Selumetinib

CAS: 606143-52-6

Ref. 3D-FS27812

Product Information

• Name: Selumetinib
• Synonyms: 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, 1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-, 5-(4-Bromo-2-chlorophenylamino)-4-fluoro-1-methyl-1H-benzimidazole-6-carbohydroxamic acid 2-hydroxyethyl ester, 6-(4-Bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide, Arry-142886, Azd 6244, Azd-6224, Azd6244, G 00039805, Koselugo, NSC 741O78, Zd-6244
• CAS: 606143-52-6

Description

Potent and selective MAP/ERK kinase 1/2 inhibitor. Reduces growth of tumor cells with B-Raf and Ras mutations. Tumor regression observed after chronic treatment in in vivo xenograft models. Enhances anti-tumor effect in combination with irinotecan or docetaxel.

• Brand: Biosynth

Chemical properties

• Molecular weight: 457.68 g/mol
• Formula: C₁₇H₁₅BrClFN₄O₃
• Purity: Min. 98 Area-%
• Color/Form: White Powder
• InChI: InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
• InChI key: InChIKey=CYOHGALHFOKKQC-UHFFFAOYSA-N
• SMILES: Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(C(=O)NOCCO)cc21