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CAS 637-07-0

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Clofibrate

Description:
Clofibrate is a synthetic compound classified as a fibrate, primarily used as a lipid-lowering agent in the treatment of hyperlipidemia. Its chemical formula is C12H15ClO3, and it features a chlorinated aromatic ring structure, which contributes to its pharmacological properties. Clofibrate functions by activating peroxisome proliferator-activated receptors (PPARs), leading to increased fatty acid oxidation and reduced triglyceride levels in the bloodstream. It is typically administered orally and is known for its ability to lower cholesterol levels, particularly low-density lipoprotein (LDL) and triglycerides, while potentially raising high-density lipoprotein (HDL) levels. However, its use has declined due to concerns about side effects, including gastrointestinal disturbances and potential liver toxicity. Clofibrate is also associated with an increased risk of gallstones. As a result, it is often replaced by newer agents with improved safety profiles. Despite its reduced clinical use, it remains a significant compound in the study of lipid metabolism and cardiovascular health.
Formula:C12H15ClO3
InChI:InChI=1/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
InChI key:InChIKey=KNHUKKLJHYUCFP-UHFFFAOYSA-N
SMILES:O(C(C(OCC)=O)(C)C)C1=CC=C(Cl)C=C1
Synonyms:
  • 2-(4-Chlorophenoxy)isobutyric acid ethyl ester
  • 2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester
  • Abitrate
  • Amotril
  • Anparton
  • Apolan
  • Arteriosan
  • Artevil
  • Ateculon
  • Ateriosan
  • See more synonyms
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