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CAS 63775-96-2

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Cyclosporin D

Description:
Cyclosporin D, with the CAS number 63775-96-2, is a cyclic polypeptide that belongs to the class of immunosuppressive agents. It is derived from the fungus Tolypocladium inflatum and is structurally related to cyclosporin A, differing primarily in its amino acid composition. Cyclosporin D exhibits potent immunosuppressive properties, making it valuable in preventing organ transplant rejection and treating autoimmune diseases. The compound functions by inhibiting T-cell activation and proliferation, primarily through the inhibition of calcineurin, which is crucial for the activation of T-cell transcription factors. In terms of solubility, cyclosporin D is lipophilic, which affects its bioavailability and distribution in biological systems. Its pharmacokinetics can be influenced by various factors, including formulation and patient-specific variables. While cyclosporin D has therapeutic applications, it also has potential side effects, including nephrotoxicity and increased susceptibility to infections, necessitating careful monitoring during treatment. Overall, cyclosporin D represents an important compound in the field of immunology and transplant medicine.
Formula:C63H111N11O12
InChI:InChI=1/C63H113N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)51(40(14)15)63(86)74(52)25/h26-27,34-47,49-53,76H,28-33H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)(H,67,80)/b27-26+/t41-,42+,43-,44+,45+,46-,47+,49+,50+,51+,52?,53-/m1/s1
InChI key:ZNVBEWJRWHNZMK-SYOLRUPNSA-N
SMILES:C/C=C/C[C@@H](C)[C@H]([C@H]1C(=O)N[C@H](C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)C)O
Synonyms:
  • Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
  • (3S,6S,9R,12R,15S,18S,21S,24S,30S)-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21,30-tris(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
  • 7-L-Valinecyclosporin A
  • Cyclosporine IMpurity-D
  • CYCLOSPORIN D
  • Cyclosporin D, >=95%
  • (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Val-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
  • Cyclosporin D solution
  • Cyclosporin D, froM MicroMonospora
  • 1-(3-Chlorophenyl)piperazine-D8 hydrochloride solution
  • See more synonyms
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