CAS 61380-41-4

Lofentanil oxalate

Description:

Lofentanil oxalate is a synthetic opioid analgesic that is structurally related to fentanyl, designed for use in pain management. It is characterized by its high potency, which is significantly greater than that of morphine, making it effective in treating severe pain. Lofentanil oxalate acts primarily on the mu-opioid receptors in the central nervous system, leading to analgesic effects, sedation, and potential respiratory depression. The substance is typically administered in a controlled medical setting due to its potency and the risk of overdose. Its pharmacokinetics involve rapid absorption and distribution, with a relatively short half-life, necessitating careful dosing and monitoring. As with other opioids, lofentanil oxalate carries a risk of dependence and abuse, and its use is regulated in many jurisdictions. Safety measures and guidelines are essential to mitigate potential adverse effects, including respiratory depression and sedation, particularly in vulnerable populations. Overall, lofentanil oxalate represents a powerful tool in pain management, albeit with significant risks that require careful oversight.

Formula: C₂₅H₃₂N₂O₃·C₂H₂O₄

InChI: InChI=1/C25H32N2O3.C2H2O4/c1-4-23(28)27(22-13-9-6-10-14-22)25(24(29)30-3)16-18-26(19-20(25)2)17-15-21-11-7-5-8-12-21;3-1(4)2(5)6/h5-14,20H,4,15-19H2,1-3H3;(H,3,4)(H,5,6)/t20-,25+;/s2

InChI key: InChIKey=CBKLICUQYUTWQL-NBMJJICSNA-N

SMILES: N(C(CC)=O)([C@@]1(C(OC)=O)[C@@H](C)CN(CCC2=CC=CC=C2)CC1)C3=CC=CC=C3.C(C(O)=O)(O)=O

Synonyms:

• 4-Piperidinecarboxylic acid, 3-methyl-4-[(1-oxopropyl)phenylamino]-1-(2-phenylethyl)-, methyl ester, (3R,4S)-rel-(-)-, ethanedioate (1:1)
• 4-Piperidinecarboxylic acid, 3-methyl-4-[(1-oxopropyl)phenylamino]-1-(2-phenylethyl)-, methyl ester, cis-(-)-, ethanedioate (1:1)
• R 34995
• Lofentanil oxalate

Lofentanil Oxalate

Controlled Product

CAS: 61380-41-4

Formula: C₂₇H₃₄N₂O₇

Color and Shape: Neat

Molecular weight: 498.57

Ref: TR-L469370

Lofentanil Oxalate (1 mg/ml in Acetonitrile)

Controlled Product

CAS: 61380-41-4

Formula: C₂₇H₃₄N₂O₇

Color and Shape: Single Solution

Molecular weight: 498.57

Ref: TR-KIT5505