CAS 59973-80-7

(Z)-5-Fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-indene-3-acetic acid

Description:

(Z)-5-Fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-indene-3-acetic acid, with the CAS number 59973-80-7, is a synthetic organic compound characterized by its unique structural features. It contains a fluorine atom, a methyl group, and a methylsulfonyl group, contributing to its potential biological activity. The indene core structure is notable for its aromatic properties, which can influence the compound's reactivity and interactions with biological targets. This compound is likely to exhibit moderate to high lipophilicity due to its hydrophobic regions, which may affect its solubility and permeability in biological systems. The presence of the acetic acid functional group suggests potential for ionization at physiological pH, impacting its pharmacokinetics. Additionally, the (Z) configuration indicates a specific geometric arrangement around the double bond, which can significantly influence the compound's biological activity and interactions. Overall, this compound may be of interest in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific biological pathways.

Formula: C₂₀H₁₇FO₄S

InChI: InChI=1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

InChI key: InChIKey=MVGSNCBCUWPVDA-MFOYZWKCSA-N

SMILES: C(C(O)=O)C=1C=2C(/C(=C\C3=CC=C(S(C)(=O)=O)C=C3)/C1C)=CC=C(F)C2

Synonyms:

• (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic acid
• 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-, (1Z)-
• 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-, (Z)-
• Aposulind
• Aptosyn
• Exisulind
• Fgn-1
• Prevatac(former Brand Name)
• Prevatec
• Sulindac sulfone
• cis-5-Fluoro-2-methyl-1-[p-methylsulfonylbenzylidenyl]indene-3-acetic acid
• 5-Fluoro-2-methyl-1-[(Z)-4-(methylsulfonyl)benzylidene]-1H-indene-3-acetic acid
• Unii-K619iig2R9
• (Z)-5-Fluoro-2-Methyl-1-[[4-(Methylsulfonyl)phenyl]Methylene]-1H-indene-3-acetic Acid
• APTOSYN/EXISULIND
• Ccris 7242
• Sulindac EP Impurity B (Sulindac USP Related Compound B, Sulindac Sulfone)
• Sulindac Impurity 2（Sulindac EP Impurity B）
• (Z)-Sulindac Sulfone
• Sulindac EP Impurity B/ Sulindac Related Compound B ((Z)-Sulindac Sulfone)
• (Z)-5-FLUORO-2-METHYL-1[P-(METHYLSULFONYL)BENZYLIDENE]INDENE-3-ACETIC ACID
• Sulindac Related Compound B ((Z)-2-{5-fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3- (1642020)
• Sulindac EP Impurity B (Sulindac Sulfone)
• Sulindac USP Related Compound B

Sulindac Related Compound B ((Z)-2-{5-fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3-yl}acetic acid)

CAS: 59973-80-7

Other aromatic organo-sulfur compounds (excluding pesticides)

Formula: C₂₀H₁₇FO₄S

Color and Shape: Yellow Crystalline Powder

Molecular weight: 372.08316

Ref: 45-1642020

1H-Indene-3-acetic acid,5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-, (1Z)-

CAS: 59973-80-7

Formula: C₂₀H₁₇FO₄S

Purity: 97%

Color and Shape: Solid

Molecular weight: 372.4100

Ref: IN-DA00EC0N

Exisulind

CAS: 59973-80-7

Exisulind

Purity: ≥95%

Molecular weight: 372.41g/mol

Ref: 54-BUP06388

Sulindac EP Impurity B (Sulindac USP Related Compound B, Sulindac Sulfone)

CAS: 59973-80-7

Formula: C₂₀H₁₇FO₄S

Color and Shape: Yellow Solid

Molecular weight: 372.41

Ref: 4Z-S-294

Sulindac EP Impurity B

Controlled Product

CAS: 59973-80-7

Formula: C₂₀H₁₇FO₄S

Color and Shape: Neat

Molecular weight: 372.41

Ref: 86-MM0624.02

(Z)-Sulindac Sulfone

CAS: 59973-80-7

Stability Hygroscopic
Applications An active metabolite of Sulindac. Inducer of apoptosis independent of cyclooxygenase inhibition. Inhibits cell growth by inducing apoptosis.
References Piazza, G.A., et al.: Cancer Res., 55, 3310 (1995)

Formula: C₂₀H₁₇FO₄S

Color and Shape: Neat

Molecular weight: 372.41

Ref: TR-S699225

Sulindac Sulfone-d6

Controlled Product

CAS: 59973-80-7

Applications Labelled analogue of Sulindac Sulfone, an active metabolite of Sulindac. Inducer of apoptosis independent of cyclooxygenase inhibition. Inhibits cell growth by inducing apoptosis.
References Piazza, G.A. et al.: Cancer Res., 55, 3310 (1995);

Formula: C₂₀H₁₁D₆FO₄S

Color and Shape: Neat

Molecular weight: 378.45

Ref: TR-S699227

Sulindac sulfone

CAS: 59973-80-7

Sulindac sulfone is a nonsteroidal anti-inflammatory drug that belongs to the class of sulfones. It has been shown to inhibit the mcl-1 protein, which is involved in the mitochondrial apoptosis pathway. Sulindac sulfone inhibits prostaglandin E2 (PGE2) levels and mitochondrial membrane potential in vitro assays. Sulindac sulfone also has inhibitory properties against a number of enzymes including cyclooxygenase-2 (COX-2), lipoxygenases, phospholipases A2, and thromboxane synthase. These properties are responsible for its anti-inflammatory effects. Sulindac sulfone shows minimal toxicity due to its low bioavailability and lack of liver metabolism. This drug has been shown to have anticancer activity as well as an ability to inhibit infectious diseases such as Leishmania major and Helicobacter pylori.

Formula: C₂₀H₁₇FO₄S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 372.41 g/mol

Ref: 3D-FS27971

Sulindac EP Impurity B

CAS: 59973-80-7

Formula: C₂₀H₁₇FO₄S

Molecular weight: 372.41

Ref: ST-EA-CP-S108002

Exisulind

CAS: 59973-80-7

Exisulind (CP248) triggers apoptosis via PKG activation, shows antitumor effects, and inhibits growth in various rodent cancer models.

Formula: C₂₀H₁₇FO₄S

Purity: 97.94%

Color and Shape: Solid

Molecular weight: 372.41

Ref: TM-T24051