CAS 6066-82-6

N-Hydroxysuccinimide

Description:

N-Hydroxysuccinimide (NHS) is a chemical compound widely used in biochemistry and organic synthesis, particularly for its role in coupling reactions. It is a white to off-white crystalline solid that is soluble in polar solvents such as water and dimethyl sulfoxide (DMSO). NHS is known for its ability to form stable amide bonds with primary amines, making it a valuable reagent for the modification of biomolecules, including proteins and peptides. The compound is often used in the preparation of NHS esters, which are reactive intermediates that facilitate the conjugation of various molecules. Its structure features a succinimide ring with a hydroxyl group, contributing to its reactivity. Additionally, NHS is relatively stable under standard laboratory conditions but should be handled with care, as it can be sensitive to moisture and heat. Overall, N-Hydroxysuccinimide is an essential tool in chemical biology and pharmaceutical research, enabling the development of targeted therapies and diagnostic agents.

Formula: C₄H₅NO₃

InChI: InChI=1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2

InChI key: InChIKey=NQTADLQHYWFPDB-UHFFFAOYSA-N

SMILES: ON1C(=O)CCC1=O

Synonyms:

• 1-Hydroxy-2,5-pyrrolidinedione
• 1-Hydroxysuccinimide
• Hydroxysuccinimide
• N-Hydroxy-2,5-dioxopyrrolidine
• N-Hydroxypyrrolidine-2,5-dione
• N-Hydroxysuccinimid
• N-Hydroxysuccinimide
• N-hidroxisuccinimida
• Nsc 74335
• Succinimide, N-Hydroxy-
• HONSU
• NHS
• N-HYDROXYSUCCINIMDE
• HOSu
• 5-Pyrrolidinedione,1-hydroxy-2
• 1-Hydroxy-2,5-pyrrolidine-dione
• 2,5-Pyrrolidinedione, 1-hydroxy-
• N-HYDROXY-2,5-PYRROLIDINEDIONE
• N-Hydroxysuccinimide POLYMER-BOUND
• 1-hydroxypyrrolidine-2,5-dione

N-Hydroxysuccinimide [Coupling Reagent for Peptide]

CAS: 6066-82-6

Formula: C₄H₅NO₃

Purity: >98.0%(GC)(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 115.09

Ref: 3B-B0249

N-Hydroxysuccinimide

CAS: 6066-82-6

Formula: C₄H₅NO₃

Purity: >98.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 115.09

Ref: 3B-H0623

N-Hydroxysuccinimide, 98+%

CAS: 6066-82-6

N-Hydroxysuccinimide is used for improved amidations in the carbodiimide method. It is also used to activate a carboxyl group and reacts with amine to form amide. It is involved in the preparation of N-hydroxymaleimide-styrene copolymer. Further, it finds use in analytical chemistry. As an additive,

Formula: C₄H₅NO₃

Purity: 98+%

Color and Shape: Crystals or powder or crystalline powder or fused solid, White

Molecular weight: 115.09

Ref: 02-A10312

N-Hydroxysuccinimide

CAS: 6066-82-6

Educt for the synthesis of N-hydroxysuccinimide esters of N-protected amino acids and peptides. Additive for peptide synthesis by the azide fragment condensation on a soluble polymer support. Chiral stabilizer for peptide coupling reactions.

Formula: C₄H₅NO₃

Purity: > 99%

Color and Shape: White

Molecular weight: 115.09

Ref: 01-4025878

N-Hydroxysuccinimide

CAS: 6066-82-6

N-Hydroxysuccinimide

Formula: C₄H₅NO₃

Purity: >97%

Color and Shape: White Solid-Powder

Molecular weight: 115.0874

Ref: 54-BIH6094

N-Hydroxysuccinimide

CAS: 6066-82-6

Formula: C₄H₅NO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 115.0874

Ref: IN-DA0035DX

N-Hydroxysuccinimide

CAS: 6066-82-6

Formula: C₄H₅NO₃

Color and Shape: White To Off-White Solid

Molecular weight: 115.09

Ref: 4Z-S-131002

N-Hydroxysuccinimide

CAS: 6066-82-6

N-Hydroxysuccinimide (NHS) is an activating ester in peptide chemistry and protein cross-linking, a key activating agent in bio-conjugate reactions.

Formula: C₄H₅NO₃

Purity: 99.68% - 99.93%

Molecular weight: 115.0874

Ref: TM-T87003

N-Hydroxysuccinimide

CAS: 6066-82-6

N-Hydroxysuccinimide

Formula: C₄H₅NO₃

Purity: 98%

Color and Shape: White Solid-Powder

Molecular weight: 115.08739

Ref: 54-OR28434

N-Hydroxysuccinimide

CAS: 6066-82-6

Formula: C₄H₅NO₃

Color and Shape: Neat

Molecular weight: 115.09

Ref: TR-H953585

N-Hydroxysuccinimide

CAS: 6066-82-6

Formula: C₄H₅NO₃

Purity: (Titration) ≥ 98.0%

Color and Shape: White to almost white crystalline powder

Molecular weight: 115.09

Ref: 7W-GE3858

NHS

CAS: 6066-82-6

1-Hydroxypyrrolidine-2,5-dione

Formula: C₄H₅NO₃

Purity: 98%

Molecular weight: 115.09

Ref: IN-DG40412

N-Hydroxysuccinimide

CAS: 6066-82-6

An additive in carbodiimide peptide coupling

Formula: C₄H₅NO₃

Color and Shape: White Powder

Molecular weight: 115.09 g/mol

Ref: 3D-FH02165

N-Hydroxysuccinimide

CAS: 6066-82-6

Formula: C₄H₅NO₃

Color and Shape: White odorless solid; [GE Healthcare MSDS]

Molecular weight: 115.09

Ref: BE-RMCS184001

N-Hydroxysuccinimide

CAS: 6066-82-6

Formula: C₄H₅NO₃

Purity: 98.0%

Color and Shape: Solid

Molecular weight: 115.088

Ref: 10-F005022

N-Hydroxysuccinimide pure, 97%

CAS: 6066-82-6

Formula: C₄H₅NO₃

Purity: min. 97.0%

Color and Shape: White to off white, Crystalline hygroscopic powder, Clear, Colourless to pale yellow

Molecular weight: 115.09

Ref: SR-47913

N-Hydroxysuccinimide-d4

Controlled Product

CAS: 6066-82-6

Formula: C₄D₄HNO₃

Color and Shape: Neat

Molecular weight: 119.112

Ref: TR-H953587