CAS 6112-76-1

6-Mercaptopurine monohydrate

Description:

6-Mercaptopurine monohydrate is a purine analog and an antimetabolite used primarily in the treatment of certain types of leukemia and autoimmune diseases. It is characterized by its chemical formula C5H6N4S·H2O, indicating the presence of a mercapto group (-SH) that contributes to its reactivity and biological activity. The substance appears as a white to off-white crystalline powder and is soluble in water, which facilitates its administration in clinical settings. Its mechanism of action involves the inhibition of purine nucleotide synthesis, thereby interfering with DNA and RNA synthesis, which is crucial for rapidly dividing cells. 6-Mercaptopurine is often administered in conjunction with other medications to enhance therapeutic efficacy and reduce the risk of resistance. Due to its potential for toxicity, careful monitoring of blood counts and liver function is essential during treatment. Additionally, it is important to consider genetic factors, such as variations in the TPMT enzyme, which can affect individual responses to the drug.

Formula: C₅H₄N₄S·H₂O

InChI: InChI=1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2

InChI key: InChIKey=WFFQYWAAEWLHJC-UHFFFAOYSA-N

SMILES: S=C1C2=C(NC=N1)N=CN2.O

Synonyms:

• 1,4,5,7-Tetrahydro-6H-Purine-6-Thione Hydrate
• 1,7-Dihydro-6H-Purin-6-Thion,Monohydrat
• 1,7-Dihydro-6H-Purine-6-Thionemonohydrate
• 1,7-Dihydro-6H-Purine-6-Thionmonohydrate
• 3,7-Dihydro-6H-Purine-6-Thione Hydrate
• 6-Mercapto Purine
• 6-Mercaptopurine Hydrate
• 6-Merkaptopurin,Monohydrat
• 6-Purinethiol Monohydrate
• 6-Thiohypoxanthine Monohydrate
• 6H-Purin-6-Thion,Monohydrat
• 6H-Purine-6-thione, 1,2,3,9-tetrahydro-, hydrate (1:1)
• 6H-Purine-6-thione, 1,7-dihydro-, monohydrate
• 7H-Purine-6-Thiolate
• 9H-Purine-6-thiol hydrate
• Leukerin Monohydrate
• Mercaleukin Monohydrate
• Mercaptopurine Monohydrate, 6-Mercaptopurine
• Mercaptopurine, Monohydrate
• Purin-6-Thiol,Monohydrat
• Purine-6-Thiol, Monohydrate
• Xaluprine
• 6-Mercaptopurine monohydrate

6-Mercaptopurine Monohydrate

CAS: 50-44-2, 6112-76-1

Formula: C₅H₄N₄S·H₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: Light yellow to Yellow powder to crystal

Molecular weight: 170.20

Ref: 3B-M0063

6-Mercaptopurine monohydrate, 98%

CAS: 6112-76-1

6-Mercaptopurine is a widely used antileukemic agent that inhibits de novopurine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. It is also an antitumor agent and induces apoptosis. This Thermo Scientific Chemicals brand product was originally part of th

Formula: C₅H₆N₄OS

Purity: 98%

Color and Shape: Yellow, Powder

Molecular weight: 170.19

Ref: 02-A12197

Mercaptopurine

CAS: 6112-76-1

Mercaptopurine

Formula: C₅H₄N₄SH₂O

Purity: 100.3%

Color and Shape: Yellow

Molecular weight: 170.02623

Ref: 47-773

MERCAPTOPURINE MONOHYDRATE CRS

CAS: 6112-76-1

MERCAPTOPURINE MONOHYDRATE CRS

Ref: 41-Y0002452

Mercaptopurine impurity standard

CAS: 154-42-7, 6112-76-1, 68-94-0, 73-24-5

Mercaptopurine impurity standard

Color and Shape: Yellow

Ref: 47-762

Mercaptopurine

CAS: 6112-76-1

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₅H₄N₄S·H₂O

Color and Shape: Yellow Crystalline Powder

Molecular weight: 152.01567

Ref: 45-1392002

6-Mercaptopurine monohydrate

CAS: 6112-76-1

Formula: C₅H₆N₄OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 170.1923

Ref: IN-DA003N94

6-Mercaptopurine hydrate

CAS: 6112-76-1

6-Mercaptopurine hydrate

Purity: ≥95%

Molecular weight: 170.19g/mol

Ref: 54-BUP15972

6-Mercaptopurine monohydrate

CAS: 6112-76-1

Formula: C₅H₄N₄SH₂O

Molecular weight: 170.19

Ref: 7W-GE6799

6-Mercaptopurine-13C-15N2 (Azathioprine EP Impurity B-13C-15N2)

