., et al.: Pharm. Res., 12, 323 (1995), Hermann, M., et al.: J. Pharm. Biomed. Anal., 30, 1263 (2002), Johnston, A., et al.: Ther. Drug Monit., 25, 167

Formula: C₆₂H₁₁₁N₁₁O₁₂

Color and Shape: Neat

Molecular weight: 1202.61

Ref: TR-I811500

Cyclosporin EP Impurity C

CAS: 59865-16-6

Formula: C₆₂H₁₁₁N₁₁O₁₂

Molecular weight: 1202.6

Ref: ST-EA-CP-C162003

Isocyclosporin A

CAS: 59865-16-6

Isocyclosporin A is a rearranged degradation product. It is formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions.

Formula: C₆₂H₁₁₁N₁₁O₁₂

Color and Shape: Solid

Molecular weight: 1202.61

Ref: TM-T19785

Isocyclosporin A

CAS: 59865-16-6

Isocyclosporin A is a cyclic peptide that belongs to the group of fatty acid containing compounds. It has been found to be stable in hydrochloric acid and to have a low melting point. The compound contains an amide functional group, which can be identified by spectroscopic methods. Isocyclosporin A is fluorescent and the fluorescence intensity can be measured using a fluorescence assay. Isocyclosporin A also has an extractant that is used for purification of this compound from plasma proteins. This extractant uses a fluorescence assay as well as hplc methods to measure the amount of protein contained in the sample.

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,202.61 g/mol

Ref: 3D-FC20750

Isocyclosporin A

CAS: 59865-16-6

Lactams, nesoi

Formula: C₆₂H₁₁₁N₁₁O₁₂

Color and Shape: White Off-White Powder

Molecular weight: 1201.84137

Ref: 45-1A03320