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CAS 62-13-5

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Ethanone, 1-(3,4-dihydroxyphenyl)-2-(methylamino)-, hydrochloride (1:1)

Description:
Ethanone, 1-(3,4-dihydroxyphenyl)-2-(methylamino)-, hydrochloride (1:1), commonly known as methyldopa, is a pharmaceutical compound primarily used as an antihypertensive agent. It is characterized by its ability to lower blood pressure by acting as a centrally acting alpha-2 adrenergic agonist. The chemical structure features a dihydroxyphenyl group, which contributes to its biological activity, and a methylamino group that enhances its solubility and pharmacological properties. Methyldopa is typically administered in its hydrochloride salt form, which improves its stability and bioavailability. The compound is known for its relatively mild side effect profile compared to other antihypertensives, making it suitable for use in pregnant women. Its mechanism of action involves the conversion to alpha-methyl norepinephrine, which stimulates central alpha-adrenergic receptors, leading to reduced sympathetic outflow and decreased peripheral vascular resistance. Methyldopa is generally well-tolerated, but it can cause side effects such as sedation, dry mouth, and, in rare cases, liver dysfunction.
Formula:C9H11NO3·ClH
InChI:InChI=1S/C9H11NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,10-12H,5H2,1H3;1H
InChI key:InChIKey=CSRRBDMYOUQTCO-UHFFFAOYSA-N
SMILES:C(CNC)(=O)C1=CC(O)=C(O)C=C1.Cl
Synonyms:
  • 1-(3,4-Dihydroxyphenyl)-2-(Methylamino)Ethanone
  • 1-(3,4-Dihydroxyphenyl)-2-(Methylamino)Ethanone Hydrochloride (1:1)
  • 1-(3,4-Dihydroxyphenyl)-2-(methylamino)ethan-1-one hydrochloride
  • Acetophenone, 3′,4′-dihydroxy-2-(methylamino)-, hydrochloride
  • Adrenalone hydrochloride
  • Adrenone hydrochloride
  • Ethanone, 1-(3,4-dihydroxyphenyl)-2-(methylamino)-, hydrochloride
  • Ethanone, 1-(3,4-dihydroxyphenyl)-2-(methylamino)-, hydrochloride (1:1)
  • Kephrine hydrochloride
  • Styphnonasal
  • See more synonyms
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