CAS 63660-23-1

Guanosine, 2′-deoxy-N-(2-methyl-1-oxopropyl)-, 3′-benzoate

Description:

Guanosine, 2′-deoxy-N-(2-methyl-1-oxopropyl)-, 3′-benzoate, with the CAS number 63660-23-1, is a modified nucleoside derivative of guanosine. This compound features a deoxyribose sugar moiety, which is characteristic of deoxynucleosides, and is further modified by the presence of a benzoate group at the 3′ position and an N-(2-methyl-1-oxopropyl) substituent at the 2′ position. The presence of these functional groups suggests potential applications in medicinal chemistry, particularly in the development of antiviral or anticancer agents, as modifications to nucleosides can enhance their biological activity or selectivity. The compound is likely to exhibit properties typical of nucleosides, such as solubility in polar solvents and the ability to participate in hydrogen bonding. Additionally, the structural modifications may influence its stability, reactivity, and interaction with biological targets, making it a subject of interest for further research in biochemistry and pharmacology.

Formula: C₂₁H₂₃N₅O₆

InChI: InChI=1/C21H23N5O6/c1-11(2)18(28)24-21-23-17-16(19(29)25-21)22-10-26(17)15-8-13(14(9-27)31-15)32-20(30)12-6-4-3-5-7-12/h3-7,10-11,13-15,27H,8-9H2,1-2H3,(H2,23,24,25,28,29)

InChI key: InChIKey=LIOWMNSJEHKBBW-RRFJBIMHSA-N

SMILES: O=C1C2=C(N(C=N2)[C@H]3C[C@H](OC(=O)C4=CC=CC=C4)[C@@H](CO)O3)NC(NC(C(C)C)=O)=N1

Synonyms:

• 2'-Deoxy-N-(2-methyl-1-oxopropyl)guanosine 3'-benzoate
• 9-[2-deoxy-3-O-(phenylcarbonyl)pentofuranosyl]-2-[(2-methylpropanoyl)amino]-3,9-dihydro-6H-purin-6-one
• Guanosine, 2′-deoxy-N-(2-methyl-1-oxopropyl)-, 3′-benzoate

3''-O-Benzoyl-2''-deoxy-N2-isobutyrylguanosine

CAS: 63660-23-1

Formula: C₂₁H₂₃N₅O₆

Molecular weight: 441.44

Ref: 7W-GN9365

3'-O-Benzoyl-2'-deoxy-N2-isobutyrylguanosine

CAS: 63660-23-1

3'-O-Benzoyl-2'-deoxy-N2-isobutyrylguanosine is a new antiviral nucleoside, which has been synthesized by reacting benzoyl chloride with 2'-deoxy-N2-isobutyrylguanosine monophosphate. It is also a novel DNA and RNA phosphoramidite monomer that can be used for the synthesis of oligonucleotides and oligoribonucleotides. 3'-O-Benzoyl-2'-deoxy-N2-isobutyrylguanosine is an activator of HIV reverse transcriptase, which leads to inhibition of viral replication.

Formula: C₂₁H₂₃N₅O₆

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 441.44 g/mol

Ref: 3D-NB08023