CAS 606143-89-9: ARRY 438162

Description: ARRY 438162, with the CAS number 606143-89-9, is a chemical compound that belongs to the class of small molecule inhibitors. It is primarily recognized for its role as a selective inhibitor of certain kinases, particularly those involved in cancer signaling pathways. The compound exhibits properties that make it a candidate for therapeutic applications, particularly in oncology, by targeting specific molecular mechanisms that drive tumor growth and proliferation. Its structure typically includes functional groups that enhance its binding affinity to target proteins, contributing to its efficacy. Additionally, ARRY 438162 has undergone various preclinical and clinical evaluations to assess its pharmacokinetics, safety profile, and potential side effects. As with many investigational compounds, its characteristics, including solubility, stability, and metabolic pathways, are crucial for understanding its behavior in biological systems and its potential for development into a therapeutic agent.

Formula: C₁₇H₁₅BrF₂N₄O₃

InChI: InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChI key: InChIKey=ACWZRVQXLIRSDF-UHFFFAOYSA-N

SMILES: O=C(NOCCO)C1=CC2=C(N=CN2C)C(F)=C1NC3=CC=C(Br)C=C3F

Synonyms:

• 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
• Arry 162
• Arry 438162
• Binimetinib
• Mek 162
• Mektovi
• 1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-

5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide

CAS: 606143-89-9

• Formula: C₁₇H₁₅BrF₂N₄O₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 441.2268

Binimetinib (MEK-162)

CAS: 606143-89-9

• Formula: C₁₇H₁₅BrF₂N₄O₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 441.23

MEK162

CAS: 606143-89-9

• Formula: C₁₇H₁₅BrF₂N₄O₃
• Purity: 99.55% (lcms) (Typical Value in Batch COA)
• Color and Shape: white to off-white solid
• Molecular weight: 441.23g/mol

Binimetinib

CAS: 606143-89-9

• Purity: 98.02%
• Molecular weight: 441.23g/mol

MEK 162

CAS: 606143-89-9

• Formula: C₁₇H₁₅BrF₂N₄O₃
• Purity: >95.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 441.23

Binimetinib

CAS: 606143-89-9

Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has …

• Formula: C₁₇H₁₅BrF₂N₄O₃
• Purity: 100% - 99%
• Color and Shape: Solid
• Molecular weight: 441.23

MEK 162

CAS: 606143-89-9

Applications MEK 162 is a MEK1/2 inhibitor allowing it to be a effective anti-cancer medication. …

• Formula: C₁₇H₁₅BrF₂N₄O₃
• Color and Shape: Neat
• Molecular weight: 441.23

MEK162

CAS: 606143-89-9

Inhibitor of MEK1/2 kinase enzymes; antineoplastic

• Formula: C₁₇H₁₅BrF₂N₄O₃
• Purity: Min. 95%
• Color and Shape: White/Off-White Solid
• Molecular weight: 441.23 g/mol

MEK 162-13C, 15N3

CAS: 606143-89-9

Applications MEK 162-13C, 15N3 is the labeled analogue of MEK 162 (M208300), a MEK1/2 inhibitor.

• Formula: C₁₆CH₁₅BrF₂NN₃O₃
• Color and Shape: Neat
• Molecular weight: 445.2

MEK 162-13CD3

CAS: 606143-89-9

• Formula: CC₁₆D₃H₁₂BrF₂N₄O₃
• Color and Shape: Neat
• Molecular weight: 445.238

N-Desmethyl Binimetinib

CAS: 606143-89-9

• Formula: C₁₆H₁₃BrF₂N₄O₃
• Color and Shape: Neat
• Molecular weight: 427.2