CAS 59865-16-6
:Isocyclosporin A
Description:
Isocyclosporin A is a cyclic peptide and a derivative of cyclosporin A, which is known for its immunosuppressive properties. It is primarily characterized by its unique cyclic structure, consisting of 11 amino acids linked in a specific sequence that contributes to its biological activity. Isocyclosporin A exhibits a high degree of lipophilicity, which influences its solubility and permeability across biological membranes. This compound is notable for its ability to inhibit T-cell activation and proliferation, making it valuable in transplant medicine and autoimmune disease treatment. The mechanism of action involves binding to cyclophilin, leading to the inhibition of calcineurin, a critical enzyme in T-cell signaling pathways. Additionally, Isocyclosporin A may have varying pharmacokinetic properties compared to its parent compound, affecting its therapeutic efficacy and safety profile. As with many immunosuppressants, careful monitoring is essential to manage potential side effects, including increased susceptibility to infections and organ toxicity. Overall, Isocyclosporin A represents an important compound in the field of immunology and pharmacology.
Formula:C62H111N11O12
InChI:InChI=1/C62H111N11O12/c1-25-27-28-40(15)52-50(63-18)56(78)66-43(26-2)58(80)68(19)33-48(74)69(20)44(29-34(3)4)55(77)67-49(38(11)12)61(83)70(21)45(30-35(5)6)54(76)64-41(16)53(75)65-42(17)57(79)71(22)46(31-36(7)8)59(81)72(23)47(32-37(9)10)60(82)73(24)51(39(13)14)62(84)85-52/h25,27,34-47,49-52,63H,26,28-33H2,1-24H3,(H,64,76)(H,65,75)(H,66,78)(H,67,77)/b27-25-
InChI key:QEKLELUAISGHEL-CGLBZJNRSA-N
SMILES:C/C=C\CC(C)C1C(C(=NC(CC)C(=O)N(C)CC(=O)N(C)C(CC(C)C)C(=NC(C(C)C)C(=O)N(C)C(CC(C)C)C(=NC(C)C(=NC(C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(C(C)C)C(=O)O1)O)O)O)O)NC
Synonyms:- 30-ethyl-4,7,10,12,15,19,25,28-octamethyl-33-(methylamino)-3,21-bis(1-methylethyl)-34-[(3Z)-1-methylpent-3-en-1-yl]-6,9,18,24-tetrakis(2-methylpropyl)-1-oxa-4,7,10,13,16,19,22,25,28,31-decaazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
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Isocyclosporin A
CAS:Lactams, nesoiFormula:C62H111N11O12·C2HF3O2Color and Shape:White Off-White PowderMolecular weight:1201.84137Isocyclosporin A
CAS:Isocyclosporin AFormula:C62H111N11O12Purity:95%Color and Shape:SolidMolecular weight:1202.61Ciclosporin EP Impurity C (Iso Cyclosporin A)
CAS:Formula:C62H111N11O12Color and Shape:Off-White SolidMolecular weight:1202.64Iso Cyclosporin A
CAS:Controlled ProductStability Hygroscopic
Applications Cyclosporin A (C988900) impurity.
References Oliyai, R., et al.: Pharm. Res., 12, 323 (1995), Hermann, M., et al.: J. Pharm. Biomed. Anal., 30, 1263 (2002), Johnston, A., et al.: Ther. Drug Monit., 25, 167Formula:C62H111N11O12Color and Shape:NeatMolecular weight:1202.61Isocyclosporin A
CAS:Isocyclosporin A is a rearranged degradation product. It is formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions.Formula:C62H111N11O12Color and Shape:SolidMolecular weight:1202.6112Isocyclosporin A
CAS:Isocyclosporin A is a cyclic peptide that belongs to the group of fatty acid containing compounds. It has been found to be stable in hydrochloric acid and to have a low melting point. The compound contains an amide functional group, which can be identified by spectroscopic methods. Isocyclosporin A is fluorescent and the fluorescence intensity can be measured using a fluorescence assay. Isocyclosporin A also has an extractant that is used for purification of this compound from plasma proteins. This extractant uses a fluorescence assay as well as hplc methods to measure the amount of protein contained in the sample.Formula:C62H111N11O12Purity:Min. 95%Color and Shape:PowderMolecular weight:1,202.61 g/mol
