CAS 61413-54-5

Rolipram

Description:

Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor, primarily known for its potential therapeutic effects in treating conditions such as depression and inflammatory diseases. It is a white to off-white crystalline powder that is soluble in organic solvents like dimethyl sulfoxide (DMSO) and ethanol but has limited solubility in water. Rolipram's mechanism of action involves the inhibition of PDE4, which leads to increased levels of cyclic adenosine monophosphate (cAMP) in cells, thereby enhancing signaling pathways that can improve mood and reduce inflammation. The compound has a relatively low molecular weight and exhibits moderate lipophilicity, which influences its pharmacokinetic properties. Rolipram has been studied extensively in preclinical and clinical settings, although its use has been limited due to side effects associated with PDE4 inhibition. Overall, Rolipram represents an important compound in the field of medicinal chemistry, particularly in the context of neuropharmacology and anti-inflammatory research.

Formula: C₁₆H₂₁NO₃

InChI: InChI=1/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1

InChI key: InChIKey=HJORMJIFDVBMOB-UHFFFAOYSA-N

SMILES: O(C1=C(OC)C=CC(=C1)C2CNC(=O)C2)C3CCCC3

Synonyms:

• (.+-.)-Rolipram
• (R,S)-Rolipram
• 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
• Sb 95952
• Zk 62711
• BRN 1588548
• (4S)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
• (4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
• Rolipramum [Latin]
• Rolipramum
• Rolipram [USAN:INN]
• 4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone
• 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
• UNII-K676NL63N7
• 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-
• 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
• Roliprame
• ZK-62711, SB95952, ME-3167
• ROLIPRAM 98+%
• 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, ZK62711
• 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinon
• Rolipram, >=97%

Rolipram

CAS: 61413-54-5

Formula: C₁₆H₂₁NO₃

Purity: >98.0%(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 275.35

Ref: 3B-R0110

Rolipram

CAS: 61413-54-5

Rolipram

Formula: C₁₆H₂₁NO₃

Purity: ≥98%

Molecular weight: 275.34

Ref: 54-BUP15668

4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one

CAS: 61413-54-5

Formula: C₁₆H₂₁NO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 275.3428

Ref: IN-DA0035ZC

Rolipram

CAS: 61413-54-5

Formula: C₁₆H₂₁NO₃

Purity: ≥ 97.0%

Color and Shape: White to yellow powder

Molecular weight: 275.34

Ref: 7W-GP1881

Rolipram

CAS: 61413-54-5

Formula: C₁₆H₂₁NO₃

Color and Shape: Off-White Solid

Molecular weight: 275.35

Ref: 4Z-R-112001

Rolipram

CAS: 61413-54-5

Rolipram (SB 95952) is a phosphodiesterase 4 inhibitor with antidepressant properties.

Formula: C₁₆H₂₁NO₃

Purity: 98.89% - >99.99%

Color and Shape: Solid

Molecular weight: 275.34

Ref: TM-T6644

(R,S)-Rolipram

CAS: 61413-54-5

(R,S)-Rolipram

Formula: C₁₆H₂₁NO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 275.34284

Ref: 54-BIFK0003

(±)-Rolipram

Controlled Product

CAS: 61413-54-5

Applications (±)-Rolipram is a cAMP-specific phosphodiesterase 4 (PDE4) inhibitor.
References Xin, W., et. al.: J. Pharmacol. Exp. Ther., 349, 56 (2014);

Formula: C₁₆H₂₁NO₃

Color and Shape: Neat

Molecular weight: 275.34

Ref: TR-R640040

Rolipram

CAS: 61413-54-5

M02441 - Rolipram

Formula: C₁₆H₂₁NO₃

Purity: >98%

Color and Shape: Solid

Molecular weight: 275.3479919433594

Ref: 10-M02441

Rolipram

CAS: 61413-54-5

Inhibitor of PDE4 enzyme; anti-inflammatory

Formula: C₁₆H₂₁NO₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 275.34 g/mol

Ref: 3D-FR01270

Rolipram

CAS: 61413-54-5

Ref: BE-RMCR109000