CAS 637-07-0

Clofibrate

Description:

Clofibrate is a synthetic compound classified as a fibrate, primarily used as a lipid-lowering agent in the treatment of hyperlipidemia. Its chemical formula is C12H15ClO3, and it features a chlorinated aromatic ring structure, which contributes to its pharmacological properties. Clofibrate functions by activating peroxisome proliferator-activated receptors (PPARs), leading to increased fatty acid oxidation and reduced triglyceride levels in the bloodstream. It is typically administered orally and is known for its ability to lower cholesterol levels, particularly low-density lipoprotein (LDL) and triglycerides, while potentially raising high-density lipoprotein (HDL) levels. However, its use has declined due to concerns about side effects, including gastrointestinal disturbances and potential liver toxicity. Clofibrate is also associated with an increased risk of gallstones. As a result, it is often replaced by newer agents with improved safety profiles. Despite its reduced clinical use, it remains a significant compound in the study of lipid metabolism and cardiovascular health.

Formula: C₁₂H₁₅ClO₃

InChI: InChI=1/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3

InChI key: InChIKey=KNHUKKLJHYUCFP-UHFFFAOYSA-N

SMILES: O(C(C(OCC)=O)(C)C)C1=CC=C(Cl)C=C1

Synonyms:

• 2-(4-Chlorophenoxy)isobutyric acid ethyl ester
• 2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester
• Abitrate
• Amotril
• Anparton
• Apolan
• Arteriosan
• Artevil
• Ateculon
• Ateriosan
• Atheropront
• Atromid S
• Atromidin
• Ay 61123
• Azionyl
• Bioscleran
• Cartagyl
• Cinnarizine
• Claripex
• Claripex CPIB
• Clobren SF
• Clofibrat
• Clofibrato
• Clofinit
• Cpib
• Ecpib
• Epib
• Ethyl (p-chlorophenoxy) isobutyrate
• Ethyl 2-(4-Chlorophenoxy)-2-Methylpropanoate
• Ethyl 2-(4-Chlorophenoxy)-2-Methylpropionate
• Ethyl 2-(4-chlorophenoxy)isobutyrate
• Ethyl 2-(p-chlorophenoxy)-2-methylpropionate
• Ethyl 2-(p-chlorophenoxy)isobutyrate
• Ethyl clofibrate
• Ethyl p-chlorophenoxyisobutyrate
• Ethyl α-(4-chlorophenoxy)-α-methylpropionate
• Ethyl α-(4-chlorophenoxy)isobutyrate
• Ethyl α-(p-chlorophenoxy)-α-methylpropionate
• Ethyl α-(p-chlorophenoxy)isobutyrate
• Hyclorate
• Ici 28257
• Lipavil
• Lipavlon
• Lipomid
• Liprinal
• Miscleron
• Misclerone
• Neo-Atromid
• Normet
• Normolipol
• Nsc 79389
• Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, ethyl ester
• Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, ethyl ester
• Recolip
• Regelan
• Serotinex
• Sklerepmexe
• Sklero-Tablinene
• Sklerolip
• Skleromexe
• Ticlobran
• Xyduril
• p-Chlorophenoxyisobutyric acid ethyl ester
• CLOFIBRATE
• 19 more names available
• 2-(p-Chlorophenoxy)isobutyric acid ethyl ester
• 2-(4-CHLOROPHENOXY)-2-METHYLPROPIONIC ACID ETHYL ESTER
• CLOFIBRINIC ACID ETHYL ESTER
• Acetic acid, (p-chlorophenoxy)dimethyl-, ethyl ester
• alpha-(p-chlorophenoxy)isobutyricacid,ethylester
• CLOFIBRIC ACID ETHYL ESTER
• 2-(4-CHLOROPHENOXY)-2-METHYLPROPANOIC ACID ETHYL ESTER
• 2-(4-chlorophenoxy)-2-methyl-propanoicaciethylester
• 2-(4-chlorophenoxy)-2-methyl-propionicaciethylester
• 2-(p-chlorophenoxy)-2-methyl-propionicaciethylester
• alpha-(p-Chlorophenoxy)isobutyric acid, ethyl ester

