CAS 63968-64-9

Artemisinin

Description:

Artemisinin is a sesquiterpene lactone with the chemical formula C15H22O5, primarily derived from the sweet wormwood plant, Artemisia annua. It is renowned for its potent antimalarial properties and is a key component in artemisinin-based combination therapies (ACTs) used to treat malaria. The compound features a unique endoperoxide bridge, which is crucial for its biological activity. Artemisinin exhibits moderate solubility in organic solvents like ethanol and chloroform but has limited solubility in water. Its mechanism of action involves the generation of reactive oxygen species upon activation by heme, leading to the destruction of malaria parasites. Artemisinin is generally well-tolerated, though it can cause side effects such as nausea and dizziness in some patients. Due to its natural origin and efficacy, research continues into optimizing its derivatives and enhancing its pharmacological properties. Additionally, ongoing studies are exploring its potential applications beyond malaria, including its effects on various cancers and other diseases.

Formula: C₁₅H₂₂O₅

InChI: InChI=1/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14+,15-/m1/s1

InChI key: InChIKey=BLUAFEHZUWYNDE-NNWCWBAJSA-N

SMILES: C[C@@H]1[C@]2([C@]34[C@@](O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])(OC1=O)[H])[H]

Synonyms:

• (+)-Arteannuin
• (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
• (3S,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• (5aS,6R,8aS,9R,12S)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,12S,12aR)-
• 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, [3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]-
• 3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• ARTIVeda
• Artemef
• Artemisine
• Artemisinine
• Hc 101A
• Huanghuahaosu
• NSC 369397
• PulmoHeal
• Qing Hau Sau
• Qing Hau Su
• Qinghaosu
• Qinghosu
• [3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-one
• Artemisinin
• Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one
• ARTEANUIN
• (3-alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12ar*)-(+)-methyl
• Artemisinin Qinghaosu/ [3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-one
• ARTEMISININ (QINGHAOSU)
• SWEET WORMWOOD
• artemisiaannual.,extract
• ARTEMETHER
• 3,12-epoxy-12h-pyranol(4,3-j)-1,2-benzodioxepin-10(3h)-one,octahydro-3,6,9-tri
• ArteMisinin, 98%, froM ArteMisia annua L.
• qinghausau
• ARTEMISININ 99%
• 3,13-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)one,(ctahydro-3,6,9-trimethyl-,[3R-(3α,5αβ,6β,8αβ,9α,12β,12αR*)]-
• Arteannuin99%
• (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epox12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
• Artemisinine,98%
• QHS
• Astemisinin
• Arteannuin, Qinghaosu
• ARTEMISIA P E
• QINGHAOSA
• octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano(4,3-j)-1,2-benzodioxepin-10(
• ALPHA BETA ARTEMISININ
• Quinghaosu
• qinghausu
• ArteMisinin, froM ArteMisia annua
• 3,12-Epoxy-12H-pyranol(4,3-j)-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (3-alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12aR*)-(+)
• (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3 ,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
• ARTEMISIA ANNUA
• Artemisine，Artemisinin，Arteannuin
• Artemisia annual L Ext.

Artemisinin

CAS: 63968-64-9

Formula: C₁₅H₂₂O₅

Purity: >97.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 282.34

Ref: 3B-A2118

Artemisinin, 98%

CAS: 63968-64-9

Artemisinin inhibits angiogenesis by down-regulating HIF-1 and VEGF expression in mouse embryonic stem cells. Artemisinin crosses the blood-brain barrier and is an inhibitor of human NOS2 (iNOS). This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio.

Formula: C₁₅H₂₂O₅

Purity: 98%

Color and Shape: Crystals or crystalline powder, White

Molecular weight: 282.34

Ref: 02-J65406

ARTEMISININ RS

CAS: 63968-64-9

ARTEMISININ RS

Formula: C₁₅H₂₂O₅

Color and Shape: Powder

Molecular weight: 282.3322

Ref: 41-ICRS43857

Artemisinin

CAS: 63968-64-9

Heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₁₅H₂₂O₅

Color and Shape: White Off-White Solid

Molecular weight: 282.14672

Ref: 45-1042747

(1R,4S,5R,8S,9R,12S,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecan-10-one

CAS: 63968-64-9

Formula: C₁₅H₂₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 282.3322

Ref: IN-DA00IBB0

Artemisinin

CAS: 63968-64-9

Artemisinin (Qinghaosu) is a natural sesquiterpene lactone. Artemisinin has anti-malarial, neuroprotective and anti-tumor effects. Cost-effective and quality-assured.

Formula: C₁₅H₂₂O₅

Purity: 99.77% - 99.87%

Color and Shape: Crystalline Solid

Molecular weight: 282.33

Ref: TM-T0392

Artemisinin

CAS: 63968-64-9

Formula: C₁₅H₂₂O₅

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 282.33

Ref: 7W-GP0718

Artemisinin

CAS: 63968-64-9

Artemisinin

Purity: ≥95%

Molecular weight: 282.33g/mol

Ref: 54-BUP16845

Artemisinin

CAS: 63968-64-9

Formula: C₁₅H₂₂O₅

Molecular weight: 282.34

Ref: 4Z-A-309

Artemisinin

CAS: 63968-64-9

Color and Shape: Neat

Ref: 86-MM0803.00

Artemisinin

CAS: 63968-64-9

Formula: C₁₅H₂₂O₅

Purity: 95%~99%

Molecular weight: 282.336

Ref: BP-BP0197

Artemisinin

CAS: 63968-64-9

Artemisinin

Formula: C₁₅H₂₂O₅

Purity: 97%

Color and Shape: white crystalline needles

Molecular weight: 282.33g/mol

Ref: 54-BIA4320

Artemisinin

CAS: 63968-64-9

Lactone

Formula: C₁₅H₂₂O₅

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 282.34

Ref: 5G-89484

Artemisinin

CAS: 63968-64-9

Artemisinin is a sesquiterpene lactone, which is derived from the plant Artemisia annua, commonly known as sweet wormwood. This compound is isolated through a series of extraction and purification processes from the plant's leaves and flowers. Artemisinin exerts its pharmacological effect through a novel mode of action that involves endoperoxide bridges, which interact with intracellular iron to generate free radicals. These reactive species subsequently damage vital biomolecules within Plasmodium parasites, effectively inhibiting their ability to thrive and reproduce.

Formula: C₁₅H₂₂O₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 282.33 g/mol

Ref: 3D-FA09640

Artemisinin-d4

Controlled Product

CAS: 63968-64-9

Formula: C₁₅D₄H₁₈O₅

Color and Shape: Neat

Molecular weight: 286.357

Ref: TR-A777503

Artemisinin-13C-D3

Controlled Product

CAS: 63968-64-9

Formula: CC₁₄D₃H₁₉O₅

Color and Shape: Neat

Molecular weight: 286.343

Ref: TR-A777504

Artesunate IP Impurity B

CAS: 63968-64-9

Formula: C₁₅H₂₂O₅

Molecular weight: 282.34

Ref: ST-EA-CP-A93012

Artemisinin

CAS: 63968-64-9

Formula: C₁₅H₂₂O₅

Color and Shape: White to Off-White Solid

Molecular weight: 282.33

Ref: TR-A777500