CAS: 207729-57-5, 50-44-2, 6112-76-1

Formula: C₄₁₃CH₄N₂₁₅N₂S

Molecular weight: 155.15

Ref: 4Z-M-834

Mercaptopurine Monohydrate

CAS: 6112-76-1

Color and Shape: Neat

Ref: 86-MM1537.00

6-Mercaptopurine monohydrate

CAS: 6112-76-1

Formula: C5H4N4S.H2O

Color and Shape: Light yellow powder

Molecular weight: 170.1923

Ref: 3T-12652909

6-Mercaptopurine monohydrate

CAS: 6112-76-1

6-Mercaptopurine monohydrate

Formula: C₅H₄N₄S·H₂O

Purity: By hplc: 98.7% (Typical Value in Batch COA)

Color and Shape: yellow powder

Molecular weight: 170.19g/mol

Ref: 54-BIM0129

6-Mercaptopurine hydrate

CAS: 6112-76-1

6-Mercaptopurine hydrate is a leukemia treatment; it blocks purine metabolism, affecting DNA synthesis.

Formula: C₅H₆N₄OS

Purity: 97.54% - 99.14%

Color and Shape: Light Yellow Crystalline Powder

Molecular weight: 170.19

Ref: TM-T2201

6-Mercaptopurine Monohydrate (Azathioprine EP Impurity B Monohydrate)

CAS: 6112-76-1

Formula: C₅H₄N₄S·H₂O

Molecular weight: 152.18 18.02

Ref: 4Z-M-833

6-Mercaptopurine Monohydrate

Controlled Product

CAS: 6112-76-1

Applications An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zeng, H., et al.: Biochem. Pharmacol., 68, 911 (2004),

Formula: C₅H₄N₄S·H₂O

Color and Shape: Yellow

Molecular weight: 170.19

Ref: TR-M225450

6-Mercaptopurine hydrate

CAS: 6112-76-1

6-Mercaptopurine is a purine analog that suppresses the production of white blood cells by inhibiting the enzyme thiopurine methyltransferase. It has been used to treat bowel disease and also for long-term suppression of the immune system in patients with autoimmune diseases. 6-Mercaptopurine is metabolized to 6-mercaptopurine, which is then converted to dinucleotide phosphate (dNTP) by group P2 enzymes. This conversion allows 6-mercaptopurine to inhibit dNTP synthesis and cell division. The effects of 6-mercaptopurine are potentiated when given in conjunction with azathioprine, another drug that inhibits purine metabolism. 6-Mercaptopurine is not active against human serum albumin or erythrocytes because it cannot be cleaved into an active form by these proteins. However, it does inhibit enzyme activities such as DNA polymerase, RNA polymerase, and protein

Formula: C₅H₄N₄S•H₂O

Purity: Min. 97 Area-%

Color and Shape: Yellow Powder

Molecular weight: 152.18 g/mol

Ref: 3D-FM08197

6-Mercaptopurine Monohydrate extrapure, 99%

CAS: 6112-76-1

Formula: C₅H₄N₄S·H₂O

Purity: min. 99%

Color and Shape: Yellow, Crystalline powder

Molecular weight: 170.19

Ref: SR-18382

6-Mercaptopurine monohydrate

CAS: 6112-76-1

Formula: C₅H₆N₄OS

Purity: 98.0%

Color and Shape: Solid

Molecular weight: 170.19

Ref: 10-F358394

Mercaptopurine impurity standard

CAS: 6112-76-1

Mercaptopurine impurity standard is a drug product that is used as an analytical reference standard in the development of drugs. Mercaptopurine impurity standard is a natural metabolite of 6-mercaptopurine, which is used to treat leukemia and other forms of cancer. It has been shown to have an anti-inflammatory effect, but this has not been confirmed. Mercaptopurine impurity standard is a synthetic compound that is made synthetically for use as an impurity standard. It has also been shown to be metabolized by cytochrome P450 enzymes, glutathione reductase, or conjugation with glucuronic acid. Mercaptopurine impurity standard has been shown to be stable under acidic conditions and heat treatment at temperatures up to 200°C.

Purity: Min. 95%

Ref: 3D-IM63780