CAS 637-07-0
:Clofibrate
Description:
Clofibrate is a synthetic compound classified as a fibrate, primarily used as a lipid-lowering agent in the treatment of hyperlipidemia. Its chemical formula is C12H15ClO3, and it features a chlorinated aromatic ring structure, which contributes to its pharmacological properties. Clofibrate functions by activating peroxisome proliferator-activated receptors (PPARs), leading to increased fatty acid oxidation and reduced triglyceride levels in the bloodstream. It is typically administered orally and is known for its ability to lower cholesterol levels, particularly low-density lipoprotein (LDL) and triglycerides, while potentially raising high-density lipoprotein (HDL) levels. However, its use has declined due to concerns about side effects, including gastrointestinal disturbances and potential liver toxicity. Clofibrate is also associated with an increased risk of gallstones. As a result, it is often replaced by newer agents with improved safety profiles. Despite its reduced clinical use, it remains a significant compound in the study of lipid metabolism and cardiovascular health.
Formula:C12H15ClO3
InChI:InChI=1/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
InChI key:InChIKey=KNHUKKLJHYUCFP-UHFFFAOYSA-N
SMILES:O(C(C(OCC)=O)(C)C)C1=CC=C(Cl)C=C1
Synonyms:- 2-(4-Chlorophenoxy)isobutyric acid ethyl ester
- 2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester
- Abitrate
- Amotril
- Anparton
- Apolan
- Arteriosan
- Artevil
- Ateculon
- Ateriosan
- Atheropront
- Atromid S
- Atromidin
- Ay 61123
- Azionyl
- Bioscleran
- Cartagyl
- Cinnarizine
- Claripex
- Claripex CPIB
- Clobren SF
- Clofibrat
- Clofibrato
- Clofinit
- Cpib
- Ecpib
- Epib
- Ethyl (p-chlorophenoxy) isobutyrate
- Ethyl 2-(4-Chlorophenoxy)-2-Methylpropanoate
- Ethyl 2-(4-Chlorophenoxy)-2-Methylpropionate
- Ethyl 2-(4-chlorophenoxy)isobutyrate
- Ethyl 2-(p-chlorophenoxy)-2-methylpropionate
- Ethyl 2-(p-chlorophenoxy)isobutyrate
- Ethyl clofibrate
- Ethyl p-chlorophenoxyisobutyrate
- Ethyl α-(4-chlorophenoxy)-α-methylpropionate
- Ethyl α-(4-chlorophenoxy)isobutyrate
- Ethyl α-(p-chlorophenoxy)-α-methylpropionate
- Ethyl α-(p-chlorophenoxy)isobutyrate
- Hyclorate
- Ici 28257
- Lipavil
- Lipavlon
- Lipomid
- Liprinal
- Miscleron
- Misclerone
- Neo-Atromid
- Normet
- Normolipol
- Nsc 79389
- Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, ethyl ester
- Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, ethyl ester
- Recolip
- Regelan
- Serotinex
- Sklerepmexe
- Sklero-Tablinene
- Sklerolip
- Skleromexe
- Ticlobran
- Xyduril
- p-Chlorophenoxyisobutyric acid ethyl ester
- CLOFIBRATE
- 19 more names available
- 2-(p-Chlorophenoxy)isobutyric acid ethyl ester
- 2-(4-CHLOROPHENOXY)-2-METHYLPROPIONIC ACID ETHYL ESTER
- CLOFIBRINIC ACID ETHYL ESTER
- Acetic acid, (p-chlorophenoxy)dimethyl-, ethyl ester
- alpha-(p-chlorophenoxy)isobutyricacid,ethylester
- CLOFIBRIC ACID ETHYL ESTER
- 2-(4-CHLOROPHENOXY)-2-METHYLPROPANOIC ACID ETHYL ESTER
- 2-(4-chlorophenoxy)-2-methyl-propanoicaciethylester
- 2-(4-chlorophenoxy)-2-methyl-propionicaciethylester
- 2-(p-chlorophenoxy)-2-methyl-propionicaciethylester
- alpha-(p-Chlorophenoxy)isobutyric acid, ethyl ester
- See more synonyms
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Clofibrate
CAS:Formula:C12H15ClO3Purity:>98.0%(GC)Color and Shape:Colorless to Light yellow to Light orange clear liquidMolecular weight:242.70Clofibrate, 95+%
CAS:It is a lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL. It can increase the level of HDL as well. Clofibrate is a ligand agonFormula:C12H15ClO3Purity:95+%Molecular weight:242.7Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
CAS:Ethyl 2-(4-chlorophenoxy)-2-methylpropanoateFormula:C12H15ClO3Purity:98%Color and Shape:LiquidMolecular weight:242.6987Ethyl Clofibrate-d4(4-chlorophenyl-d4)
CAS:Purity:98 atom % DColor and Shape:Colorless LiquidMolecular weight:246.73Clofibrate
CAS:Controlled ProductApplications Antilipemic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Metz, G., et al.: Arzneim.-Forsch., 27, 1173 (1977), Hassan, A.M., et al.: Anal. Profiles Drug Subs., 11, 197 (1982),Formula:C12H15ClO3Color and Shape:NeatMolecular weight:242.7Clofibrate
CAS:Clofibrate (Clofibrato) is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.Formula:C12H15ClO3Purity:98.77%Color and Shape:SolidMolecular weight:242.70Clofibrate
CAS:Ethyl 2-(4-chlorophenoxy)-2-methylpropanoateFormula:C12H15ClO3Purity:98%Molecular weight:242.7Clofibrate
CAS:M01536 - Clofibrate
Formula:C12H15ClO3Purity:98%Color and Shape:LiquidMolecular weight:242.7
