CAS 606143-52-6: Selumetinib

Description: Selumetinib is a small molecule inhibitor primarily known for its role as a targeted therapy in cancer treatment, particularly for tumors with mutations in the RAS signaling pathway. It specifically inhibits the activity of MEK1 and MEK2, which are key components of the mitogen-activated protein kinase (MAPK) pathway, thereby disrupting cell proliferation and survival signals in cancer cells. Selumetinib is characterized by its ability to selectively target these kinases, leading to reduced tumor growth in certain types of cancers, including non-small cell lung cancer and neurofibromatosis type 1. The compound is typically administered orally and has been studied in various clinical trials to assess its efficacy and safety profile. Its chemical structure includes a sulfonamide group, contributing to its pharmacological properties. As with many targeted therapies, selumetinib may have specific side effects, which can include gastrointestinal disturbances and skin reactions, necessitating careful monitoring during treatment. Overall, selumetinib represents a significant advancement in the field of oncology, particularly for patients with specific genetic tumor profiles.

Formula: C₁₇H₁₅BrClFN₄O₃

InChI: InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChI key: InChIKey=CYOHGALHFOKKQC-UHFFFAOYSA-N

SMILES: O=C(NOCCO)C1=CC2=C(N=CN2C)C(F)=C1NC3=CC=C(Br)C=C3Cl

Synonyms:

• 1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-
• 5-(4-Bromo-2-chlorophenylamino)-4-fluoro-1-methyl-1H-benzimidazole-6-carbohydroxamic acid 2-hydroxyethyl ester
• 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
• 6-(4-Bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
• Arry-142886
• Azd 6244
• Azd-6224
• Azd6244
• G 00039805
• Koselugo
• NSC 741O78
• Zd-6244
• Selumetinib

5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide

CAS: 606143-52-6

• Formula: C₁₇H₁₅BrClFN₄O₃
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 457.6814

Selumetinib

CAS: 606143-52-6

• Purity: 99.46%
• Molecular weight: 457.68g/mol

Selumetinib

CAS: 606143-52-6

• Color and Shape: White To Off White Solid
• Molecular weight: 457.68g/mol

Selumetinib

CAS: 606143-52-6

Selumetinib (AZD6244) is a selectivity and non-ATP-competitive MEK1/2 inhibitor. Selumetinib has antitumor activity. Cost-effective and …

• Formula: C₁₇H₁₅BrClFN₄O₃
• Purity: 98.1% - 99.46%
• Color and Shape: White Or Pale White Solid
• Molecular weight: 457.68

Selumetinib

CAS: 606143-52-6

Selumetinib

CAS: 606143-52-6

Applications It is a tight-binding, uncompetitive inhibitor of mitogen-activated protein kinase kinases (MEK) 1 and …

• Formula: C₁₇H₁₅BrClFN₄O₃
• Color and Shape: Neat
• Molecular weight: 457.68

Selumetinib

CAS: 606143-52-6

Potent and selective MAP/ERK kinase 1/2 inhibitor. Reduces growth of tumor cells with B-Raf and …

• Formula: C₁₇H₁₅BrClFN₄O₃
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 457.68 g/mol