Clofibrate, 95+%

CAS: 637-07-0

It is a lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL. It can increase the level of HDL as well. Clofibrate is a ligand agon

Formula: C₁₂H₁₅ClO₃

Purity: 95+%

Molecular weight: 242.7

Ref: 02-J60342

CLOFIBRATE CRS

CAS: 637-07-0

CLOFIBRATE CRS

Formula: C₁₂H₁₅ClO₃

Molecular weight: 242.6987

Ref: 41-C2300000

Clofibrate liquid

CAS: 637-07-0

Formula: C₁₂H₁₅ClO₃

Molecular weight: 242.70

Ref: 7W-GL9707

Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate

CAS: 637-07-0

Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate

Purity: 98%

Molecular weight: 242.6987g/mol

Ref: 54-OR26850

Clofibrate-d4

CAS: 637-07-0

Formula: C₁₀H₇ClO₃D₄

Molecular weight: 246.73

Ref: 4Z-C-242

Clofibrate

CAS: 637-07-0

Clofibrate

Purity: ≥98%

Molecular weight: 242.7g/mol

Ref: 54-BUP17771

Clofibrate

CAS: 637-07-0

Formula: C₁₂H₁₅ClO₃

Purity: >98.0%(GC)

Color and Shape: Colorless to Light yellow to Light orange clear liquid

Molecular weight: 242.70

Ref: 3B-C0941

Clofibrate

Controlled Product

CAS: 637-07-0

Formula: C₁₂H₁₅ClO₃

Color and Shape: Neat

Molecular weight: 242.70

Ref: 86-MM1934.00

Clofibrate

CAS: 637-07-0

Formula: C₁₂H₁₅ClO₃

Color and Shape: Neat

Molecular weight: 242.70

Ref: 04-C11682000

Clofibrate

CAS: 637-07-0

Clofibrate (Clofibrato) is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.

Formula: C₁₂H₁₅ClO₃

Purity: 98.77%

Color and Shape: Oil Liquid

Molecular weight: 242.70

Ref: TM-T1298

Clofibrate RS

CAS: 637-07-0

Color and Shape: Colorless - Slightly Yellow Liquid Clear Liquid

Ref: 2K-1049000021

Clofibrate

Controlled Product

CAS: 637-07-0

Applications Antilipemic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Metz, G., et al.: Arzneim.-Forsch., 27, 1173 (1977), Hassan, A.M., et al.: Anal. Profiles Drug Subs., 11, 197 (1982),

Formula: C₁₂H₁₅ClO₃

Color and Shape: Colourless

Molecular weight: 242.70

Ref: TR-C586910

Clofibrate

CAS: 637-07-0

Clofibrate is a lipid-lowering agent that is used for the treatment of hyperlipidemia. It is a non-selective inhibitor of fatty acid synthesis and has been shown to inhibit cancer cell growth in vitro. Clofibrate inhibits tumor cell proliferation and induces apoptosis, which may be due to its ability to inhibit protein synthesis in cancer cells. This drug also suppresses the growth of breast cancer cells by inhibiting their ability to proliferate.

Formula: C₁₂H₁₅ClO₃

Purity: Min. 95%

Color and Shape: Colorless Clear Liquid

Molecular weight: 242.7 g/mol

Ref: 3D-FC20499

Clofibrate

CAS: 637-07-0

M01536 - Clofibrate

Formula: C₁₂H₁₅ClO₃

Purity: 98%

Color and Shape: Liquid

Molecular weight: 242.7

Ref: 10-M01536

Clofibrate 100 µg/mL in Acetonitrile

CAS: 637-07-0

Formula: C₁₂H₁₅ClO₃

Color and Shape: Single Solution

Molecular weight: 242.70

Ref: 04-A11682000AL-100