CAS 62965-10-0

CBZ-L-tert-leucine

Description:

CBZ-L-tert-leucine, also known as carbobenzyloxy-L-tert-leucine, is a protected form of the amino acid leucine, commonly used in peptide synthesis. It features a carbobenzyloxy (CBZ) group, which serves as a protective group for the amino functionality, allowing for selective reactions without interference from the amine. The tert-butyl group in its structure enhances the steric hindrance, making it useful in various synthetic applications. This compound is typically a white to off-white solid and is soluble in organic solvents such as dichloromethane and dimethyl sulfoxide, but less soluble in water. Its stability under standard laboratory conditions makes it a valuable intermediate in organic synthesis, particularly in the preparation of peptides and other bioactive compounds. Additionally, CBZ-L-tert-leucine can be utilized in the development of pharmaceuticals and in research settings for studying protein interactions and functions. Proper handling and storage are essential, as with many chemical substances, to ensure safety and maintain its integrity for experimental use.

Formula: C₁₄H₁₉NO₄

InChI: InChI=1/C14H19NO4/c1-14(2,3)11(12(16)17)15-13(18)19-9-10-7-5-4-6-8-10/h4-8,11H,9H2,1-3H3,(H,15,18)(H,16,17)/t11-/m1/s1

InChI key: NSVNKQLSGGKNKB-LLVKDONJSA-N

SMILES: CC(C)(C)[C@@H](C(=O)O)N=C(O)OCc1ccccc1

Synonyms:

• L-valine, 3-methyl-N-[(phenylmethoxy)carbonyl]-
• N-[(Benzyloxy)carbonyl]-3-methyl-L-valine
• Z-Tle-OH

(S)-2-(((Benzyloxy)carbonyl)amino)-3,3-dimethylbutanoic acid

CAS: 62965-10-0

Formula: C₁₄H₁₉NO₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 265.3050

Ref: IN-DA003BOS

Cbz-Tle-OH

CAS: 62965-10-0

(S)-2-(((Benzyloxy)carbonyl)amino)-3,3-dimethylbutanoic acid

Formula: C₁₄H₁₉NO₄

Purity: 95%

Molecular weight: 265.31

Ref: IN-DG21891

CBZ-L-tert-Leucine

CAS: 62965-10-0

CBZ-L-tert-Leucine

Formula: C₁₄H₁₉NO₄

Purity: 99%

Molecular weight: 265.30496

Ref: 54-OR316031

Cbz-L-tert-Leucine

CAS: 62965-10-0

Formula: C₁₄H₁₉NO₄

Purity: 97%

Color and Shape: Liquid

Molecular weight: 265.309

Ref: 10-F079031

Cbz-L-tert-Leucine

Controlled Product

CAS: 62965-10-0

Applications Leucine derivative used in the preparation of various pharmaceutical agents such as TRPV4 antagonists, HIV-1 protease inhibitors and serine protease inhibitors.
References Perni, R.B. et al.: Bioorg. Med. Chem. Lett., 17, 3406 (2007); Ekegren, J.K. et al.: J. Med. Chem., 48, 8098 (2005);

Formula: C₁₄H₁₉NO₄

Color and Shape: Neat

Molecular weight: 265.3

Ref: TR-C227750