CAS 630124-46-8

Formula: C26H30F3N7O2

InChI: InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37)

InChI key: ODPGGGTTYSGTGO-UHFFFAOYSA-N

SMILES: CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)NC3=CC=C(C=C3)OC4=NC=NC(=C4)NC)C(F)(F)F

AST 487

CAS: 630124-46-8

AST 487

Formula: C₂₆H₃₀F₃N₇O₂

Purity: ≥98%

Molecular weight: 529.56

Ref: 54-BUP12779

N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea

CAS: 630124-46-8

Formula: C₂₆H₃₀F₃N₇O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 529.5573

Ref: IN-DA003AIY

AST-487

CAS: 630124-46-8

Ref: 7W-GW9454

AST 487

CAS: 630124-46-8

AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.

Formula: C₂₆H₃₀F₃N₇O₂

Purity: 98.17% - 99.56%

Color and Shape: Solid

Molecular weight: 529.56

Ref: TM-T4053

N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N’-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea

CAS: 630124-46-8

Purity: 99%

Color and Shape: Solid

Molecular weight: 529.5679932

Ref: 10-F862531

N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea

CAS: 630124-46-8

Formula: C₂₆H₃₀F₃N₇O₂

Color and Shape: Neat

Molecular weight: 529.56

Ref: TR-E926495

AST-487 (NVP-AST487)

CAS: 630124-46-8

AST-487 is a molecule that inhibits tyrosine kinase activity, which is associated with the proliferation and survival of cancer cells. It binds to the catalytic domain of the flt3 tyrosine kinase and blocks the activation of this enzyme. This drug has been shown to inhibit the formation of leukocyte antigen-expressing cells in vivo, which may be due to its ability to inhibit erythropoiesis. The structural analysis revealed that AST-487 binds to a region on Kinesin that is close to its ATP binding site. This binding prevents ATP from interacting with Kinesin, thereby inhibiting its function.

Formula: C₂₆H₃₀F₃N₇O₂

Purity: Min. 95%

Molecular weight: 529.56 g/mol

Ref: 3D-FAB12446