CAS 63527-52-6

Cefotaxime

Description:

Cefotaxime is a broad-spectrum cephalosporin antibiotic that is primarily used to treat a variety of bacterial infections. It is effective against both Gram-positive and Gram-negative bacteria, making it a versatile option in clinical settings. Cefotaxime works by inhibiting bacterial cell wall synthesis, which ultimately leads to cell lysis and death. The compound is typically administered via injection and is known for its relatively rapid onset of action. It is often used to treat infections such as pneumonia, urinary tract infections, and sepsis. Cefotaxime is generally well-tolerated, but like all antibiotics, it can cause side effects, including allergic reactions and gastrointestinal disturbances. Its pharmacokinetics involve good distribution in body tissues and fluids, with a half-life that allows for dosing every 6 to 12 hours, depending on the severity of the infection. Resistance to cefotaxime can occur, particularly in certain bacterial strains, necessitating careful consideration of its use in treatment regimens.

Formula: C₁₆H₁₇N₅O₇S₂

InChI: InChI=1S/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)/b20-9-/t10-,14-/m1/s1

InChI key: InChIKey=GPRBEKHLDVQUJE-QSWIMTSFSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C=3N=C(N)SC3)=O)C2=O)(SCC1COC(C)=O)[H]

Synonyms:

• (((2-amino- 4-thiazolyl)methoxyimino)acetyl)amino)-8-oxo-, (6r-(6alpha,7beta(z) 3-[(Acetyloxy)methyl]-7-[[(2-amino-4-thiazoly)(methoxyimino)acethyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid(sodium salt)
• (6R,7R)-3-[(Acetyl-oxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-3-[(acetyloxy)methyl]-7-{[(2-amino-1,3-thiazol-4-yl)(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-3-[(acetyloxy)methyl]-7-{[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-3-[(acetyloxy)methyl]-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6S,7S)-3-[(acetyloxy)methyl]-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, [6R-[6α,7α(Z)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, [6R-[6α,7β(Z)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)-
• Betaksim
• C-Tax
• Cefabol
• Cefotaxim
• Cefotaxima
• Cefotaxima acid
• Cefotaxime acid
• Ceftax
• Cephotaxime
• Claforan
• Hexime
• Omnatax
• Taxim
• Zeefotax
• sodium (6R,7R)-3-[(acetyloxy)methyl]-7-{[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Cefotaxime Sodium Salt

CAS: 63527-52-6, 64485-93-4

Formula: C₁₆H₁₆N₅NaO₇S₂

Purity: >96.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 477.44

Ref: 3B-C2224

CEFOTAXIME ACID CRS

CAS: 63527-52-6

CEFOTAXIME ACID CRS

Formula: C₁₆H₁₇N₅O₇S₂

Molecular weight: 455.4655

Ref: 41-Y0000420

Cefotaxime-13C-d3

CAS: 63527-52-6

Formula: C₁₅₁₃CH₁₄D₃N₅O₇S₂

Molecular weight: 459.47

Ref: 4Z-C-106013

Cefotaxime

CAS: 63527-52-6

Cefotaxime

Purity: ≥98%

Molecular weight: 455.47g/mol

Ref: 54-BUP14813

Cefotaxime

CAS: 63527-52-6

Cefotaxime is an inhibitor of penicillin binding protein.

Formula: C₁₆H₁₇N₅O₇S₂

Purity: 98.31% - 99.77%

Color and Shape: Solid

Molecular weight: 455.47

Ref: TM-T7733

Cefotaxime

CAS: 63527-52-6

Stability Hygroscopic
Applications Cefotaxime is an antibiotic with broad spectrum activity against Gram positive and Gram negative bacteria.

Formula: C₁₆H₁₇N₅O₇S₂

Color and Shape: White To Beige

Molecular weight: 455.47

Ref: TR-C242958

Cefotaxime

CAS: 63527-52-6

Cefotaxime is a third-generation cephalosporin antibiotic with action on bacterial cell wall synthesis and is used for treating severe bacterial infections like meningitis and sepsis.

Formula: C₁₆H₁₇N₅O₇S₂

Purity: (%) Min. 90%

Color and Shape: White Powder

Molecular weight: 455.47 g/mol

Ref: 3D-AC37153

Cefotaxime Sodium Impurity G

Controlled Product

CAS: 63527-52-6

Formula: C₂₂H₂₁N₈NaO₉S₃

Color and Shape: Neat

Molecular weight: 660.635

Ref: TR-C242955