CAS 6119-47-7

Quinine hydrochloride dihydrate

Description:

Quinine hydrochloride dihydrate is a chemical compound derived from the bark of the cinchona tree, primarily known for its use as an antimalarial agent. It is a white to off-white crystalline powder that is soluble in water, which facilitates its use in various pharmaceutical formulations. The compound has a bitter taste, characteristic of quinine, and is often used in tonic water and other beverages for flavoring. Quinine hydrochloride dihydrate has a molecular formula that includes both quinine and hydrochloric acid, along with two water molecules, contributing to its dihydrate classification. In addition to its antimalarial properties, it has been studied for its potential analgesic and anti-inflammatory effects. The compound acts by interfering with the parasite's ability to metabolize and utilize hemoglobin, ultimately leading to its death. Safety and dosage considerations are crucial, as excessive intake can lead to side effects such as cinchonism, characterized by symptoms like tinnitus and nausea. Overall, quinine hydrochloride dihydrate remains an important compound in both medicinal and culinary contexts.

Formula: C₂₀H₂₄N₂O₂·ClH·2H₂O

InChI: InChI=1S/C20H24N2O2.ClH.2H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;2*1H2/t13-,14-,19-,20+;;;/m0.../s1

InChI key: InChIKey=MPQKYZPYCSTMEI-FLZPLBAKSA-N

SMILES: [C@@H](O)(C=1C2=C(C=CC(OC)=C2)N=CC1)[C@]3([N@@]4C[C@H](C=C)[C@](C3)(CC4)[H])[H].Cl.O

Synonyms:

• (4beta,8alpha,9R)-6'-methoxycinchonan-9-ol hydrochloride dihydrate
• (9R)-6'-methoxycinchonan-1'-ium-9-ol chloride dihydrate
• (R)(6-Methoxy-4-quinolyl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol hydrochloride
• Cinchonan-9-ol, 6′-methoxy-, hydrochloride, hydrate (1:1:2), (8α,9R)-
• Cinchonan-9-ol, 6′-methoxy-, monohydrochloride, dihydrate, (8α,9R)-
• Quinine Hydrochloride Dihydrate

Quinine Hydrochloride Dihydrate

CAS: 6119-47-7

Formula: C₂₀H₂₄N₂O₂·HCl·2H₂O

Purity: >98.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 396.91

Ref: 3B-Q0030

Quinine monohydrochloride dihydrate, 99% (total base), may contain up to 10% Dihydroquinine

CAS: 6119-47-7

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to t

Formula: C₂₀H₂₉ClN₂O₄

Purity: 99%

Color and Shape: Powder or crystalline powder or needles, White to pale cream

Molecular weight: 396.91

Ref: 02-H33474

Quinine.HCl.dihydrate, 1mg/ml in Ethanol (as free base)

CAS: 6119-47-7

Color and Shape: Colourless

Ref: LP-QUN-1135-HC-1LE

Quinine.HCl.dihydrate

CAS: 6119-47-7

Color and Shape: White

Ref: LP-QUN-1135-HC-10

Quinine Hydrochloride Dihydrate

CAS: 6119-47-7

Quinine and its salts

Formula: C₂₀H₂₄N₂O₂·HCl·2H₂O

Color and Shape: Colorless Needles

Molecular weight: 396.18159

Ref: 45-1596807

Quinine hydrochloride dihydrate

CAS: 6119-47-7

Formula: C₂₀H₂₄N₂O₂·HCl·2H₂O

Purity: 99.0 - 101.0 %

Color and Shape: White or almost white crystalline powder

Molecular weight: 396.91

Ref: 7W-GA8217

Quinine monohydrochloride dihydrate

CAS: 6119-47-7

Quinine monohydrochloride dihydrate

Formula: C₂₀H₂₄N₂O₂·ClH·2H₂O

Purity: By hplc: 99.6% by area (Typical Value in Batch COA)

Color and Shape: white crystalline powder

Molecular weight: 396.91g/mol

Ref: 54-BIQ1204

Quinine hydrochloride dihydrate, 10mM (in DMSO)

CAS: 6119-47-7

Quinine hydrochloride dihydrate, 10mM (in DMSO)

Purity: ≥98%

Molecular weight: 396.91g/mol

Ref: 54-BUP19126

Quinine Hydrochloride Dihydrate

Controlled Product

CAS: 6119-47-7

Formula: C₂₀H₂₄N₂O₂·ClHH₂O

Color and Shape: Neat

Molecular weight: 396.91

Ref: 86-MM1736.00

Quinine hydrochloride dihydrate

CAS: 6119-47-7

Formula: C₂₀H₂₉ClN₂O₄

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 396.91

Ref: 10-F222360

Quinine hydrochloride dihydrate

CAS: 6119-47-7

Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria.

Formula: C₂₀H₂₄N₂O₂·HCl·2H₂O

Purity: 99.91%

Color and Shape: White To Light Yellow Crystal Powder

Molecular weight: 396.91

Ref: TM-T6631

Quinidine Hydrochloride Dihydrate

Controlled Product

CAS: 6119-47-7

Applications Quinidine Hydrochloride Dihydrate is a salt of Quinidine (Q685000), a dextrorotatory stereoisomer of Quinine. Antiarrhythmic (class IA). Antimalarial.
References Loutfy, M.A., et al.: Anal. Profiles Drug Subs., 12, 483 (1983), Mason, J. W., et al.: Ann. N. Y. Acad. Sci., 432, 162 (1984),

Formula: C₂₀H₂₄N₂O₂·ClH·2H₂O

Color and Shape: White

Molecular weight: 396.91

Ref: TR-Q685045

Quinine hydrochloride dihydrate

CAS: 6119-47-7

Quinine hydrochloride dihydrate is a natural compound that has been used for centuries as a treatment for malaria. It is an effective anti-malarial agent and is also used to treat nocturnal leg cramps, although it has a low potency. Quinine hydrochloride dihydrate is active against the parasite Plasmodium falciparum in vitro. It binds to hemozoin, which is the pigment that the malaria parasites produce during digestion of hemoglobin from red blood cells. This binding inhibits the growth of the parasite and causes cell death by inhibiting protein synthesis. Quinine hydrochloride dihydrate has been shown to be genotoxic in vivo, but not in vitro. The genotoxic effects may be due to its ability to create reactive oxygen species (ROS) through photochemical reactions with light exposure and other chemical reactions, such as thermal expansion or matrix effects.

Formula: C₂₀H₂₄N₂O₂·HCl·2H₂O

Color and Shape: Powder

Molecular weight: 396.91 g/mol

Ref: 3D-FQ43018