CAS 606143-52-6

Selumetinib

Description:

Selumetinib is a small molecule inhibitor primarily known for its role as a targeted therapy in cancer treatment, particularly for tumors with mutations in the RAS signaling pathway. It specifically inhibits the activity of MEK1 and MEK2, which are key components of the mitogen-activated protein kinase (MAPK) pathway, thereby disrupting cell proliferation and survival signals in cancer cells. Selumetinib is characterized by its ability to selectively target these kinases, leading to reduced tumor growth in certain types of cancers, including non-small cell lung cancer and neurofibromatosis type 1. The compound is typically administered orally and has been studied in various clinical trials to assess its efficacy and safety profile. Its chemical structure includes a sulfonamide group, contributing to its pharmacological properties. As with many targeted therapies, selumetinib may have specific side effects, which can include gastrointestinal disturbances and skin reactions, necessitating careful monitoring during treatment. Overall, selumetinib represents a significant advancement in the field of oncology, particularly for patients with specific genetic tumor profiles.

Formula: C₁₇H₁₅BrClFN₄O₃

InChI: InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChI key: InChIKey=CYOHGALHFOKKQC-UHFFFAOYSA-N

SMILES: N(C1=C(C(NOCCO)=O)C=C2C(=C1F)N=CN2C)C3=C(Cl)C=C(Br)C=C3

Synonyms:

• 1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-
• 5-(4-Bromo-2-chlorophenylamino)-4-fluoro-1-methyl-1H-benzimidazole-6-carbohydroxamic acid 2-hydroxyethyl ester
• 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
• 6-(4-Bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
• Arry-142886
• Azd 6244
• Azd-6224
• Azd6244
• G 00039805
• Koselugo
• NSC 741O78
• Zd-6244
• Selumetinib
• selumetinib (MEK inhibitor)
• 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carbox
• AZD6244(SeluMetinib)
• SeluMatinib(5-[(4-BroMo-2-chlorophenyl)aMino]-4-fluoro-N-(2-hydroxyethoxy)-1-Methyl-1H-benziMidazole-6-carboxaMide
• AZD-6244(SeluMetinib)/AZD6244
• AZD6244, ARRY-142886, ARRY-886
• 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide Selumetinib (AZD6244)
• 5-(4-Bromo-2-chlorophenylamino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide
• Array142886
• 6-(4-Bromo-2-chlorophenylamino)-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-3H-benzo[d]imidazole-5-carboxamide

5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide

CAS: 606143-52-6

Formula: C₁₇H₁₅BrClFN₄O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 457.6814

Ref: IN-DA0037GN

Selumetinib

CAS: 606143-52-6

Selumetinib

Purity: ≥95%

Molecular weight: 457.68g/mol

Ref: 54-BUP13953

Selumetinib

CAS: 606143-52-6

Formula: C₁₇H₁₅BrClFN₄O₃

Molecular weight: 457.68

Ref: 4Z-S-256003

Selumetinib

CAS: 606143-52-6

Selumetinib

Color and Shape: White To Off White Solid

Molecular weight: 457.68g/mol

Ref: 54-BIFK0041

Selumetinib

CAS: 606143-52-6

Ref: 7W-GW9004

Selumetinib

CAS: 606143-52-6

Selumetinib (AZD6244) is a selectivity and non-ATP-competitive MEK1/2 inhibitor. Selumetinib has antitumor activity. Cost-effective and quality-assured.

Formula: C₁₇H₁₅BrClFN₄O₃

Purity: 98.1% - 99.90%

Color and Shape: White Or Pale White Solid

Molecular weight: 457.68

Ref: TM-T6218

Selumetinib

Controlled Product

CAS: 606143-52-6

Applications It is a tight-binding, uncompetitive inhibitor of mitogen-activated protein kinase kinases (MEK) 1 and 2 currently in clinical development. It is useful as biomarker in human lung cancer cell. Potent MEK inhibitor.
References Ciardiello, F., et al.: Clin. Cancer Res., 7, 1459 (2001), Hidalgo, M., et al.: J. Clin. Oncol., 19, 3267 (2001),

Formula: C₁₇H₁₅BrClFN₄O₃

Color and Shape: Neat

Molecular weight: 457.68

Ref: TR-S254000

Selumetinib

CAS: 606143-52-6

Potent and selective MAP/ERK kinase 1/2 inhibitor. Reduces growth of tumor cells with B-Raf and Ras mutations. Tumor regression observed after chronic treatment in in vivo xenograft models. Enhances anti-tumor effect in combination with irinotecan or docetaxel.

Formula: C₁₇H₁₅BrClFN₄O₃

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 457.68 g/mol

Ref: 3D-FS27812

5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide

CAS: 606143-52-6

Formula: C₁₇H₁₅BrClFN₄O₃

Purity: 95%

Molecular weight: 457.68

Ref: 10-F361876