CAS 6035-45-6

Leucovorin calcium pentahydrate

Description:

Leucovorin calcium pentahydrate, also known as calcium folinate, is a derivative of folic acid and is primarily used in medical applications, particularly in oncology and to mitigate the side effects of certain chemotherapy agents. It is a white to off-white crystalline powder that is soluble in water, making it suitable for intravenous or intramuscular administration. The substance acts as a form of reduced folate, which can bypass certain metabolic pathways, thereby enhancing the efficacy of drugs like methotrexate while reducing toxicity. Its chemical structure includes a calcium ion, which contributes to its stability and solubility. Leucovorin is often utilized in combination with other medications to treat various types of cancer and to prevent or treat folate deficiency. In addition to its therapeutic uses, it is important to handle this compound with care, following appropriate safety guidelines, as it can interact with other medications and may have contraindications in certain patient populations.

Formula: C₂₀H₃₁CaN₇O₁₂

InChI: InChI=1/C20H23N7O7.Ca.5H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;;;;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;5*1H2/q;+2;;;;;/p-2/t12?,13-;;;;;;/m0....../s1

Synonyms:

• Folinic acid, calcium salt pentahydrate
• Calcium folinate pentahydrate
• calcium (2S)-2-{[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)carbonyl]amino}pentanedioate pentahydrate

Calcium Folinate

CAS: 1492-18-8, 2060570-47-8, 58-05-9, 6035-45-6

Formula: C₂₀H₂₁CaN₇O₇

Purity: >98.0%(T)(HPLC)

Color and Shape: Light orange to Yellow to Green powder to crystaline

Molecular weight: 511.51

Ref: 3B-C2235

Folinic Acid Calcium Pentahydrate

CAS: 6035-45-6

Formula: C₂₀H₃₁CaN₇O₁₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 601.5778

Ref: IN-DA00E8Q2

Folinic Acid Calcium Salt Pentahydrate

CAS: 6035-45-6

Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate), a reduced folic acid, is used in combination with other chemotherapeutics.

Formula: C₂₀H₂₁CaN₇O₇·5H₂O

Purity: 99.17% - >99.99%

Color and Shape: Yellowish-White To Yellow Powder

Molecular weight: 601.58

Ref: TM-T0148L

Folinic Acid Calcium Salt Pentahydrate

CAS: 6035-45-6

Folinic Acid Calcium Salt Pentahydrate

Purity: ≥98%

Molecular weight: 601.58g/mol

Ref: 54-BUP15968

Calcium Folinate Pentahydrate

CAS: 6035-45-6

Calcium Folinate Pentahydrate

Purity: 98%

Molecular weight: 601.58g/mol

Ref: 54-OR1012602

Leucovorin Calcium Salt Pentahydrate

CAS: 6035-45-6

Applications An intermediate product of the metabolism of Folic Acid. This compound is a mixture of diastereomers.
References Pont, L.O., et al.: Anal. Profiles Drug Subs., 8, 315 (1979), Yale, R.J.D, et al.: J. Biol. Med., 61, 23 (1988),

Formula: C₂₀H₃₁CaN₇O₁₂

Color and Shape: Neat

Molecular weight: 601.58

Ref: TR-L330400

Leucovorin-d4 Calcium Salt Hydrate, > 90%

Controlled Product

CAS: 6035-45-6

Applications An labelled intermediate product of the metabolism of Folic Acid. This compound is a mixture of diastereomers.
References Pont, L.O., et al.: Anal. Profiles Drug Subs., 8, 315 (1979), Yale, R.J.D, et al.: J. Biol. Med., 61, 23 (1988),

Formula: C₂₀H₁₇D₄CaN₇O₇•xH₂O

Purity: >90%

Color and Shape: Light Yellow To Yellow

Molecular weight: 515.53

Ref: TR-L330402

Calcium folinate pentahydrate

CAS: 6035-45-6

Calcium folinate pentahydrate is a drug that is used to treat overexertion. It is also used as a pharmacological treatment for cancer and as a drug repositioning agent. Calcium folinate pentahydrate has been shown to be effective in treating the symptoms of overexertion, including muscle cramps, pain, and fatigue. This drug binds to the casein in the bloodstream and forms calcium citrate, which is then excreted from the body. In cancer patients, this drug prevents tumor cells from dividing by inhibiting DNA synthesis and RNA synthesis. It does not affect normal cells because it cannot diffuse through membranes that are impenetrable by ions (e.g., cell membrane).

Formula: C₂₀H₂₁CaN₇O₇·5H₂O

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 601.58 g/mol

Ref: 3D-FC36667

5-(α-Folinilamido) Tetrahydrofolic Acid

Controlled Product

CAS: 6035-45-6

Formula: C₃₉H₄₄N₁₄O₁₂

Color and Shape: Neat

Molecular weight: 900.853

Ref: TR-F680335

Leucovorin Calcium Pentahydrate

CAS: 6035-45-6

Formula: C₂₀H₂₁N₇O₇₂CaH₂O

Molecular weight: 471.43 : 40.08 : 5(36.46)

Ref: ST-EA-CP-L48004