CAS 637-32-1

Proguanil hydrochloride

Description:

Proguanil hydrochloride is an antimalarial medication primarily used in the prevention and treatment of malaria. It is a synthetic compound that belongs to the biguanide class of drugs. The substance is characterized by its white to off-white crystalline powder form, which is soluble in water and exhibits a slightly bitter taste. Proguanil hydrochloride functions as a prodrug, being metabolized in the liver to its active form, cycloguanil, which inhibits dihydrofolate reductase, an enzyme crucial for the synthesis of folate in the malaria parasite. This action disrupts the parasite's ability to reproduce and survive within the host. The compound has a relatively low toxicity profile, making it suitable for use in various populations, including children and pregnant women. Additionally, it is often used in combination with other antimalarial agents to enhance efficacy and reduce the risk of resistance development. As with any medication, it is essential to consider potential side effects and contraindications when prescribing or using proguanil hydrochloride.

Formula: C₁₁H₁₇Cl₂N₅

InChI: InChI=1/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H

InChI key: InChIKey=SARMGXPVOFNNNG-UHFFFAOYSA-N

SMILES: N(C(NC(NC(C)C)=N)=N)C1=CC=C(Cl)C=C1.Cl

Synonyms:

• 1-(p-Chlorophenyl)-5-isopropylbiguanide hydrochloride
• 1-[N′-(4-Chlorophenyl)carbamimidamido]-N-(propan-2-yl)methanimidamide hydrochloride
• 1-{(1E)-amino[(4-chlorophenyl)amino]methylidene}-2-(1-methylethyl)guanidine hydrochloride
• 3359 Rp
• Biguanide, 1-(p-chlorophenyl)-5-isopropyl-, monohydrochloride
• Chloroguanide hydrochloride
• Chloroquanil
• Diguanyl
• Drinupal
• Drinupal hydrochloride
• Guanatol
• Guanatol hydrochloride
• Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, Hydrochloride (1:1)
• Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N′-(1-methylethyl)-, monohydrochloride
• M 4888
• Paludrine
• Paludrine hydrochloride
• Palusil
• Palusil hydrochloride
• Proguanil HCL
• Rp 3359
• Sn 12,837
• Tirian
• Tirian hydrochloride
• chlorguanidehydrochloride
• Proguanil Hydrochloride (200 mg)
• drinupalhydrochloride
• Paludrin
• m4888
• PROGUANIL HYDROCHLORIDE
• n-4-chlorophenyl-n(sup5)-isopropyldiguanidehydrochloride
• Chlorguanid
• N1-(4-Chlorophenyl)-N5-isopropylbiguanide
• 1-(p-chlorophenyl)-5-isopropyl-biguanidmonohydrochloride
• 3359rp
• sn12,837
• guanatolhydrochloride
• Chlorguanide Hydrochloride3
• palusilhydrochloride
• chloroguanidinehydrochloride
• N-(4-Chlorophenyl)-N'-(1-methylethyl)-imidodicarbonimidic Diamide Hydrochloride
• PROGUANIL HYDROCHLORIDE###N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE
• paludrinehydrochloride
• ChlorguanideHCl
• chloroguanidehydrochloride

Proguanil Hydrochloride

CAS: 637-32-1

Color and Shape: Neat

Ref: 61-FOR0840.00

PROGUANIL HYDROCHLORIDE CRS

CAS: 637-32-1

PROGUANIL HYDROCHLORIDE CRS

Formula: C₁₁H₁₇Cl₂N₅

Molecular weight: 290.1922

Ref: 41-Y0001901

Proguanil hydrochloride

CAS: 637-32-1

Proguanil hydrochloride

Formula: C₁₁H₁₆ClN₅HCl

Purity: 99.6%

Color and Shape: White Crystalline Powder

Molecular weight: 289.0861

Ref: 47-297

PROGUANIL FOR SYSTEM SUITABILITY CRS

CAS: 637-32-1

PROGUANIL FOR SYSTEM SUITABILITY CRS

Formula: C₁₁H₁₇Cl₂N₅

Color and Shape: White. Crystalline Powder.

Molecular weight: 290.1922

Ref: 41-Y0001885

Proguanil Hydrochloride

CAS: 637-32-1

Aromatic imines and their derivatives, salts thereof

Formula: C₁₁H₁₆ClN₅·HCl

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 253.10942

Ref: 45-1568040

Proguanil hydrochloride

CAS: 637-32-1

Proguanil hydrochloride

Purity: ≥98%

Molecular weight: 290.19g/mol

Ref: 54-BUP14518

Proguanil Hydrochloride

CAS: 637-32-1

Proguanil Hydrochloride

Purity: 97%

Molecular weight: 290.19g/mol

Ref: 54-OR1023733

Proguanil Hydrochloride

Controlled Product

CAS: 637-32-1

Formula: C₁₁H₁₆ClN₅·ClH

Color and Shape: Neat

Molecular weight: 290.19

Ref: 86-MM0840.00

Proguanil hydrochloride

CAS: 637-32-1

Formula: C₁₁H₁₆ClN₅·HCl

Molecular weight: 290.19

Ref: 7W-GL3057

Proguanil hydrochloride

CAS: 637-32-1

Proguanil hydrochloride, a biguanide, metabolizes into cycloguanil, an anti-malaria agent that inhibits plasmodium's DNA and protein synthesis.

Formula: C₁₁H₁₇Cl₂N₅

Purity: 98.34% - 98.39%

Color and Shape: Solid

Molecular weight: 290.19

Ref: TM-T4382

Chlorguanide Hydrochloride

Controlled Product

CAS: 637-32-1

Formula: C₁₁H₁₆ClN₅·ClH

Color and Shape: White

Molecular weight: 290.19

Ref: TR-C329500

Proguanil hydrochloride

CAS: 637-32-1

Proguanil hydrochloride is a drug used to treat malaria. It is a prodrug that is activated in the liver by hepatic esterases and converted to chloroguanide. Proguanil hydrochloride binds to DNA-dependent RNA polymerase, which inhibits transcription and replication of bacterial DNA. This drug also has effects on cardiac cells and can worsen congestive heart disease. Proguanil hydrochloride has been shown to interact with other drugs, such as acetaminophen, phenytoin, and warfarin, which can result in serious side effects. Proguanil hydrochloride is not active against some types of bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex.

Formula: C₁₁H₁₇Cl₂N₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 290.19 g/mol

Ref: 3D-FC19929

Chlorguanide-d6 Hydrochloride

Controlled Product

CAS: 637-32-1

Applications Chlorguanide-d6 Hydrochloride, is a labeled analogue of Chlorguanide (C329500), used as Antimalarial.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Schmidt., et al.: J. Pharmacol. Exp. Ther., 90, 233 (1947), Cortese, J., et al.: J. Infect. Dis., 186, 999 (2002), Lim, P., et al.: Antimicrob. Agents Chemother., 47, 87 (2003), Sidhu, A., et al.: Mol. Microbiol., 57, 913 (2005),

Formula: C₁₁H₁₁D₆Cl₂N₅

Color and Shape: Neat

Molecular weight: 296.23

Ref: TR-C329503