CAS 606143-89-9

ARRY 438162

Description:

ARRY 438162, with the CAS number 606143-89-9, is a chemical compound that belongs to the class of small molecule inhibitors. It is primarily recognized for its role as a selective inhibitor of certain kinases, particularly those involved in cancer signaling pathways. The compound exhibits properties that make it a candidate for therapeutic applications, particularly in oncology, by targeting specific molecular mechanisms that drive tumor growth and proliferation. Its structure typically includes functional groups that enhance its binding affinity to target proteins, contributing to its efficacy. Additionally, ARRY 438162 has undergone various preclinical and clinical evaluations to assess its pharmacokinetics, safety profile, and potential side effects. As with many investigational compounds, its characteristics, including solubility, stability, and metabolic pathways, are crucial for understanding its behavior in biological systems and its potential for development into a therapeutic agent.

Formula: C₁₇H₁₅BrF₂N₄O₃

InChI: InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChI key: InChIKey=ACWZRVQXLIRSDF-UHFFFAOYSA-N

SMILES: N(C1=C(C(NOCCO)=O)C=C2C(=C1F)N=CN2C)C3=C(F)C=C(Br)C=C3

Synonyms:

• 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
• Arry 162
• Arry 438162
• Binimetinib
• Mek 162
• Mektovi
• 1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-
• Binimetinib (MEK-162)
• 1H-Benzimidazole-6-carboxamide,5-[(4-bromo-2-fluorophenyl)am...
• 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-car
• BINIMETINIB, ARRY-438162
• MEK162, ARRY-162
• Binimetinib ( Mektovi
• 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide
• MEK162
• MEK162 (ARRY-438162)
• Binimetinib USP/EP/BP
• Binimetinib,MEK162, ARRY-162
• BiniMetinib (MEK162, ARRY-162, ARRY-438162)
• Binimetinib(Free Base)
• MEK162(Binimetinib)
• 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methylbenzimidazole-6-carboxamide
• MEK162 (ARRY-162, ARRY-438162)
• MEK162 (ARRY-438162,Binimetinib)
• 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide Binimetinib (MEK162, ARRY-162, ARRY-438162)
• ARRY 162; ARRY 438162; MEK-162;BINIMETINIB;MEK-162; ARRY-162; ARRY-438162

5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide

CAS: 606143-89-9

Formula: C₁₇H₁₅BrF₂N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 441.2268

Ref: IN-DA0039DV

Binimetinib (MEK-162)

CAS: 606143-89-9

Formula: C₁₇H₁₅BrF₂N₄O₃

Color and Shape: White To Off-White Solid

Molecular weight: 441.23

Ref: 4Z-B-207001

MEK162

CAS: 606143-89-9

MEK162

Formula: C₁₇H₁₅BrF₂N₄O₃

Purity: 99.55% (lcms) (Typical Value in Batch COA)

Color and Shape: white to off-white solid

Molecular weight: 441.23g/mol

Ref: 54-BISN0213

Binimetinib

CAS: 606143-89-9

Binimetinib

Purity: ≥98%

Molecular weight: 441.23g/mol

Ref: 54-BUP13373

MEK 162

CAS: 606143-89-9

Formula: C₁₇H₁₅BrF₂N₄O₃

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 441.23

Ref: 3B-B6728

Binimetinib

CAS: 606143-89-9

Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.

Formula: C₁₇H₁₅BrF₂N₄O₃

Purity: 98.03% - >99.99%

Color and Shape: Solid

Molecular weight: 441.23

Ref: TM-T2508

MEK 162

Controlled Product

CAS: 606143-89-9

Applications MEK 162 is a MEK1/2 inhibitor allowing it to be a effective anti-cancer medication.
References Kopetz,S., et al.: N. Engl., 381, 1632-1643

Formula: C₁₇H₁₅BrF₂N₄O₃

Color and Shape: Neat

Molecular weight: 441.23

Ref: TR-M208300

MEK162

CAS: 606143-89-9

Inhibitor of MEK1/2 kinase enzymes; antineoplastic

Formula: C₁₇H₁₅BrF₂N₄O₃

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 441.23 g/mol

Ref: 3D-FM65077

Binimetinib

CAS: 606143-89-9

Purity: 98%

Molecular weight: 441.233

Ref: 10-F979736

MEK 162-13CD3

Controlled Product

CAS: 606143-89-9

Formula: CC₁₆D₃H₁₂BrF₂N₄O₃

Color and Shape: Neat

Molecular weight: 445.238

Ref: TR-M208303

MEK 162-13C, 15N3

Controlled Product

CAS: 606143-89-9

Applications MEK 162-13C, 15N3 is the labeled analogue of MEK 162 (M208300), a MEK1/2 inhibitor.

Formula: C₁₆CH₁₅BrF₂NN₃O₃

Color and Shape: Neat

Molecular weight: 445.2

Ref: TR-M208302

N-Desmethyl Binimetinib

Controlled Product

CAS: 606143-89-9

Formula: C₁₆H₁₃BrF₂N₄O₃

Color and Shape: Neat

Molecular weight: 427.2

Ref: TR-D427820