CAS 61413-54-5: Rolipram

Description: Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor, primarily known for its potential therapeutic effects in treating conditions such as depression and inflammatory diseases. It is a white to off-white crystalline powder that is soluble in organic solvents like dimethyl sulfoxide (DMSO) and ethanol but has limited solubility in water. Rolipram's mechanism of action involves the inhibition of PDE4, which leads to increased levels of cyclic adenosine monophosphate (cAMP) in cells, thereby enhancing signaling pathways that can improve mood and reduce inflammation. The compound has a relatively low molecular weight and exhibits moderate lipophilicity, which influences its pharmacokinetic properties. Rolipram has been studied extensively in preclinical and clinical settings, although its use has been limited due to side effects associated with PDE4 inhibition. Overall, Rolipram represents an important compound in the field of medicinal chemistry, particularly in the context of neuropharmacology and anti-inflammatory research.

Formula: C₁₆H₂₁NO₃

InChI: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)

InChI key: InChIKey=HJORMJIFDVBMOB-UHFFFAOYSA-N

SMILES: O=C1NCC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1

Synonyms:

• (.+-.)-Rolipram
• (R,S)-Rolipram
• 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
• Sb 95952
• Zk 62711
• BRN 1588548
• (4S)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
• (4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
• Rolipramum [Latin]
• Rolipramum
• Rolipram [USAN:INN]
• 4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone
• 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
• UNII-K676NL63N7
• 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-
• 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one

Rolipram

CAS: 61413-54-5

• Formula: C₁₆H₂₁NO₃
• Purity: >98.0%(HPLC)
• Color and Shape: White to Orange to Green powder to crystal
• Molecular weight: 275.35

(±)-Rolipram

CAS: 61413-54-5

• Formula: C₁₆H₂₁NO₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 275.3428

Rolipram

CAS: 61413-54-5

• Formula: C₁₆H₂₁NO₃
• Color and Shape: Off-White Solid
• Molecular weight: 275.35

Rolipram

CAS: 61413-54-5

• Formula: C₁₆H₂₁NO₃
• Purity: ≥ 97.0%
• Color and Shape: White to yellow powder
• Molecular weight: 275.34

Rolipram

CAS: 61413-54-5

• Purity: 99.26%
• Molecular weight: 275.34g/mol

(R,S)-Rolipram

CAS: 61413-54-5

• Purity: >99% (hplc) (Typical Value in Batch COA)
• Color and Shape: white crystalline solid
• Molecular weight: 275.34g/mol

Rolipram

CAS: 61413-54-5

Rolipram (SB 95952) is a phosphodiesterase 4 inhibitor with antidepressant properties.

• Formula: C₁₆H₂₁NO₃
• Purity: 99.22% - 99.26%
• Color and Shape: Solid
• Molecular weight: 275.34

Rolipram

CAS: 61413-54-5

M02441 - Rolipram

• Formula: C₁₆H₂₁NO₃
• Purity: >98%
• Color and Shape: Solid
• Molecular weight: 275.3479919433594

(±)-Rolipram

CAS: 61413-54-5

Applications (±)-Rolipram is a cAMP-specific phosphodiesterase 4 (PDE4) inhibitor. References Xin, W., et. al.: J. …

• Formula: C₁₆H₂₁NO₃
• Color and Shape: Neat
• Molecular weight: 275.34

Rolipram

CAS: 61413-54-5

Inhibitor of PDE4 enzyme; anti-inflammatory

• Formula: C₁₆H₂₁NO₃
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 275.34 g/mol