CAS 63775-96-2

Cyclosporin D

Description:

Cyclosporin D, with the CAS number 63775-96-2, is a cyclic polypeptide that belongs to the class of immunosuppressive agents. It is derived from the fungus Tolypocladium inflatum and is structurally related to cyclosporin A, differing primarily in its amino acid composition. Cyclosporin D exhibits potent immunosuppressive properties, making it valuable in preventing organ transplant rejection and treating autoimmune diseases. The compound functions by inhibiting T-cell activation and proliferation, primarily through the inhibition of calcineurin, which is crucial for the activation of T-cell transcription factors. In terms of solubility, cyclosporin D is lipophilic, which affects its bioavailability and distribution in biological systems. Its pharmacokinetics can be influenced by various factors, including formulation and patient-specific variables. While cyclosporin D has therapeutic applications, it also has potential side effects, including nephrotoxicity and increased susceptibility to infections, necessitating careful monitoring during treatment. Overall, cyclosporin D represents an important compound in the field of immunology and transplant medicine.

Formula: C₆₃H₁₁₁N₁₁O₁₂

InChI: InChI=1/C63H113N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)51(40(14)15)63(86)74(52)25/h26-27,34-47,49-53,76H,28-33H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)(H,67,80)/b27-26+/t41-,42+,43-,44+,45+,46-,47+,49+,50+,51+,52?,53-/m1/s1

Synonyms:

• Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
• (3S,6S,9R,12R,15S,18S,21S,24S,30S)-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21,30-tris(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• 7-L-Valinecyclosporin A
• Cyclosporine IMpurity-D
• CYCLOSPORIN D
• Cyclosporin D, >=95%
• (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Val-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
• Cyclosporin D solution
• Cyclosporin D, froM MicroMonospora
• 1-(3-Chlorophenyl)piperazine-D8 hydrochloride solution
• (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Val-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
• 7-L-valinecyclosporine A

Cyclosporin D

CAS: 63775-96-2

Lactams, nesoi

Formula: C₆₃H₁₁₃N₁₁O₁₂

Color and Shape: White Off-White Solid

Molecular weight: 1215.85702

Ref: 45-1A04270

Cyclosporin D

CAS: 63775-96-2

Formula: C₆₃H₁₁₃N₁₁O₁₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 1216.6378

Ref: IN-DA00395F

Cyclosporin D

CAS: 63775-96-2

Cyclosporin D, a cyclosporin A metabolite, suppresses the immune system by blocking T cell calcineurin phosphatase via cyclophilin D binding.

Formula: C₆₃H₁₁₃N₁₁O₁₂

Purity: 98%

Color and Shape: Less To Off-White Crystalline Solid Colorless To Off-White Crystalline Solid

Molecular weight: 1216.662

Ref: TM-TP1665

Ciclosporin EP Impurity G (Cyclosporin D)

CAS: 63775-96-2

Formula: C₆₃H₁₁₃N₁₁O₁₂

Molecular weight: 1216.66

Ref: 4Z-PC-542

IRBP acetate(211426-18-5 free base)

CAS: 63775-96-2

IRBP acetate(211426-18-5 free base)

Purity: ≥95%

Molecular weight: 2269.55g/mol

Ref: 54-BUP20460

Cyclosporin D

CAS: 63775-96-2

Formula: C₆₃H₁₁₃N₁₁O₁₂

Purity: 95%~99%

Molecular weight: 1216.66

Ref: BP-BP0440

Cyclosporin D

CAS: 63775-96-2

Formula: C₆₃H₁₁₃N₁₁O₁₂

Purity: ≥ 95%

Color and Shape: White to off-white powder

Molecular weight: 1216.64

Ref: 7W-GP9440

Cyclosporin EP Impurity G

CAS: 63775-96-2

Formula: C₆₃H₁₁₁N₁₁O₁₂

Molecular weight: 1214.6

Ref: ST-EA-CP-C162006

Cyclosporin D

Controlled Product

CAS: 63775-96-2

Applications A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Formula: C₆₃H₁₁₃N₁₁O₁₂

Color and Shape: Off-White

Molecular weight: 1216.64

Ref: TR-C988910

Cyclosporin D

CAS: 63775-96-2

Inhibits phorbol ester TPA/PMA; immunosuppressant

Formula: C₆₃H₁₁₃N₁₁O₁₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,216.64 g/mol

Ref: 3D-FC20756

Cyclosporin D-d4

Controlled Product

CAS: 63775-96-2

Formula: C₆₃H₁₀₉D₄N₁₁O₁₂

Color and Shape: Neat

Molecular weight: 1220.69

Ref: TR-C988912